Detailed view for EHI_100320

Basic information

TDR Targets ID: 804515
Entamoeba histolytica, multidrug resistance protein, putative

Source Database / ID:  AmoebaDB  

pI: 7.2496 | Length (AA): 1600 | MW (Da): 181513 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 16

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter
PF00664   ABC transporter transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0042626   ATPase activity, coupled to transmembrane movement of substances  
GO:0016021   integral to membrane  
GO:0005524   ATP binding  
GO:0016887   ATPase activity  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
348 1557 5ko2 (A) 28 1268 17.00 0 1 0.89225 0.44
719 943 2cbz (A) 644 872 47.00 0 1 0.796025 -1.06
1316 1587 3gd7 (A) 1202 1474 31.00 0 1 0.621 -0.74
1319 1536 5eum (A) 342 561 37.00 0 1 0.70365 -1.38
1324 1600 4fwi (B) 5 295 17.00 0 1 0.335025 -0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite. Hon CC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_126561)

Species Accession Gene Product
Arabidopsis thaliana AT3G13100   ABC transporter C family member 7
Arabidopsis thaliana AT2G47800   ABC transporter C family member 4
Arabidopsis thaliana AT3G62700   ABC transporter C family member 14
Arabidopsis thaliana AT1G30420   ABC transporter C family member 11
Arabidopsis thaliana AT1G30410   multidrug resistance-associated protein 13
Arabidopsis thaliana AT3G59140   multidrug resistance-associated protein 14
Arabidopsis thaliana AT1G30400   glutathione S-conjugate transporting ATPase
Arabidopsis thaliana AT3G60970   putative ABC transporter C-15
Arabidopsis thaliana AT2G34660   ABC transporter C family member 2
Arabidopsis thaliana AT3G21250   multidrug resistance-associated protein 6
Arabidopsis thaliana AT3G13080   ABC transporter C family member 3
Arabidopsis thaliana AT2G07680   multidrug resistance-associated protein 11
Arabidopsis thaliana AT1G04120   inositol hexakisphosphate transporter
Arabidopsis thaliana AT3G60160   multidrug resistance-associated protein 9
Arabidopsis thaliana AT3G13090   multidrug resistance-associated protein 8
Babesia bovis BBOV_III005820   ABC transporter family protein
Babesia bovis BBOV_III006450   ABC transporter family protein
Babesia bovis BBOV_III005570   ABC transporter family protein
Babesia bovis BBOV_I003180   ABC transporter, ATP-binding protein domain containing protein
Brugia malayi Bm1_43555   ABC transporter transmembrane region family protein
Brugia malayi Bm1_06395   multidrug resistance related protein 1
Candida albicans CaO19.6383   one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W)
Candida albicans CaO19.6382   one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W)
Candida albicans CaO19_6478   hypothetical protein
Candida albicans CaO19.12566   vacuolar ABC transporter similar to multiple drug resistance-associated protein
Candida albicans CaO19.13740   one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W)
Candida albicans CaO19.5100   vacuolar ABC transporter similar to multiple drug resistance-associated protein
Candida albicans CaO19.13739   one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W)
Candida albicans CaO19.6478   similar to vacuolar membrane ATP-dependant transporter, metal resistance protein
Candida albicans CaO19.13832   similar to vacuolar membrane ATP-dependant transporter, metal resistance protein
Caenorhabditis elegans CELE_F57C12.4   Protein MRP-2
Caenorhabditis elegans CELE_F21G4.2   Protein MRP-4
Caenorhabditis elegans CELE_F20B6.3   Protein MRP-6
Caenorhabditis elegans CELE_Y43F8C.12   Protein MRP-7
Caenorhabditis elegans CELE_Y75B8A.26   Protein MRP-8
Caenorhabditis elegans CELE_E03G2.2   Protein MRP-3
Caenorhabditis elegans CELE_F57C12.5   Protein MRP-1, isoform D
Caenorhabditis elegans CELE_F14F4.3   Protein MRP-5, isoform A
Cryptosporidium hominis Chro.70499   SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP))
Cryptosporidium parvum cgd7_4520   ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene
Cryptosporidium parvum cgd1_700   ATP-binding cassette protein
Dictyostelium discoideum DDB_G0280055   ABC transporter C family protein
Dictyostelium discoideum DDB_G0286559   ABC transporter C family protein
Dictyostelium discoideum DDB_G0291243   ABC transporter C family protein
Dictyostelium discoideum DDB_G0280541   ABC transporter C family protein
Dictyostelium discoideum DDB_G0287691   ABC transporter C family protein
Dictyostelium discoideum DDB_G0280973   ABC transporter C family protein
Dictyostelium discoideum DDB_G0285165   ABC transporter C family protein
Dictyostelium discoideum DDB_G0287593   ABC transporter C family protein
Dictyostelium discoideum DDB_G0280977   ABC transporter C family protein
Dictyostelium discoideum DDB_G0284867   ABC transporter C family protein
Dictyostelium discoideum DDB_G0280539   ABC transporter C family protein
Dictyostelium discoideum DDB_G0280459   ABC transporter C family protein
Dictyostelium discoideum DDB_G0287589   ABC transporter C family protein
Drosophila melanogaster Dmel_CG10505   CG10505 gene product from transcript CG10505-RA
Drosophila melanogaster Dmel_CG5789   CG5789 gene product from transcript CG5789-RA
Drosophila melanogaster Dmel_CG11898   CG11898 gene product from transcript CG11898-RB
Drosophila melanogaster Dmel_CG31793   CG31793 gene product from transcript CG31793-RC
Drosophila melanogaster Dmel_CG7806   CG7806 gene product from transcript CG7806-RA
Drosophila melanogaster Dmel_CG31792   CG31792 gene product from transcript CG31792-RC
Drosophila melanogaster Dmel_CG14709   Multidrug resistance protein 4 ortholog
Drosophila melanogaster Dmel_CG6214   Multidrug-Resistance like Protein 1
Drosophila melanogaster Dmel_CG9270   CG9270 gene product from transcript CG9270-RC
Drosophila melanogaster Dmel_CG8799   lethal (2) 03659
Drosophila melanogaster Dmel_CG4562   CG4562 gene product from transcript CG4562-RC
Drosophila melanogaster Dmel_CG7627   CG7627 gene product from transcript CG7627-RB
Drosophila melanogaster Dmel_CG11897   CG11897 gene product from transcript CG11897-RB
Echinococcus granulosus EgrG_000248800   multidrug resistance associated protein 4
Echinococcus granulosus EgrG_000592100   multidrug resistance associated protein 1
Echinococcus granulosus EgrG_000828700   multidrug resistance associated protein 7
Entamoeba histolytica EHI_134470   ATP-binding cassette protein, putative
Entamoeba histolytica EHI_124840   ABC transporter, putative
Entamoeba histolytica EHI_060870   hypothetical protein
Entamoeba histolytica EHI_095820   ATP-binding cassette protein, putative
Entamoeba histolytica EHI_100320   multidrug resistance protein, putative
Entamoeba histolytica EHI_178050   ATP-binding cassette protein, putative
Entamoeba histolytica EHI_178580   ATP-binding cassette protein, putative
Echinococcus multilocularis EmuJ_000248800   multidrug resistance associated protein 4
Echinococcus multilocularis EmuJ_000828700   multidrug resistance associated protein 7
Echinococcus multilocularis EmuJ_000592100   multidrug resistance associated protein 1
Giardia lamblia GL50803_115052   Multidrug resistance-associated protein 1
Giardia lamblia GL50803_28379   Multidrug resistance-associated protein 1
Giardia lamblia GL50803_17132   MRP-like ABC transporter
Giardia lamblia GL50803_221689   ABC transporter, putative
Giardia lamblia GL50803_41118   Multidrug resistance-associated protein 1
Homo sapiens 101930322   multidrug resistance-associated protein 6-like
Homo sapiens ENSG00000140798   ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Homo sapiens ENSG00000124574   ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Homo sapiens ENSG00000006071   ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Homo sapiens ENSG00000125257   ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Homo sapiens ENSG00000023839   ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Homo sapiens ENSG00000114770   ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Homo sapiens ENSG00000108846   ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Homo sapiens ENSG00000069431   ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Homo sapiens ENSG00000121270   ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Homo sapiens ENSG00000103222   ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Leishmania braziliensis LbrM.23.0230   multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative
Leishmania braziliensis LbrM.31.1510   p-glycoprotein e, putative
Leishmania braziliensis LbrM.23.0280   ABC-thiol transporter
Leishmania braziliensis LbrM.31.1500   p-glycoprotein e
Leishmania braziliensis LbrM.23.0740   multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative
Leishmania donovani LdBPK_311460.1   pentamidine resistance protein 1
Leishmania infantum LinJ.23.0290   ABC-thiol transporter
Leishmania infantum LinJ.31.1460   pentamidine resistance protein 1
Leishmania infantum LinJ.31.1290   p-glycoprotein e
Leishmania infantum LinJ.23.0230   ATP-binding cassette protein subfamily C, member 1, putative
Leishmania infantum LinJ.31.1300   ATP-binding cassette protein subfamily C, member 5, putative
Leishmania infantum LinJ.31.1310   ATP-binding cassette protein subfamily C, member 6, putative
Leishmania infantum LinJ.23.0240   ATP-binding cassette protein subfamily C, member 2, putative
Leishmania major LmjF.31.1430   pentamidine resistance protein 1
Leishmania major LmjF.23.0220   ATP-binding cassette protein subfamily C, member 2, putative
Leishmania major LmjF.23.0210   ATP-binding cassette protein subfamily C, member 1, putative
Leishmania major LmjF.23.0250   ABC-thiol transporter
Leishmania major LmjF.31.1280   ATP-binding cassette protein subfamily C, member 5, putative
Leishmania major LmjF.31.1270   p-glycoprotein e
Leishmania major LmjF.31.1290   ATP-binding cassette protein subfamily C, member 6, putative
Leishmania mexicana LmxM.30.1430   p-glycoprotein-like protein
Leishmania mexicana LmxM.30.1270   p-glycoprotein e
Leishmania mexicana LmxM.30.1280   p-glycoprotein e, putative
Leishmania mexicana LmxM.23.0220   multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative
Leishmania mexicana LmxM.23.0250   ABC-thiol transporter
Leishmania mexicana LmxM.23.0210   ATP-binding cassette protein subfamily C, member 1, putative
Leishmania mexicana LmxM.30.1290   multidrug resistance protein, copy 1-like protein
Loa Loa (eye worm) LOAG_09103   hypothetical protein
Loa Loa (eye worm) LOAG_00362   hypothetical protein
Loa Loa (eye worm) LOAG_02727   hypothetical protein
Loa Loa (eye worm) LOAG_05713   multidrug resistance-associated protein
Loa Loa (eye worm) LOAG_09104   ABC transporter transmembrane region family protein
Mus musculus ENSMUSG00000036872   ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Mus musculus ENSMUSG00000025194   ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Mus musculus ENSMUSG00000032842   ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Mus musculus ENSMUSG00000023088   ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Mus musculus ENSMUSG00000022822   ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Mus musculus ENSMUSG00000030249   ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Mus musculus ENSMUSG00000030834   ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Mus musculus ENSMUSG00000032849   ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Mus musculus ENSMUSG00000040136   ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Mus musculus ENSMUSG00000020865   ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Neospora caninum NCLIV_009810   hypothetical protein
Oryza sativa 4331585   Os03g0142800
Oryza sativa 4338040   Os05g0196100
Oryza sativa 4340195   Os06g0158900
Oryza sativa 4335177   Os04g0209300
Oryza sativa 4327122   Os01g0173900
Oryza sativa 4336809   Os04g0588600
Oryza sativa 9267441   Os06g0561800
Oryza sativa 4336810   Os04g0588700
Oryza sativa 4340331   Os06g0184700
Oryza sativa 9266691   Os01g0902100
Oryza sativa 4329047   Os02g0288400
Oryza sativa 4337027   Os04g0620000
Oryza sativa 4349819   Os11g0155600
Oryza sativa 9272039   Os02g0288733
Oryza sativa 4352527   Os12g0562700
Oryza sativa 4326284   Os01g0356000
Oryza sativa 4335176   Os04g0209200
Saccharomyces cerevisiae YDR135C   ATP-binding cassette glutathione S-conjugate transporter YCF1
Saccharomyces cerevisiae YLL048C   bile acid-transporting ATPase YBT1
Saccharomyces cerevisiae YGR281W   ATP-binding cassette transporter YOR1
Saccharomyces cerevisiae YKR103W   putative multidrug transporter NFT1
Saccharomyces cerevisiae YHL035C   putative ATP-binding cassette multidrug transporter VMR1
Saccharomyces cerevisiae YLL015W   ATP-binding cassette bilirubin transporter BPT1
Schistosoma japonicum Sjp_0028030   Canalicular multispecific organic anion transporter 2, putative
Schistosoma japonicum Sjp_0028040   ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative
Schistosoma japonicum Sjp_0027990   Multidrug resistance-associated protein 1, putative
Schistosoma japonicum Sjp_0088380   Multidrug resistance-associated protein 4, putative
Schistosoma japonicum Sjp_0107410   Multidrug resistance-associated protein 4, putative
Schistosoma japonicum Sjp_0094160   ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative
Schistosoma japonicum Sjp_0121150   Multidrug resistance-associated protein 4, putative
Schistosoma japonicum Sjp_0031710   Multidrug resistance-associated protein 7, putative
Schistosoma mansoni Smp_147250.1   multidrug resistance protein
Schistosoma mansoni Smp_171740   multidrug resistance protein
Schistosoma mansoni Smp_167610   multidrug resistance protein
Schistosoma mansoni Smp_147250.2   multidrug resistance protein
Schmidtea mediterranea mk4.008607.03  
Schmidtea mediterranea mk4.005098.02   Multidrug resistance-associated protein 4
Schmidtea mediterranea mk4.000143.09  
Schmidtea mediterranea mk4.013166.00  
Schmidtea mediterranea mk4.000271.06   Multidrug resistance-associated protein 7
Schmidtea mediterranea mk4.000143.19  
Schmidtea mediterranea mk4.006999.00  
Schmidtea mediterranea mk4.012239.00  
Schmidtea mediterranea mk4.008607.04   Multidrug resistance-associated protein 4
Schmidtea mediterranea mk4.004048.07  
Schmidtea mediterranea mk4.001002.08   Putative multidrug resistance protein 1
Schmidtea mediterranea mk4.000458.08  
Schmidtea mediterranea mk4.004048.03  
Schmidtea mediterranea mk4.004048.04  
Schmidtea mediterranea mk4.001002.10  
Schmidtea mediterranea mk4.000271.05   Putative multidrug resistance associated protein
Schmidtea mediterranea mk4.001764.05  
Schmidtea mediterranea mk4.013299.00  
Schmidtea mediterranea mk4.007630.00  
Schmidtea mediterranea mk4.000458.09  
Schmidtea mediterranea mk4.005014.01  
Schmidtea mediterranea mk4.004048.01  
Schmidtea mediterranea mk4.000143.17  
Schmidtea mediterranea mk4.000143.11   Multidrug-Resistance like protein 1
Schmidtea mediterranea mk4.004048.02  
Schmidtea mediterranea mk4.002389.08   Multidrug-Resistance like protein 1
Schmidtea mediterranea mk4.013299.01  
Schmidtea mediterranea mk4.000143.18  
Schmidtea mediterranea mk4.018402.00  
Schmidtea mediterranea mk4.001764.06  
Schmidtea mediterranea mk4.000143.10  
Schmidtea mediterranea mk4.007643.00  
Schmidtea mediterranea mk4.010538.00   Multidrug-Resistance like protein 1
Schmidtea mediterranea mk4.000143.14  
Schmidtea mediterranea mk4.001764.07  
Schmidtea mediterranea mk4.004048.00  
Schmidtea mediterranea mk4.006999.02  
Schmidtea mediterranea mk4.000143.12   Multidrug-Resistance like protein 1
Schmidtea mediterranea mk4.002389.10   Putative multidrug resistance protein 1
Schmidtea mediterranea mk4.000458.07  
Schmidtea mediterranea mk4.001002.09  
Schmidtea mediterranea mk4.002389.09  
Schmidtea mediterranea mk4.002389.07  
Schmidtea mediterranea mk4.030652.00   Multidrug resistance-associated protein 4
Trypanosoma brucei gambiense Tbg972.4.2470   multidrug resistance-associated protein, putative,p-glycoprotein
Trypanosoma brucei gambiense Tbg972.4.4600   multidrug resistance protein E,p-glycoprotein
Trypanosoma brucei Tb927.8.2160   p-glycoprotein
Trypanosoma brucei Tb927.4.4490   multidrug resistance protein E
Trypanosoma brucei Tb11.v5.0734   multidrug resistance-associated protein, putative
Trypanosoma brucei Tb927.4.2510   multidrug resistance-associated protein, putative
Trypanosoma congolense TcIL3000_0_01290   multidrug resistance protein A
Trypanosoma congolense TcIL3000_0_08390   multidrug resistance-associated protein, putative
Trypanosoma cruzi TcCLB.508965.14   multidrug resistance protein E, putative
Trypanosoma cruzi TcCLB.506559.100   multidrug resistance-associated protein, putative
Trypanosoma cruzi TcCLB.510231.29   multidrug resistance-associated protein, putative
Trypanosoma cruzi TcCLB.510785.10   hypothetical protein
Toxoplasma gondii TGME49_320460   ABC transporter transmembrane region domain-containing protein
Theileria parva TP02_0940   ABC transporter, putative
Theileria parva TP04_0914   ABC transporter, putative
Theileria parva TP02_0390   ABC transporter, putative
Theileria parva TP03_0165   ABC transporter, putative
Theileria parva TP02_0388   ABC transporter, putative
Theileria parva TP01_0011   ABC transporter, putative
Theileria parva TP02_0017   ABC transporter, putative
Theileria parva TP03_0007   ABC transporter, putative
Theileria parva TP02_0016   ABC transporter, putative
Theileria parva TP02_0951   ABC transporter, putative
Theileria parva TP02_0391   ABC transporter, putative
Theileria parva TP03_0864   ABC transporter, putative
Theileria parva TP04_0021   ABC transporter, putative

Essentiality

EHI_100320 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.2160 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.2160 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.2160 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.8.2160 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.2510 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.2510 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.2510 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.2510 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.4490 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.4490 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.4490 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.4.4490 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F21G4.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F14F4.3 Caenorhabditis elegans larval lethal wormbase
CELE_F14F4.3 Caenorhabditis elegans slow growth wormbase
TGME49_320460 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Canalicular multispecific organic anion transporter 1 Compounds References
Mus musculus ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Compounds References
Rattus norvegicus Canalicular multispecific organic anion transporter 2 Compounds References
Homo sapiens Multidrug resistance associated protein Compounds References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Compounds References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 Compounds References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Compounds References
Rattus norvegicus ATP-binding cassette sub-family C member 8 Compounds References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Compounds References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Compounds References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Compounds References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0333 1 1
0.0122 0.55 1
0.0204 0.2853 0.3044
0.0042 0.2624 0.0156
0.0124 0.4598 1
0.0034 0.3473 0.3473
0.0037 0.4135 1
0.0025 0.4773 0.4773
0.0314 1 1
0.0254 0.2524 0.2523
0.0021 1 1
0.0028 0.587 0.5621
0.0018 0.3253 0.1497
0.013 0.2798 0.0639
0.0042 0.4005 0.3887
0.0029 0.3746 0.3746
0.0329 1 1
0.0072 0.5781 0.5781
0.0032 0.2801 1
0.0105 0.3323 1
0.01 0.3123 0.0834
0.0029 0.4206 0.4206
0.0018 1 1
0.0062 0.3447 1
0.0087 1 1
0.0029 0.5276 0.5082
0.0014 0.4403 0.7134
0.0043 1 1
0.0326 1 1
0.0468 1 1
0.00216708 0.391852 0
0.0212 0.638 1
0.0033 0.3399 0.3399
0.011 0.2652 0.2221
0.0131 0.7391 0.7391
0.0025 0.5236 0.5236
0.0018 0.2763 0.1224
0.0014 1 0.5
0.0029 0.4176 0.4176
0.0272 1 1
0.0021 1 1
0.0133 0.8474 0.8116
0.0236 0.2671 1
0.0249 0.289 1
0.0022 0.3523 0
0.0026 0.523 0.523
0.0066 0.7847 0.9757
0.0017 1 1
0.0069 0.3113 0.1099
0.0112 0.6284 0.6284
0.0129 0.7337 0.7337
0.0222 0.2627 1
0.0142 0.3121 0.0601
0.0119 0.3356 0.0687
0.00398041 1 1
0.0016 0.3112 0
0.0107 1 1
0.00411359 1 1
0.0072 0.3197 1
0.0134 0.595 1
0.0014 0.5192 0.5
0.0496 0.7544 1
0.0249 1 1
0.0222 0.6496 1
0.0017 1 1
0.0027 0.3241 1
0.0027 0.5383 0.5383
0.0085 0.3117 0.2991
0.0306 1 1
0.0109 0.3306 0.0759
0.0105 0.2629 0.2132
0.0496 0.7544 1
0.0552 0.7018 1
0.0024 0.5238 0.5238
0.0029 0.2801 1
0.0072 0.3197 1
0.00151706 1 1
0.002 1 1
0.0096 0.3154 0.0787
0.0038 1 1
0.0342 1 1
0.0041 0.7213 0
0.0038 0.9655 0
0.0057 1 1
0.0026 0.5238 0.5238
0.0037 1 1
0.0024 0.739 0
0.0021 0.3522 0
0.0547 1 1
0.0021 0.7343 0
0.0017 0.4386 0
0.00127836 1 0.5
0.0021 1 1
0.0053 0.2821 0.2474
0.0112 0.7776 0.7629
0.0038 1 1
0.0239 0.4454 1
0.0021 1 1
0.0049 0.4962 0.4962
0.0022 0.7636 0
0.0109 0.4908 0.7024
0.0015 0.6604 0.6604
0.0074 0.3922 1
0.0394 1 1
0.0254 1 1
0.0206 0.2785 0.2694
0.0017 1 0.5
0.0129 0.2892 0.2184
0.0121 0.6542 0.6518
0.0017 1 1
0.0017 1 1
0.0069 0.3246 0.1099
0.0014 1 0.5
0.01 0.8093 0
0.0121 0.3281 0.07
0.0463 0.5415 1
0.0066 0.7847 0.9757
0.0137 0.2918 0.2432
0.0044 0.4042 0.3921
0.0021 1 1
0.0021 1 1
0.0021 1 1
0.013 0.2798 0.0639
0.0043 1 0.5
0.0145 0.3121 0.0598
0.003 0.4199 0.4199
0.0125 0.3111 0.0681
0.0064 0.3356 0.1426
0.0031 0.2556 1
0.0064 0.2948 0.2979
0.005 0.2958 0.0156
0.0085 0.3117 0.2201
0.0017 1 1
0.0226 0.2607 0.2473
0.0106 0.628 0.628
0.003 0.4212 0.4212
0.0062 0.2691 0.1236
0.0576 1 1
0.0017 1 1
0.0034 0.347 0.347
0.0022 0.3523 0
0.0445 1 1
0.0116 0.6247 0.6247
0.0045 1 1
0.00216708 0.391852 0
0.0017 1 1
0.0015 1 0.5
0.0068 0.2916 1
0.003 1 1
0.0199 0.2537 0.2671
0.0021 1 1
0.0136 0.413 0.5
0.0025 0.5236 0.5236
0.0082 1 1
0.0055 0.4422 1
0.0034 0.4278 0.4133
0.0021 1 1
0.0129 0.744 0.744
0.0073 0.3313 1
0.0116 0.623 0.623
0.0033 0.3097 0.2613
0.0021 1 1
0.0317 0.6042 1
0.047 0.581 1
0.0021 1 1
0.0044 0.7213 0
0.0326 1 1
0.0029 0.414 0.414
0.0071 0.3079 0.5354
0.0021 1 1
0.00127836 1 0.5
0.0075 0.6704 1
0.0018 0.2763 0.1224
0.0103 0.3262 1
0.0017 1 1
0.0018 0.3332 0.3332
0.0298 0.4341 1
0.0021 1 1
0.0326 1 1
0.0033 0.3446 0.3446
0.0069 0.6516 0.6516
0.0017 1 1
0.0021 1 1
0.0015 1 1
0.0018 1 1
0.0017 1 1
0.0026 0.5131 0.5131
0.0021 0.7677 0.7536
0.0086 0.3164 0.3043
0.003 0.421 0.421
0.0481 0.7739 1
0.0083 0.2908 0.0937
0.0111 0.2941 0.0709
0.0022 0.3822 0
0.0077 1 1
0.0051 0.3327 1
0.0379 1 1
0.0099 0.2891 0.278
0.00216708 0.391852 0
0.0537 1 1
0.0026 0.5115 0.5115
0.0021 1 1
0.0076 0.3114 0.1008
0.0021 1 1
0.0017 1 1
0.0295 0.3411 1
0.0552 0.7018 1
0.0138 0.3706 0.5
0.0022 0.7837 0.7837
0.0034 0.3373 0.3373
0.0095 0.4779 0.5731
0.0064 0.2606 0.2093
0.0025 1 1
0.0021 1 1
0.0072 0.3114 0.2007
0.0021 1 1
0.0014 0.3035 0.5
0.0066 0.2926 0.1168
0.0328 1 1
0.0109 1 1
0.0024 0.524 0.524
0.0017 1 1
0.033 1 1
0.0063 0.7214 0
0.0478 1 1
0.0324 1 1
0.0336 1 1
0.0399 0.8745 1
0.0136 0.7656 0.7644
0.0241 1 1
0.0027 0.5234 0.5234
0.0021 1 1
0.0021 1 1
0.0172 0.6923 1
0.0026 0.523 0.523
0.0113 0.6173 0
0.0311 1 1
0.0029 0.4203 0.4203
0.0034 0.3479 0.3479
0.0022 0.3819 0
0.0033 1 1
0.0041 0.7213 0
0.0082 0.4816 0.4816
0.0113 0.3358 0.3084
0.0531 1 1
0.0021 1 1
0.0046 1 1
0.0088 0.2555 0.2093
0.0061 1 1
0.0021 1 1
0.0079 0.3233 0.0964
0.0113 0.3358 0.3084
0.0077 0.3704 1
0.0199 0.2537 0.2671
0.0022 0.5084 0
0.0337 1 1
0.0031 0.3619 0.3619
0.0021 1 1
0.0068 0.3152 0.2721
0.0203 0.381 1
0.0114 1 1
0.0496 0.7544 1
0.0125 0.6026 0.6026
0.0206 0.2586 0.2286
0.0028 1 1
0.0105 1 1
0.0059 0.3406 0.3406
0.0222 0.6496 1
0.0066 0.7847 0.9757
0.0299 1 1
0.0021 1 1
0.0015 1 0.5
0.0021 1 1
0.0121 1 0.5
0.0016 0.5856 1
0.0066 0.3195 0.1162
0.0017 1 1
0.002 0.2674 0
0.0022 0.382 0
0.008 0.6703 1
0.0014 1 0.5
0.0292 1 1
0.0031 0.2995 0.2995
0.0101 0.3118 0.0779
0.013 0.6815 0.6815
0.003 0.4141 0.4141
0.0137 0.312 0.0645
0.0021 1 1
0.0131 1 0.5
0.0121 0.5995 1
0.0015 1 0.5
0.0091 0.3123 0.0874
0.0088 0.3217 0.085
0.0321 1 1
0.0096 0.3409 1
0.0022 0.7647 0
0.0061 0.2905 0.3341
0.0112 0.2949 0.0702
0.0131 0.3121 0.0647
0.002 1 1
0.0068 0.2729 1
0.017 0.2978 0.2977
0.0129 0.312 0.0666
0.013 0.2921 0.3013
0.0289 1 1
0.0115 0.6271 0.6271
0.0014 1 0.5
0.0122 0.3749 1
0.0021 1 1
0.0103 0.3325 0.0803
0.0129 1 1
0.0088 0.2555 0.2093
0.0226 0.2574 0.2421
0.0021 1 1
0.0017 1 1
0.0059 0.2998 1
0.0098 0.3118 0.0808
0.0079 1 1
0.0316 1 1
0.0017 1 1
0.0017 1 1
0.0079 0.3933 1
0.0027 0.5232 0.5232
0.0098 0.3294 0.0813
0.0017 0.4386 0
0.0126 0.7331 0.7331
0.0061 1 1
0.0018 1 1
0.0136 0.2913 0.2264
0.0031 0.2562 1
0.0025 0.5224 0.5224
0.0531 1 1
0.0017 1 1
0.0113 0.3256 0.0712
0.0071 1 1
0.0253 1 1
0.00216708 0.391852 0
0.0017 0.3422 1
0.0022 0.3524 0
0.0017 0.2997 0.5
0.0294 1 1
0.0021 1 1
0.0179 1 1
0.0139 0.3719 1
0.0125 0.7166 0.7166
0.0012292 1 1
0.0021 1 1
0.0203 0.381 1
0.0074 0.3594 1
0.0017 1 1
0.0021 1 1
0.0014 1 0.5
0.0014 0.4468 0.5
0.0112 0.7286 0.703
0.013 0.4186 0.4186
0.0333 1 1
0.006 0.3427 0.5387
0.012 1 0.5
0.013 0.2798 0.0639
0.0021 0.3604 0
0.0065 0.3661 0.3116
0.0212 0.2836 0.2335
0.0249 0.289 1
0.0044 0.7213 0
0.0598 1 1
0.0021 1 1
0.0122 0.2698 0.2093
0.0547 1 1
0.0102 0.9058 0.9058
0.0079 0.3233 0.0964
0.0395 1 1
0.0021 1 1
0.0021 1 1
0.0174 1 1
0.0017 1 1
0.0093 0.9625 1
0.0033 1 1
0.0504 1 1
0.0119 0.2981 0.0721
0.00216708 0.391852 0
0.0326 1 1
0.0087 0.2888 0.2279
0.0021 1 1
0.0025 0.5111 0.5111
0.0014 0.447 0.5
0.0018 1 1
0.0068 0.2636 0.2586
0.0097 0.3118 0.0802
0.0019 0.6679 0.6679
0.0105 1 0.5
0.0029 0.3614 0.3614
0.003 1 1
0.0068 0.2729 1
0.046 1 1
0.0058 1 1
0.0295 0.3411 1
0.014 0.3719 1
0.0021 1 1
0.0076 0.324 0.3011
0.0014 1 0.5
0.0026 0.4731 0.4731
0.0029 0.4204 0.4204
0.0017 1 1
0.0017 1 1
0.0577 1 1
0.0015 1 1
0.0065 0.2748 0.269
0.0017 1 1
0.0133 0.3775 0.7844
0.035 1 1
0.0148 0.3719 1
0.0501 1 1
0.0033 0.3446 0.3446
0.0019 0.3223 0.26
0.0018 0.3253 0.1498
0.0018 1 1
0.0176 1 1
0.0101 0.3123 0.0813
0.0014 1 0.5
0.0068 0.3673 0.5513
0.0067 0.3488 0.1311
0.0114 0.5215 1
0.0017 1 1
0.0098 0.3288 0.0796
0.0066 0.7847 0.9757
0.0137 0.7704 0.7212
0.0053 1 1
0.0043 0.575 0.575
0.005 0.3447 1
0.0043 0.3296 1
0.0038 0.6282 1
0.014 0.7708 0.7167
0.0021 1 1
0.0051 0.513 0.513
0.003 0.5546 0.5353
0.0034 0.3466 0.3466
0.0038 0.2684 0.0156
0.0108 0.3077 0.074
0.0086 0.322 0.306
0.0053 0.2821 0.2474
0.00562135 0.688565 1
0.003 0.2801 0.6435
0.0083 0.867 0.867
0.006 0.3427 0.5387
0.0135 0.3121 0.0617
0.0053 0.4322 0.4322
0.0021 1 1
0.002 1 1
0.0062 0.2697 0.1246
0.0021 1 1
0.0254 1 1
0.0115 0.3198 0.0734
0.00156178 1 1
0.0069 0.2852 1
0.0531 1 1
0.0072 0.3704 1
0.0125 0.3192 0.0657
0.0101 0.3024 0.2558
0.0075 0.5858 0.5858
0.0066 1 1
0.0068 0.3673 0.5513
0.0034 0.3792 0.2079
0.0017 1 1
0.0027 0.4078 0
0.0061 1 1
0.0021 1 1
0.0021 1 1
0.0057 1 1
0.0039 0.6955 0.6955
0.0129 0.2967 0.0638
0.0033 0.7174 0.6947
0.0019 1 1
0.0017 1 1
0.0015 1 1
0.0017 1 1
0.0087 0.9993 1
0.002 1 1
0.0271 0.2507 0.2507
0.0178 1 1
0.0025 0.5238 0.5238
0.0021 1 1
0.0184 1 1
0.0115 0.3124 0.0743
0.0124 1 1
0.0021 1 1
0.0038 0.2684 0.0156
0.0145 0.3255 0.0585
0.0032 0.2801 1
0.008 0.3122 0.0975
0.0504 1 1
0.0099 0.3288 0.0797
0.00216708 0.391852 0
0.0377 0.3629 1
0.0129 1 1
0.0021 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EHI_100320 (Entamoeba histolytica), multidrug resistance protein, putative
Title for this comment
Comment