Detailed view for EHI_098850

Basic information

TDR Targets ID: 805032
Entamoeba histolytica, protein phosphatase regulatory subunit, putative
Source Database / ID:  AmoebaDB  

pI: 6.9665 | Length (AA): 324 | MW (Da): 38144 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03095   Phosphotyrosyl phosphate activator (PTPA) protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0019211   phosphatase activator activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 308 2ixm (A) 23 322 41.00 0 1 1.61829 -1.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_127213)

Species Accession Gene Product
Arabidopsis thaliana AT4G08960   phosphotyrosyl phosphatase activator (PTPA) family protein
Babesia bovis BBOV_IV010340   phosphotyrosyl phosphatase activator, putative
Brugia malayi Bm1_28280   protein phosphatase 2A, regulatory subunit B'
Candida albicans CaO19.14084   Resistant to Rapamycin Deletion
Candida albicans CaO19.14195   rapamycin sensitivity
Candida albicans CaO19.6792   Resistant to Rapamycin Deletion
Candida albicans CaO19.6933   rapamycin sensitivity
Caenorhabditis elegans CELE_Y71H2AM.20   Protein Y71H2AM.20, isoform B
Cryptosporidium hominis Chro.10277   phosphotyrosyl phosphatase activator protein-related
Cryptosporidium parvum cgd1_2470   phosphotyrosyl phosphatase activator protein-related
Dictyostelium discoideum DDB_G0270036   phosphotyrosyl phosphatase activator
Dictyostelium discoideum DDB_G0279655   hypothetical protein
Drosophila melanogaster Dmel_CG3289   Phosphotyrosyl phosphatase activator
Echinococcus granulosus EgrG_000242700   serine:threonine protein phosphatase 2A
Entamoeba histolytica EHI_098850   protein phosphatase regulatory subunit, putative
Echinococcus multilocularis EmuJ_000242700   serine:threonine protein phosphatase 2A
Giardia lamblia GL50803_10612   Phosphotyrosyl phosphatase activator protein, putative
Homo sapiens ENSG00000119383   protein phosphatase 2A activator, regulatory subunit 4
Leishmania braziliensis LbrM.07.0190   protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative
Leishmania donovani LdBPK_070350.1   protein phosphatase 2A, regulatory subunit B, putative
Leishmania infantum LinJ.07.0350   protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative
Leishmania major LmjF.07.0190   protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative
Leishmania mexicana LmxM.07.0190   protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative
Loa Loa (eye worm) LOAG_07359   hypothetical protein
Mus musculus ENSMUSG00000039515   protein phosphatase 2A activator, regulatory subunit B
Neospora caninum NCLIV_015300   phosphotyrosyl phosphatase activator, putative
Oryza sativa 4340511   Os06g0219800
Onchocerca volvulus OVOC2182   Putative phosphotyrosyl phosphatase activator
Plasmodium berghei PBANKA_1014600   serine/threonine protein phosphatase 2A activator, putative
Plasmodium falciparum PF3D7_1430100   serine/threonine protein phosphatase 2A activator
Plasmodium knowlesi PKNH_1328600   serine/threonine protein phosphatase 2A activator, putative
Plasmodium vivax PVX_085035   serine/threonine protein phosphatase 2A activator, putative
Plasmodium yoelii PY01269   protein phosphatase 2a, regulatory subunit b'
Saccharomyces cerevisiae YIL153W   peptidylprolyl isomerase RRD1
Saccharomyces cerevisiae YPL152W   peptidylprolyl isomerase RRD2
Schistosoma japonicum Sjp_0303020   ko:K01802 peptidylprolyl isomerase [EC5.2.1.8], putative
Schistosoma mansoni Smp_166290   phosphotyrosyl phosphatase activator
Schmidtea mediterranea mk4.000519.10   Putative phosphotyrosyl phosphatase activator
Trypanosoma brucei gambiense Tbg972.8.1320   protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative
Trypanosoma brucei Tb927.8.1710   protein phosphatase 2A, regulatory subunit B, putative
Trypanosoma congolense TcIL3000_8_1600   protein phosphatase 2A, regulatory subunit B, putative
Trypanosoma cruzi TcCLB.505071.90   protein phosphatase 2A, regulatory subunit B, putative
Trypanosoma cruzi TcCLB.511395.30   protein phosphatase 2A, regulatory subunit B, putative
Toxoplasma gondii TGME49_283720   phosphotyrosyl phosphate activator (ptpa) protein
Theileria parva TP01_0695   phosphotyrosyl phosphatase activator, putative
Trichomonas vaginalis TVAG_216210   phosphotyrosyl phosphatase activator, putative

Essentiality

EHI_098850 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.1710 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.1710 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.1710 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.1710 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y71H2AM.20 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y71H2AM.20 Caenorhabditis elegans larval arrest wormbase
CELE_Y71H2AM.20 Caenorhabditis elegans slow growth wormbase
CELE_Y71H2AM.20 Caenorhabditis elegans sterile wormbase
TGME49_283720 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein phosphatase 2A activator, regulatory subunit 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_098850 (Entamoeba histolytica), protein phosphatase regulatory subunit, putative
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