Detailed view for EHI_169580

Basic information

TDR Targets ID: 805223
Entamoeba histolytica, nucleoside transporter, putative
Source Database / ID:  AmoebaDB  

pI: 6.6314 | Length (AA): 379 | MW (Da): 42764 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01733   Nucleoside transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:1901642   GO:nucleoside transmembrane transport  

GO:0016021   integral to membrane  
GO:0005337   nucleoside transmembrane transporter activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 372 4zp0 (A) 30 379 17.00 0 0.2 1.01693 0.35
4 114 3rko (M) 119 228 34.00 0.52 0.03 0.137976 1.9
197 371 4jr9 (A) 17 212 11.00 0.0023 0.39 0.602341 -0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_127378)

Species Accession Gene Product
Arabidopsis thaliana AT1G70330   equilibrative nucleotide transporter 1
Brugia malayi Bm1_09370   hypothetical protein
Brugia malayi Bm1_38755   Nucleoside transporter family protein
Candida albicans CaO19.4174   possible nucleoside transporter
Candida albicans CaO19.11650   possible nucleoside transporter
Caenorhabditis elegans CELE_K09A9.3   Protein ENT-2
Caenorhabditis elegans CELE_ZK809.4   Protein ENT-1, isoform C
Caenorhabditis elegans CELE_F36H2.2   Protein ENT-7, isoform B
Caenorhabditis elegans CELE_F44D12.9   Protein ENT-4, isoform B
Dictyostelium discoideum DDB_G0283439   equilibrative nucleoside transporter family protein
Drosophila melanogaster Dmel_CG31911   Equilibrative nucleoside transporter 2
Drosophila melanogaster Dmel_CG11907   Equilibrative nucleoside transporter 1
Echinococcus granulosus EgrG_000609000   equilibrative nucleoside transporter 3
Echinococcus granulosus EgrG_000609200   equilibrative nucleoside transporter
Entamoeba histolytica EHI_169580   nucleoside transporter, putative
Echinococcus multilocularis EmuJ_001038200   equilibrative nucleoside transporter 3
Echinococcus multilocularis EmuJ_000609200   equilibrative nucleoside transporter protein
Echinococcus multilocularis EmuJ_000609000   equilibrative nucleoside transporter 3
Giardia lamblia GL50803_96818   Hypothetical protein
Homo sapiens ENSG00000174669   solute carrier family 29 (equilibrative nucleoside transporter), member 2
Homo sapiens ENSG00000198246   solute carrier family 29 (equilibrative nucleoside transporter), member 3
Homo sapiens ENSG00000112759   solute carrier family 29 (equilibrative nucleoside transporter), member 1
Loa Loa (eye worm) LOAG_10484   hypothetical protein
Loa Loa (eye worm) LOAG_13152   hypothetical protein
Loa Loa (eye worm) LOAG_07950   hypothetical protein
Mus musculus ENSMUSG00000020100   solute carrier family 29 (nucleoside transporters), member 3
Mus musculus ENSMUSG00000024891   solute carrier family 29 (nucleoside transporters), member 2
Mus musculus ensembl-mmu:ENSMUSG00000023942   solute carrier family 29 (nucleoside transporters), member 1
Oryza sativa 4344923   Os08g0205200
Onchocerca volvulus OVOC4811   Equilibrative nucleoside transporter, putative homolog
Onchocerca volvulus OVOC1837   Equilibrative nucleoside transporter, putative homolog
Saccharomyces cerevisiae YAL022C   Fun26p
Schistosoma japonicum Sjp_0210930   Equilibrative nucleoside transporter 3, putative
Schmidtea mediterranea mk4.014343.00  
Schmidtea mediterranea mk4.012010.00  
Schmidtea mediterranea mk4.008560.02   Equilibrative nucleoside transporter, putative
Trichomonas vaginalis TVAG_483030   equilibrative nucleoside transporter, putative
Trichomonas vaginalis TVAG_441760   equilibrative nucleoside transporter, putative
Trichomonas vaginalis TVAG_341290   equilibrative nucleoside transporter, putative
Trichomonas vaginalis TVAG_101510   equilibrative nucleoside transporter, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Equilibrative nucleoside transporter 2 Compounds References
Homo sapiens solute carrier family 29 (equilibrative nucleoside transporter), member 1 Compounds References
Rattus norvegicus Equilibrative nucleoside transporter 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.3126 1 1
0.1105 0.3231 1
0.1185 0.4772 1
0.0245 0.3029 0.5999
0.6125 1 1
0.0098 0.2832 1
0.084 0.4916 1
0.0952 1 1
0.1968 1 1
0.1695 0.679 1
0.0098 1 0.5
0.343 1 1
0.5087 1 1
0.4556 1 1
0.1505 1 1
0.5854 1 1
0.5656 1 1
0.5353 1 1
0.0835 0.8216 1
0.1735 1 1
0.1885 1 1
0.0322 0.2875 1
0.1562 0.7054 1
0.0246 0.3029 0.5999
0.4805 1 1
0.1272 0.5006 1
0.0979 0.9349 1
0.1424 0.487 1
0.0419 0.4926 0.98
0.0407 1 1
0.4451 1 1
0.1599 0.378 1
0.1598 0.3085 1
0.1827 1 1
0.1776 0.5461 0.5461
0.0281 0.5313 1
0.2135 1 1
0.5353 1 1
0.3177 1 1
0.0428 0.5132 1
0.1753 1 1
0.0845 0.3363 1
0.3741 1 1
0.0914 0.4484 1
0.2302 0.5747 1
0.0098 1 0.5
0.1178 0.841 1
0.1769 1 1
0.0188 1 0.5
0.1799 0.8002 0.8
0.0579 0.5733 1
0.0449 0.4909 1
0.1866 1 1
0.1838 1 1
0.189 0.2759 1
0.2569 1 1
0.083 0.8981 1
0.0408 0.4828 1
0.1422 1 1
0.2044 1 1
0.7794 0.3351 1
0.1099 0.9004 1
0.3642 0.5903 1
0.1706 1 1
0.0281 0.5313 1
0.4556 1 1
0.1088 0.6305 0.993
0.051 0.5824 1
0.1355 0.4042 1
0.1101 0.6514 1
0.7359 0.3334 1
0.2767 0.9551 1
0.1854 0.727 1
0.2056 1 1
0.0655 1 1
0.1785 1 1
0.0579 0.5747 1
0.0553 0.7011 1
0.0325 0.4053 0.8021
0.2546 1 1
0.1732 1 1
0.0845 0.3363 1
0.1193 0.2862 1
0.0666 0.7349 1
0.0281 0.3418 1
0.0079 0.6152 0.5
0.1177 0.9926 1
0.3535 1 1
0.1251 0.3048 1
0.024 0.303 0.6
0.0624 1 0.5
0.0752 0.4457 1
0.4784 0.4093 1
0.0081 1 0.5
0.0281 0.2864 0.2864
0.1185 0.4772 1
0.1829 1 1
0.0081 0.4299 0.8082
0.0323 0.2799 1
0.0098 1 1
0.0239 0.3114 0.8849
0.0245 0.2981 0.593
0.0752 0.4445 1
0.0208 1 1
0.0098 1 0.5
0.1813 1 1
0.008 1 0.5
0.0098 0.315 1
0.354 1 1
0.1094 0.2657 1
0.1774 1 1
0.1776 0.5461 0.5461
0.0098 1 0.5
0.0567 0.3032 0.9428
0.1786 1 1
0.505 1 1
0.1185 0.4772 1
0.0429 0.49 1
0.1185 0.4772 1
0.0614 0.441 1
0.539 1 1
0.1652 1 1
0.0326 0.8658 1
0.0479 1 1
0.3535 1 1
0.0098 0.8185 1
0.0419 0.4431 0.9801
0.0661 0.596 1
0.0323 0.2799 1
0.0241 0.3028 0.5998
0.1786 1 1
0.3108 1 1
0.2526 1 1
0.0098 0.6041 1
0.1108 0.6512 1
0.0456 1 0.5
0.0322 0.2875 1
0.1088 0.4352 1
0.1184 0.4673 1
0.0765 1 1
0.1716 1 1
0.1091 0.9274 1
0.0581 0.4403 1
0.0752 0.4445 1
0.539 1 1
0.127 0.3329 1
0.0544 0.4403 1
0.3319 1 1
0.1792 1 1
0.7794 0.3351 1
0.3872 1 1
0.1452 1 1
0.0435 1 1
0.1086 0.9706 1
0.0988 0.3732 1
0.382 1 1
0.0861 0.9415 1
0.0528 1 1
0.149 1 1
0.1348 1 1
0.041 0.4764 1
0.1562 0.7054 1
0.1677 1 1
0.0244 0.2897 0.3839
0.1598 0.3085 1
0.0416 0.4145 0.9802
0.1087 0.9073 1
0.0416 0.4148 0.9802
0.025 0.2967 0.6
0.4784 0.4093 1
0.1968 1 1
0.0479 0.5962 1
0.0497 0.4917 1
0.2821 1 1
0.0079 0.6494 1
0.4886 0.8928 1
0.0255 0.2558 1
0.0435 0.5081 1
0.1087 0.6311 1
0.1804 1 1
0.1087 0.9039 1
0.0553 0.4406 1
0.0808 0.4835 1
0.0485 1 1
0.0323 0.2799 1
0.0098 0.4891 0.478
0.1333 1 1
0.2302 0.5747 1
0.0098 1 0.5
0.0098 1 0.5
0.1733 1 1
0.3741 1 1
0.0987 1 1
0.2302 0.5747 1
0.104762 0.407316 0.524634
0.1094 0.4327 1
0.0098 0.3239 0.3232
0.0310177 0.531782 0.52147
0.0831 0.8082 1
0.1895 0.3032 1
0.0579 0.6418 1
0.0255 0.2558 1
0.0582 1 0.5
0.5353 1 1
0.2683 1 1
0.0157 0.4277 1
0.0331 0.3316 0.7873
0.0416 0.4186 0.9802
0.1939 1 1
0.5353 1 1
0.0582 0.4707 1
0.0977 1 1
0.0753 0.6505 1
0.0663 0.3984 1
0.1599 0.378 1
0.1815 1 1
0.4784 0.4093 1
0.4027 0.8483 1
0.0388 0.4592 1
0.1309 1 1
0.127 0.3329 1
0.0132 0.5276 1
0.6698 0.6004 1
0.0669 0.3973 1
0.2017 1 1
0.0582 0.3301 1
0.0406 1 1
0.0679 1 1
0.2033 1 1
0.1194 0.3329 1
0.0098 0.6401 1
0.0977 1 1
0.1968 1 1
0.1789 1 1
0.2112 1 1
0.0752 0.701 1
0.1276 1 1
0.0924 0.7808 1
0.1815 1 1
0.1132 0.3328 1
0.0661 0.6055 1
0.1194 0.3329 1
0.1598 1 1
0.1829 1 1
0.0485 1 1
0.0778 0.2903 1
0.3535 1 1
0.5353 1 1
0.1717 1 1
0.2009 1 1
0.1806 0.5812 1
0.545 1 1
0.302 1 1
0.0582 1 0.5
0.1007 0.8374 1
0.0822 0.4911 1
0.1854 0.727 1
0.1016 1 1
0.11989 1 1
0.1852 1 1
0.149 1 1
0.0479 0.5962 1
0.2004 1 1
0.2302 0.5747 1
0.4784 0.4093 1
0.0197 1 0.5
0.0416 0.4136 0.9802
0.0665 0.6012 1
0.1802 1 1
0.0635 1 1
0.1088 0.6478 1
0.1018 1 1
0.008 0.3039 0.5
0.0495 0.5848 1
0.0581 1 0.5
0.2302 0.5747 1
0.0098 1 1
0.0661 0.7748 1
0.5353 1 1
0.0839 1 1
0.2774 1 1
0.0768 0.2944 1
0.4784 0.4093 1
0.0158 0.7635 1
0.4784 0.4093 1
0.0318 0.3273 1
0.3836 1 1
0.1252 1 1
0.4358 1 1
0.1088 0.6305 0.993
0.0765 1 1
0.1469 0.9613 1
0.0302952 0.525875 0.525875
0.6917 0.3318 1
0.1753 1 1
0.5656 1 1
0.0778 0.2903 1
0.2004 1 1
0.0835 0.4916 1
0.1184 0.4673 1
0.0579 0.5665 1
0.3634 1 1
0.3817 1 1
0.2057 1 1
0.16 0.2796 1
0.1733 1 1
0.2112 1 1
0.0242 0.2993 0.5931
0.1505 1 1
0.4886 0.8928 1
0.1359 1 1
0.4784 0.4093 1
0.0582 0.3301 1
0.1715 1 1
0.1762 1 1
0.2978 1 1
0.0279 0.5352 1
0.048815 0.366554 1
0.1909 1 1
0.4671 1 1
0.0238 0.4989 0.8829
0.0669 0.2664 1
0.2302 0.5747 1
0.0816 0.3423 1
0.0419 0.4156 0.98
0.3697 1 1
0.2042 1 1
0.0083 0.6714 1
0.4805 1 1
0.2004 1 1
0.1926 1 1
0.00949888 1 0.5
0.0889 0.8317 1
0.0571 0.6658 1
0.1184 0.4673 1
0.0265 1 0.5
0.0573 0.7259 1
0.0579 0.5744 1
0.2188 0.6169 1
0.5353 1 1
0.0242 0.2656 0.593
0.0835 0.3336 1
0.1598 0.3085 1
0.0758 0.7121 1
0.1792 1 1
0.1105 0.3231 1
0.0281 0.3418 1
0.1106 0.647 1
0.0092 1 0.5
0.0413 1 1
0.1094 0.2657 1
0.1008 0.6583 1
0.1536 1 1
0.2526 1 1
0.3929 1 1
0.1251 1 1
0.104762 0.407316 0.524634
0.0322 0.4019 0.8026
0.0874 0.9471 1
0.1713 1 1
0.1776 0.5461 0.5461
0.1794 1 1
0.156 1 1
0.0422 0.4286 1
0.0678 0.7047 1
0.2017 1 1
0.0765 1 1
0.0688 0.7006 1
0.0098 0.2844 0.2772
0.2033 1 1
0.0098 0.42 0
0.0816 0.3423 1
0.127 0.3329 1
0.3398 1 1
0.2302 0.5747 1
0.6698 0.6004 1
0.2004 1 1
0.0643 0.3862 1
0.0673 0.6294 1
0.0322 0.3684 1
0.1718 1 1
0.6917 0.3318 1
0.0323 1 1
0.1695 0.679 1
0.0752 0.4445 1
0.1417 0.8626 1
0.0188 1 0.5
0.1968 1 1
0.2164 1 1
0.0655 0.6571 1
0.0098 1 1
0.0433 0.5135 1
0.0768 0.2944 1
0.091 1 1
0.0411 0.2519 1
0.3119 1 1
0.1926 1 1
0.2178 1 1
0.1895 0.3032 1
0.0807 0.9673 1
0.0244 0.2897 0.3839
0.0918 0.7699 1
0.0835 0.6979 1
0.3126 1 1
0.0813 0.976 1
0.1892 0.7671 1
0.1599 0.378 1
0.0098 0.3018 0.5
0.0828 0.9004 1
0.0248 0.2946 0.5881
0.0579 0.6803 1
0.0759 0.8391 1
0.1546 1 1
0.0582 0.3301 1
0.1185 0.4772 1
0.0098 0.6191 0.5
0.0388 0.4592 1
0.0971 1 1
0.2004 1 1
0.2148 1 1
0.3367 1 1
0.0416 0.4145 0.9802
0.0528 1 1
0.0098 0.9363 0
0.0419 0.4626 0.98
0.0866 1 1
0.0666 0.2585 0.2668
0.1806 0.5812 1
0.0098 1 0.5
0.0098 1 1
0.3177 1 1
0.0322 0.2875 1
0.7359 0.3334 1
0.1225 0.3641 1
0.1422 1 1
0.0098 0.3499 0.3419
0.2033 1 1
0.2606 1 1
0.0310177 0.531782 0.52147
0.1829 1 1
0.0821 1 1
0.156 1 1
0.1688 1 1
0.2938 1 1
0.1599 1 1
0.0858 0.3302 1
0.3442 1 1
0.1598 1 1
0.1683 1 1
0.0098 1 0.5
0.1806 0.5812 1
0.1854 0.727 1
0.14 1 1
0.0475 0.2721 1
0.0781 1 1
0.1516 1 1
0.0914 0.4484 1
0.0808 1 0.5
0.2932 1 1
0.1854 0.727 1
0.0907 1 1
0.240957 1 1
0.2433 1 1
0.1801 1 1
0.2526 1 1
0.1939 0.5803 0.9516
0.0835 0.6979 1
0.1895 0.3032 1
0.2526 1 1
0.4784 0.4093 1
0.0738 0.8088 1
0.0181 0.7136 0.5
0.1806 0.5812 1
0.0499628 1 1
0.0553 0.7011 1
0.0635 1 1
0.032 0.3843 1
0.0241 0.2883 0.2861
0.0665 0.6012 1
0.0098 1 0.5
0.0411 0.5138 1
0.0098 1 1
0.3033 1 1
0.0098 1 1
0.0088 0.3478 1
0.017 0.3867 1
0.0326 0.9849 1
0.2594 1 1
0.0717 0.7338 1
0.1804 1 1
0.207 1 1
0.1191 0.4772 1
0.2526 1 1
0.0571 1 1
0.3642 0.5903 1
0.0695 0.8262 1
0.1266 0.2554 1
0.5353 1 1
0.0444 0.7216 1
0.0302952 0.525875 0.525875
0.0582 0.4707 1
0.1759 1 1
0.0098 1 1
0.1786 0.3287 1
0.0577 0.5732 1
0.2606 1 1
0.2228 1 1
0.1968 1 1
0.14 1 1
0.0775 0.5289 1
0.0665 0.3062 1
0.1892 0.7671 1
0.0098 1 1
0.0778 0.4077 1
0.1939 1 1
0.0325 0.257 0.7961
0.0148 0.3178 1
0.4556 1 1
0.1702 1 1
0.0333 0.4045 1
0.0322 0.3947 1
0.2526 1 1
0.1604 1 1
0.1799 1 1
0.0752 0.4445 1
0.0751 0.7009 1
0.0333 0.4045 1
0.5353 1 1
0.0662 0.4044 1
0.2004 1 1
0.0281 0.2864 0.2864
0.0323 0.5782 1
0.3926 1 1
0.6917 0.3318 1
0.0176 0.3073 0.5201
0.1679 1 1
0.0652 0.7476 1
0.2606 1 1
0.1605 0.2773 1
0.0643 0.3862 1
0.0569 0.8249 1
0.0579 0.3724 1
0.0098 1 0.5
0.008 0.5369 0.5
0.5353 1 1
0.1085 1 1
0.0553 0.7011 1
0.0098 0.3122 1
0.0083 0.3552 0.5
0.0688 0.9347 1
0.1748 1 1
0.1001 0.8349 1
0.0143 0.6947 1
0.127 0.3329 1
0.0416 0.4928 0.9802
0.1604 1 1
0.008 0.539 1
0.0265 1 0.5
0.2331 1 1
0.1829 1 1
0.0098 1 0.5
0.6917 0.3318 1
0.0281 0.2864 0.2864
0.1178 0.9903 1
0.0408 0.4828 1
0.0541 1 0.5
0.0317 0.3932 1
0.0092 0.6174 0
0.0494 0.2989 1
0.0152344 0.345141 1
0.0688 0.7006 1
0.0669 0.6024 1
0.027 0.2624 0.4489
0.0435 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_169580 (Entamoeba histolytica), nucleoside transporter, putative
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