Detailed view for GL50803_12102

Basic information

TDR Targets ID: 805939
Giardia lamblia, Elongation factor 1-gamma
Source Database / ID:  GiardiaDB  

pI: 6.4118 | Length (AA): 402 | MW (Da): 45217 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00043   Glutathione S-transferase, C-terminal domain
PF00647   Elongation factor 1 gamma, conserved domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0003746   translation elongation factor activity  
GO:0006414   translational elongation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 189 4glt (A) 3 200 14.00 0.015 0.87 0.662449 -0.53
1 203 4o7h (A) 4 219 12.00 0.26 1 0.677275 -0.4
3 78 1yq1 (A) 24 90 40.00 0.016 0.71 0.464255 0.53
12 190 4gf0 (B) 10 204 16.00 0 1 0.711574 -0.59
14 211 2c3n (A) 18 233 21.00 0 1 0.704837 -0.36
29 78 4q5f (A) 45 89 47.00 0.39 0.47 0.517578 0.01
36 182 3ein (A) 53 191 25.00 0.000035 0.92 0.648872 -0.34
237 401 1pbu (A) 277 436 31.00 0 1 0.789748 -0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127580)

Species Accession Gene Product
Arabidopsis thaliana AT1G09640   elongation factor EF-1 gamma subunit
Arabidopsis thaliana AT1G57720   elongation factor EF-1 gamma subunit
Babesia bovis BBOV_II000890   hypothetical protein
Brugia malayi Bm1_51865   Elongation factor 1 gamma, conserved domain containing protein
Candida albicans CaO19.2651   one of three genes similar to S. cerevisiae translation elongation factor gamma-like genes TEF4 (YKL081W) and CAM1 (YPL048W) and
Candida albicans CaO19.10174   one of three genes similar to S. cerevisiae translation elongation factor gamma-like genes TEF4 (YKL081W) and CAM1 (YPL048W) and
Caenorhabditis elegans CELE_F17C11.9   Protein EEF-1G, isoform A
Cryptosporidium hominis Chro.70492   elongation factor 1-gamma
Cryptosporidium parvum cgd7_4450   elongation factor EF1-gamma (glutathione S-transferase family)
Dictyostelium discoideum DDB_G0282979   elongation factor 1 gamma
Drosophila melanogaster Dmel_CG11901   CG11901 gene product from transcript CG11901-RC
Echinococcus granulosus EgrG_000113800   eukaryotic translation elongation factor 1
Entamoeba histolytica EHI_119540   eukaryotic translation elongation factor 1 gamma, putative
Echinococcus multilocularis EmuJ_000113800   eukaryotic translation elongation factor 1
Giardia lamblia GL50803_12102   Elongation factor 1-gamma
Homo sapiens ENSG00000254772   eukaryotic translation elongation factor 1 gamma
Leishmania braziliensis LbrM.09.1020   elongation factor-1 gamma
Leishmania donovani LdBPK_091030.1   elongation factor-1 gamma
Leishmania donovani LdBPK_091020.1   elongation factor-1 gamma
Leishmania infantum LinJ.09.1020   elongation factor-1 gamma
Leishmania infantum LinJ.09.1030   elongation factor-1 gamma
Leishmania major LmjF.09.0970   elongation factor-1 gamma
Leishmania mexicana LmxM.09.0970   elongation factor-1 gamma
Loa Loa (eye worm) LOAG_06167   hypothetical protein
Mus musculus ENSMUSG00000071644   eukaryotic translation elongation factor 1 gamma
Mus musculus 101055956   predicted gene, 29753
Neospora caninum NCLIV_064580   hypothetical protein
Oryza sativa 4328753   Os02g0220600
Oryza sativa 4328752   Os02g0220500
Oryza sativa 4341354   Os06g0571400
Plasmodium berghei PBANKA_1352000   elongation factor 1-gamma, putative
Plasmodium falciparum PF3D7_1338300   elongation factor 1-gamma, putative
Plasmodium knowlesi PKNH_1263000   elongation factor 1-gamma, putative
Plasmodium vivax PVX_082845   elongation factor 1-gamma, putative
Plasmodium yoelii PY07121   probable elongation factor 1-gamma 1
Saccharomyces cerevisiae YPL048W   Cam1p
Saccharomyces cerevisiae YKL081W   Tef4p
Schistosoma japonicum Sjp_0042030   ko:K03233 elongation factor EF-1 gamma subunit, putative
Schistosoma mansoni Smp_083410   elongation factor 1-gamma
Schmidtea mediterranea mk4.022542.00  
Schmidtea mediterranea mk4.009494.01  
Schmidtea mediterranea mk4.003090.01   Probable elongation factor 1-gamma
Schmidtea mediterranea mk4.000124.02  
Schmidtea mediterranea mk4.017970.00  
Schmidtea mediterranea mk4.004456.01  
Schmidtea mediterranea mk4.034708.00  
Schmidtea mediterranea mk4.008106.01  
Trypanosoma brucei gambiense Tbg972.11.14570   elongation factor 1 gamma, putative
Trypanosoma brucei gambiense Tbg972.11.14720   elongation factor 1 gamma, putative
Trypanosoma brucei Tb927.11.13190   elongation factor 1 gamma, putative
Trypanosoma brucei Tb427tmp.01.4750   elongation factor 1 gamma, putative
Trypanosoma congolense TcIL3000.11.13550   elongation factor 1 gamma, putative
Trypanosoma congolense TcIL3000_0_43470   elongation factor 1 gamma, putative
Trypanosoma congolense TcIL3000.11.13470   elongation factor 1 gamma, putative
Trypanosoma cruzi TcCLB.510163.20   elongation factor 1-gamma (EF-1-gamma), putative
Trypanosoma cruzi TcCLB.508521.81   elongation factor 1-gamma (EF-1-gamma), putative
Toxoplasma gondii TGME49_300140   elongation factor 1-gamma, putative
Theileria parva TP04_0492   elongation factor 1 gamma, putative

Essentiality

GL50803_12102 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.4660 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.4660 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.4660 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.4660 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.4750 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.4750 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.4750 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.4750 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F17C11.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_F17C11.9 Caenorhabditis elegans slow growth wormbase
CELE_F17C11.9 Caenorhabditis elegans sterile wormbase
PBANKA_1352000 Plasmodium berghei Essential plasmo
TGME49_300140 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier GL50803_12102 (Giardia lamblia), Elongation factor 1-gamma
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