Detailed view for GL50803_3414

Basic information

TDR Targets ID: 807659
Giardia lamblia, 5-AMP-activated protein kinase, gamma-1 subunit
Source Database / ID:  GiardiaDB  

pI: 6.4347 | Length (AA): 354 | MW (Da): 39631 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00571   CBS domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 329 2qrd (G) 12 329 22.00 0 1 1.17103 -0.39
188 322 3oco (A) 222 344 17.00 0 0.82 0.579956 -0.78
198 244 2yvy (A) 203 248 24.00 0 0.57 0.417368 -0.31
267 319 2rih (A) 10 57 48.00 0.76 0.95 0.662418 -0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128342)

Species Accession Gene Product
Arabidopsis thaliana AT1G09020   putative activator subunit of SNF1-related protein kinase
Brugia malayi Bm1_41170   loechrig isoform VII
Candida albicans CaO19.13191   release from glucose repression, invertase expression
Candida albicans CaO19.5769   corresponds to C-terminus of S. cerevisiae SNF4 and allelic CaP19.13191
Candida albicans CaO19.5768   glucose repression
Caenorhabditis elegans CELE_Y111B2A.8   Protein AAKG-1
Dictyostelium discoideum DDB_G0272542   AMP-activated protein kinase gamma subunit
Drosophila melanogaster Dmel_CG17299   SNF4/AMP-activated protein kinase gamma subunit
Echinococcus granulosus EgrG_001024900   5' AMP activated protein kinase subunit gamma
Echinococcus multilocularis EmuJ_001024900   5' AMP activated protein kinase subunit gamma
Echinococcus multilocularis EmuJ_000296200   5' AMP activated protein kinase subunit gamma
Giardia lamblia GL50803_3414   5-AMP-activated protein kinase, gamma-1 subunit
Homo sapiens ENSG00000181929   protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Homo sapiens ENSG00000106617   protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Loa Loa (eye worm) LOAG_01026   loechrig isoform VII
Mus musculus ENSMUSG00000028944   protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Mus musculus ENSMUSG00000067713   protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Oryza sativa 4335727   Os04g0401300
Oryza sativa 4334839   Os03g0856400
Saccharomyces cerevisiae YGL115W   AMP-activated serine/threonine-protein kinase regulatory subunit SNF4
Schistosoma japonicum Sjp_0205650   ko:K07200 5'-AMP-activated protein kinase, regulatory gamma subunit, putative
Schistosoma japonicum Sjp_0023410   5'-AMP-activated protein kinase subunit gamma-2, putative
Schistosoma mansoni Smp_001030   protein kinase subunit gamma
Schmidtea mediterranea mk4.001914.02   IP17340p
Schmidtea mediterranea mk4.006408.00  
Schmidtea mediterranea mk4.011592.00   IP17340p
Schmidtea mediterranea mk4.003686.01   IP17340p
Schmidtea mediterranea mk4.003686.00  
Schmidtea mediterranea mk4.002374.00  

Essentiality

GL50803_3414 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y111B2A.8 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein kinase, AMP-activated, gamma 1 non-catalytic subunit Compounds References
Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.6007 0.4809 1
0.023 0.4345 1
0.0235 0.4217 1
0.5641 0.4888 1
0.2564 0.4886 1
0.0359 0.782 1
0.4571 0.4812 1
0.1746 0.4569 1
0.5666 0.4968 1
0.0237 0.3532 1
0.131 0.3709 1
0.0281 0.4135 1
0.0136 0.3763 1
0.0135 0.9407 1
0.5836 0.4968 1
0.039 0.782 1
0.0418 0.782 1
0.0237 0.3241 1
0.5838 0.4825 1
0.0524 0.3165 1
0.565 0.4974 1
0.0245 0.367 1
0.0335 0.796 1
0.6017 0.4906 1
0.5309 0.4978 1
0.0234 0.2527 1
0.6139 0.4905 1
0.5309 0.4978 1
0.5852 0.4888 1
0.529 0.3377 1
0.011 0.3075 1
0.0237 0.8172 1
0.4571 0.4812 1
0.0385 0.5726 1
0.0413 0.782 1
0.0838 1 1
0.0359 0.782 1
0.5666 0.4968 1
0.013 0.3992 1
0.4571 0.4812 1
0.0587 1 1
0.0237 0.3241 1
0.0273 0.33 0.328
0.0978 0.3654 1
0.0522 0.4864 1
0.0136 0.9407 1
0.0237 1 1
0.0255 0.8172 1
0.0229 0.8172 1
0.0209 0.3968 1
0.565 0.4974 1
0.209 0.4782 1
0.1449 0.2553 1
0.0257 0.8172 1
0.0597 1 1
0.1091 1 1
0.0254 0.2799 1
0.1192 0.4949 1
0.1101 0.3729 1
0.0255 0.3841 1
0.5817 0.4956 1
0.0249 0.3737 1
0.0281 0.36 1
0.0281 0.5519 1
0.0336 1 1
0.0224 0.497 1
0.0249 0.4379 1
0.0235 0.3501 1
0.122 0.3708 1
0.0129948 0.470075 1
0.209 0.4782 1
0.5444 0.4825 1
0.3337 0.483 1
0.0351 0.782 1
0.6052 0.3838 1
0.5666 0.4968 1
0.0226 0.3353 1
0.0259 0.3895 1
0.4505 0.4825 1
0.515124 0.463347 1
0.5369 0.4974 1
0.0265 0.4345 1
0.0235 0.3501 1
0.5369 0.4974 1
0.5994 0.483 1
0.5836 0.4968 1
0.0228 0.286 1
0.2564 0.4886 1
0.5666 0.4968 1
0.3579 0.4823 1
0.5716 0.4823 1
0.0225 0.2808 1
0.5727 0.4823 1
0.0413 0.782 1
0.0365 0.782 1
0.0396 0.7907 1
0.0472 1 1
0.0413 0.782 1
0.11785 0.474084 1
0.0267 0.2536 1
0.1541 0.4009 1
0.0136 1 0.5
0.5309 0.4978 1
0.0405 0.782 1
0.0112 0.9407 1
0.6139 0.4905 1
0.0075 0.5672 1
0.021 0.3243 1
0.0256 0.8172 1
0.0237 0.8172 1
0.0237 0.3241 1
0.5852 0.4888 1
0.5747 0.4888 1
0.0281 0.5463 1
0.0136 0.4978 1
0.0469 0.3191 1
0.0281 0.5463 1
0.0281 0.5463 1
0.0269 0.4433 1
0.0281 0.4776 1
0.0358 0.782 1
0.1101 0.3729 1
0.4734 0.2708 1
0.0456 0.861 1
0.4847 0.4834 1
0.1101 0.3729 1
0.572 0.4906 1
0.5666 0.4968 1
0.0232 0.4278 1
0.0008 1 0.5
0.209 0.4782 1
0.5836 0.4968 1
0.026 0.2524 1
0.1101 0.3729 1
0.0136 0.3173 1
0.1101 0.3729 1
0.068 0.2536 1
0.0261 0.4392 1
0.0367 0.484 1
0.0268 0.5627 1
0.0136 1 0.5
0.5836 0.4968 1
0.0269 0.4351 1
0.0272 0.4129 1
0.034 0.782 1
0.0136 1 0.5
0.5666 0.4968 1
0.0396 0.7907 1
0.5836 0.4968 1
0.0705 1 1
0.5436 0.4906 1
0.0386 0.782 1
0.5369 0.4974 1
0.1066 1 1
0.0374 0.7998 1
0.0272 0.4129 1
0.5856 0.4912 1
0.0232 0.3438 1
0.0279 0.3195 1
0.1516 0.3827 1
0.3562 0.4973 1
0.4734 0.2708 1
0.0368 0.782 1
0.035 0.782 1
0.0255 0.5456 1
0.0706 1 1
0.0385 0.5726 1
0.0279 0.4601 1
0.0273 0.33 0.328
0.0136 1 0.5
0.0269 0.4218 1
0.6052 0.3838 1
0.11785 0.474084 1
0.5369 0.4974 1
0.0245 0.8172 1
0.0222226 0.264621 0.338386
0.011 0.3075 1
0.129 0.5024 1
0.4734 0.2708 1
0.4571 0.4812 1
0.11785 0.474084 1
0.0931 0.5192 1
0.1065 1 1
0.1516 0.3827 1
0.1516 0.3827 1
0.565 0.4974 1
0.0336 0.782 1
0.0209 0.3968 1
0.5717 0.4888 1
0.0245 0.3663 1
0.0274 0.4159 1
0.0247 0.4121 1
0.4734 0.2708 1
0.1101 0.3729 1
0.0978 0.3654 1
0.131 0.3709 1
0.209 0.4782 1
0.1179 0.5343 1
0.131 0.3709 1
0.0229 0.497 1
0.1101 0.3729 1
0.1269 0.2852 1
0.0367 0.484 1
0.024 0.5033 0.781
0.0136 0.4978 1
0.0113 0.3992 1
0.0274 0.4159 1
0.5098 0.4908 1
0.3631 0.4886 1
0.034 0.782 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier GL50803_3414 (Giardia lamblia), 5-AMP-activated protein kinase, gamma-1 subunit
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