Detailed view for GL50803_11540

Basic information

TDR Targets ID: 809139
Giardia lamblia, Hexose transporter
Source Database / ID:  GiardiaDB  

pI: 8.2024 | Length (AA): 512 | MW (Da): 56338 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00083   Sugar (and other) transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 493 4gc0 (A) 5 475 27.00 0 1 1.17697 -0.34
30 90 1jb0 (L) 71 140 43.00 0.0088 0.17 0.360941 0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126798)

Species Accession Gene Product
Arabidopsis thaliana AT4G02050   sugar transport protein 7
Arabidopsis thaliana AT3G19940   sugar transport protein 10
Arabidopsis thaliana AT3G19930   sugar transport protein 4
Arabidopsis thaliana AT5G26340   sugar transport protein 13
Arabidopsis thaliana AT1G11260   sugar transporter 1
Arabidopsis thaliana AT5G23270   sugar transport protein 11
Arabidopsis thaliana AT4G21480   sugar transporter protein 12
Arabidopsis thaliana AT1G50310   sugar transporter 9
Candida albicans CaO19.5962   sugar transporter-like protein similar to S. cerevisiae SNF3 (YDL194W) glucose sensor
Candida albicans CaO19.644   potential exons, introns downstream
Candida albicans CaO19.2021   one of a repeat of three HXT6-like genes
Candida albicans CaO19.7094   similar to S. cerevisiae RGT2 (YDL138W) and SNF3 (YDL194W) transporter-like sensors of glucose, fructose
Candida albicans CaO19_7094   hypothetical protein
Candida albicans CaO19.2023   potential hexose transporter similar to S. cerevisiae HXT6 (YDR343C)
Candida albicans CaO19.13383   sugar transporter-like protein similar to S. cerevisiae SNF3 (YDL194W) glucose sensor
Candida albicans CaO19.8258   potential exons, introns downstream
Candida albicans CaO19.8259   similar to C terminus of glucose transporter
Candida albicans CaO19.2020   potential hexose transporter similar to S. cerevisiae HXT6 (YDR343C)
Candida albicans CaO19.9572   potential hexose transporter similar to S. cerevisiae HXT6 (YDR343C)
Candida albicans CaO19.9570   potential hexose transporter similar to S. cerevisiae HXT6 (YDR343C)
Candida albicans CaO19.645   similar to C terminus of glucose transporter
Candida albicans CaO19.9571   potential hexose transporter similar to S. cerevisiae HXT6 (YDR343C)
Drosophila melanogaster Dmel_CG1380   sugar transporter 4
Drosophila melanogaster Dmel_CG6484   CG6484 gene product from transcript CG6484-RA
Escherichia coli b4031   D-xylose transporter
Giardia lamblia GL50803_11540   Hexose transporter
Oryza sativa 4342198   Os07g0106200
Oryza sativa 4333366   Os03g0594400
Oryza sativa 4344808   Os08g0178200
Oryza sativa 4326342   Os01g0567500
Oryza sativa 4326343   Os01g0567600
Oryza sativa 4347061   Os09g0416200
Oryza sativa 4343590   Os07g0559700
Saccharomyces cerevisiae YDR343C   Hxt6p
Saccharomyces cerevisiae YDR342C   Hxt7p
Saccharomyces cerevisiae YDL138W   Rgt2p
Saccharomyces cerevisiae YMR011W   Hxt2p
Saccharomyces cerevisiae YDR345C   Hxt3p
Saccharomyces cerevisiae YDL194W   Snf3p
Saccharomyces cerevisiae YHR094C   Hxt1p
Saccharomyces cerevisiae YLR081W   Gal2p
Saccharomyces cerevisiae YJR158W   Hxt16p
Saccharomyces cerevisiae YJL219W   Hxt9p
Saccharomyces cerevisiae YHR092C   Hxt4p
Saccharomyces cerevisiae YDL245C   Hxt15p
Saccharomyces cerevisiae YHR096C   Hxt5p
Saccharomyces cerevisiae YFL011W   Hxt10p
Saccharomyces cerevisiae YEL069C   Hxt13p
Saccharomyces cerevisiae YNR072W   Hxt17p
Saccharomyces cerevisiae YOL156W   Hxt11p
Saccharomyces cerevisiae YJL214W   Hxt8p
Schmidtea mediterranea mk4.065188.00  

Essentiality

GL50803_11540 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b4031 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Solute carrier family 2, facilitated glucose transporter member 1 492 aa 23.7% 465 aa Compounds References
Plasmodium falciparum hexose transporter 504 aa 24.0% 441 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0908 0.4056 0.5
0.0855 0.3965 0.5
0.0825 0.395 0.5
0.0649 0.5 0.5
0.0904 0.388 0.5
0.08 0.3562 0.5
0.0931 0.4131 0.5
0.0839 0.3687 0.5
0.0856 0.3899 0.5
0.0691 0.6563 0.5
0.0877 0.3703 0.5
0.0778 0.2723 0.4621
0.09 0.3856 0.5
0.0115 0.8254 1
0.0473 0.4582 0.5
0.0746 0.2979 1
0.0811 0.3835 0.5
0.0026 0.5 0.5
0.0788 0.3469 0.5
0.0771 0.3215 0.5
0.0761 0.7227 0.5
0.0906 0.3708 0.5
0.0917 0.76 0.5
0.0815 0.3701 0.5
0.0814 0.3388 0.5
0.0904 0.3997 0.5
0.0693 0.3086 0.5
0.0705 0.673 0.5
0.0867 0.3611 0.5
0.0933 0.3971 1
0.0017 0.5 0.5
0.0838 0.798 0.5
0.0825 0.381 0.5
0.082 0.3993 1
0.0887 0.3854 0.5
0.0006 0.5 0.5
0.0846 0.3834 0.5
0.0676 0.4278 1
0.0885 0.38 0.5
0.0614 0.4905 1
0.0026 0.5 0.5
0.0785 0.3546 0.5
0.0869 0.3613 0.5
0.0443 0.5 0.5
0.0701 0.6673 1
0.086 0.4118 1
0.0891 0.4065 0.5
0.0828 0.3611 1
0.0835 0.7944 0.5
0.0006 0.5 0.5
0.0879 0.3794 0.5
0.0006 0.5 0.5
0.0676 0.4278 1
0.0779 0.7604 0.5
0.0788 0.3469 0.5
0.0848 0.3654 1
0.0218 0.2749 0.5453
0.0824 0.7893 0.5
0.0906 0.4211 1
0.0124 0.5 0.5
0.0731 0.7159 1
0.0006 0.5 0.5
0.0662 0.6327 1
0.0937 0.3983 0.5
0.0766 0.3381 0.5
0.0006 0.5 0.5
0.0395 0.4327 1
0.0901 0.3833 0.5
0.0215 1 1
0.0854 0.368 0.5
0.0052 0.3137 0.5
0.0006 0.5 0.5
0.001 0.5 0.5
0.0602 0.2622 0.5
0.0885 0.3952 0.5
0.0705 0.2788 0.5
0.0866 0.3965 0.5
0.0934 0.355 1
0.0859 0.3771 0.5
0.0931 0.4131 0.5
0.0801 0.3419 0.5
0.0967 0.3866 0.5
0.0851 0.3655 0.5
0.0006 0.5 0.5
0.0731 0.6098 1
0.0947 0.3919 0.5
0.0916 0.4286 0.5
0.0931 0.3822 0.5
0.0945 0.3769 0.5
0.0858 0.3951 0.5
0.0789 0.351 0.5
0.0836 0.4016 1
0.0578 0.5 0.5
0.0913 0.4084 0.5
0.0872 0.3879 0.5
0.0902 0.3808 0.5
0.0731 0.7159 1
0.0906 0.3653 0.5
0.0881 0.4196 0.5
0.038 0.5 0.5
0.0006 0.5 0.5
0.0893 0.3833 0.5
0.0778 0.2723 0.4621
0.0875 0.4019 0.5
0.0858 0.401 0.5
0.0766 0.3381 0.5
0.0016 0.5 0.5
0.0924 0.363 0.5
0.0782 0.3584 1
0.0636 0.5945 0.5
0.0943 0.4376 1
0.0808 0.4976 1
0.0905 0.392 1
0.0072 0.5 0.5
0.0805 0.3768 1
0.0938 0.3795 0.5
0.0902 0.3872 0.5
0.0744 0.3371 1
0.0708 0.6913 0.5
0.0026 0.2589 0.5
0.0006 0.5 0.5
0.089 0.2727 1
0.0802 0.3726 0.5
0.0934 0.3952 0.5
0.0684 0.661 1
0.0785 0.7428 0.5
0.0737 0.7131 0.5
0.0886 0.3725 0.5
0.092 0.3639 0.5
0.0372 0.3723 0.5
0.0746 0.2979 1
0.0855 0.4048 0.5
0.0906 0.4211 1
0.0904 0.385 0.5
0.0849 0.3822 0.5
0.0808 0.3589 0.5
0.0902 0.384 0.5
0.0778 0.2723 0.4621
0.0115 0.8254 1
0.0681 0.282 0.5
0.0852 0.3794 0.5
0.0676 0.4278 1
0.0725 0.3007 0.5
0.0912 0.3836 0.5
0.0851 0.3655 0.5
0.0933 0.3903 0.5
0.0861 0.3665 1
0.0703 0.282 0.5
0.0784 0.766 0.5
0.0019 0.3675 0.5
0.0869 0.3805 0.5
0.0801 0.5193 1
0.0242 1 0.5
0.0932 0.3859 0.5
0.0919 0.3894 0.5
0.0883 0.4017 0.5
0.0847 0.3728 0.5
0.0006 0.5 0.5
0.0779 0.2877 1
0.0565 0.513 1
0.0808 0.7747 0.5
0.0911 0.3866 0.5
0.0104 0.4448 0.5
0.088 0.3774 0.5
0.0832 0.3853 0.5
0.0898 0.388 0.5
0.09 0.368 0.5
0.0856 0.3829 0.5
0.0852 0.3669 0.5
0.0891 0.3748 0.5
0.0701 0.6657 1
0.0872 0.3682 0.5
0.0699 0.3137 0.5
0.0878 0.4008 1
0.0863 0.3613 0.5
0.0759 0.7344 1
0.0692 0.2863 0.5
0.0778 0.2723 0.4621
0.0888 0.4111 1
0.0026 0.4542 0.5
0.0757 0.2571 1
0.0086 0.5 0.5
0.0786 0.3708 0.5
0.0006 0.5 0.5
0.0862 0.3709 1
0.0808 0.3589 0.5
0.0909 0.3804 0.5
0.0859 0.3889 0.5
0.0801 0.5193 1
0.0911 0.3937 0.5
0.0859 0.3676 0.5
0.0822 0.3544 0.5
0.0954 0.378 0.5
0.0152 0.339 0.5
0.0785 0.3546 0.5
0.0955 0.3879 0.5
0.0801 0.3587 0.5
0.0604 0.5795 0.5
0.0919 0.4066 0.5
0.0882 0.383 1
0.0661 0.3105 0.5
0.0693 0.2676 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier GL50803_11540 (Giardia lamblia), Hexose transporter
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