Detailed view for GL50803_15566

Basic information

TDR Targets ID: 809717
Giardia lamblia, Peter pan protein
Source Database / ID:  GiardiaDB  

pI: 10.0141 | Length (AA): 352 | MW (Da): 39581 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04427   Brix domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 198 5o9e (A) 75 251 19.00 0 0.88 0.637018 0.56
191 352 4uos (A) 16 183 15.00 0.97 0.2 0.707427 -1.19
280 350 5wsu (C) 780 850 20.00 0.24 0.01 0.524905 -1.34
287 349 5wst (A) 866 931 22.00 0.29 0.01 0.463177 -1.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127732)

Species Accession Gene Product
Arabidopsis thaliana AT5G61770   Peter Pan-like protein
Babesia bovis BBOV_III005130   Brix domain containing protein
Brugia malayi Bm1_48640   Brix domain containing protein
Candida albicans CaO19.6589   brix domain protein similar to S. cerevisiae SSF1 () and SSF2 (YDR312W) nucleolar proteins involved in ribosomal large subunit b
Caenorhabditis elegans CELE_K09H9.6   Protein LPD-6
Cryptosporidium hominis Chro.80392   RNA-binding protein
Cryptosporidium parvum cgd8_3390   S.cerevisiae Ssf2p/drosophila peter pan like protein that has an IMP4 domain at its N-terminus and is involved in rRNA processin
Dictyostelium discoideum DDB_G0285515   brix domain-containing protein
Drosophila melanogaster Dmel_CG5786   peter pan
Echinococcus granulosus EgrG_000921700   zinc finger protein 598
Echinococcus granulosus EgrG_000921600   peter pan
Entamoeba histolytica EHI_012190   brix domain containing protein
Echinococcus multilocularis EmuJ_000921600   peter pan
Echinococcus multilocularis EmuJ_000921700   zinc finger protein 598
Giardia lamblia GL50803_15566   Peter pan protein
Homo sapiens ENSG00000244165   purinergic receptor P2Y, G-protein coupled, 11
Homo sapiens ENSG00000130810   peter pan homolog (Drosophila)
Homo sapiens ENSG00000243207   PPAN-P2RY11 readthrough
Leishmania braziliensis LbrM.03.0810   peter pan protein, putative
Leishmania donovani LdBPK_030880.1   peter pan protein, putative
Leishmania infantum LinJ.03.0880   peter pan protein, putative
Leishmania major LmjF.03.0900   peter pan protein, putative
Leishmania mexicana LmxM.03.0900   peter pan protein, putative
Loa Loa (eye worm) LOAG_05530   brix domain-containing protein
Mus musculus ENSMUSG00000004100   peter pan homolog (Drosophila)
Neospora caninum NCLIV_033880   hypothetical protein
Oryza sativa 4332803   Os03g0343700
Onchocerca volvulus OVOC969   Peter pan protein homolog
Plasmodium berghei PBANKA_0711700   BRIX domain, putative
Plasmodium falciparum PF3D7_0819100   BRIX domain, putative
Plasmodium knowlesi PKNH_1312900   BRIX domain, putative
Plasmodium vivax PVX_089410   hypothetical protein, conserved
Saccharomyces cerevisiae YHR066W   Ssf1p
Saccharomyces cerevisiae YDR312W   Ssf2p
Schistosoma japonicum Sjp_0008560   ko:K08709 nuclear receptor, other families, insect, putative
Schistosoma japonicum Sjp_0310700   expressed protein
Schistosoma japonicum Sjp_0216170   ko:K08387 purinergic receptor P2Y, G protein-coupled, 11, putative
Schistosoma japonicum Sjp_0123230   hypothetical protein
Schistosoma mansoni Smp_181500   peter pan-related
Schistosoma mansoni Smp_173890   peter pan-related
Schmidtea mediterranea mk4.004364.01   Protein Peter pan
Schmidtea mediterranea mk4.000152.13   Zinc finger protein 598
Trypanosoma brucei gambiense Tbg972.3.2900   hypothetical protein, conserved
Trypanosoma brucei Tb927.3.2830   brix domain containing protein, putative
Trypanosoma congolense TcIL3000_3_1730   peter pan protein, putative
Trypanosoma cruzi TcCLB.508153.830   peter pan protein, putative
Trypanosoma cruzi TcCLB.508181.130   peter pan protein, putative
Toxoplasma gondii TGME49_273840   brix domain-containing protein
Theileria parva TP02_0441   hypothetical protein
Trichomonas vaginalis TVAG_363770   ssf, putative

Essentiality

GL50803_15566 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.2830 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.2830 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.2830 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.2830 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K09H9.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_K09H9.6 Caenorhabditis elegans larval arrest wormbase
CELE_K09H9.6 Caenorhabditis elegans larval lethal wormbase
CELE_K09H9.6 Caenorhabditis elegans slow growth wormbase
CELE_K09H9.6 Caenorhabditis elegans sterile wormbase
TGME49_273840 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens PPAN-P2RY11 readthrough Compounds References
Homo sapiens purinergic receptor P2Y, G-protein coupled, 11 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0062 0.6877 0.5
0.026 0.3198 0.8991
0.0123 0.5 0.5
0.0527 0.2639 1
0.006 1 0.5
0.0135 0.9903 1
0.0191 1 0.5
0.0075 0.6526 0.5
0.013 1 0.5
0.011 0.2548 1
0.0210987 0.946835 0.976177
0.013 0.5 0.5
0.0066 0.5 0.5
0.0074 1 0.5
0.0141 1 0.5
0.0075 1 0.5
0.0064 1 1
0.0132 0.2873 1
0.006 1 0.5
0.0479 0.2847 1
0.0073 0.2953 1
0.0065 0.5 0.5
0.0075 1 0.5
0.0075 1 0.5
0.0115 0.2501 1
0.115396 0.29061 1
0.0174178 0.363585 1
0.0061 0.3523 0.5
0.0170963 0.262781 1
0.0069 1 0.5
0.0075 1 0.5
0.0068 1 0.5
0.0166 0.2548 1
0.0222 0.3374 1
0.0265 0.3324 1
0.0068 1 0.5
0.0102 1 0.5
0.0066 1 0.5
0.0133 0.3202 0.5
0.0523 0.3077 1
0.013 0.2728 0.5
0.0527 0.2639 1
0.0125 1 1
0.0138 0.5 0.5
0.019 1 0.5
0.0075 0.5 0.5
0.0073 1 0.5
0.0210987 0.946835 0.976177
0.0694241 0.289162 1
0.0069 1 0.5
0.0075 0.5 0.5
0.0053 0.4333 0.5
0.0316 0.2936 1
0.0134 0.6511 0.5
0.0065 1 0.5
0.0067 0.5 0.5
0.0170963 0.845273 1
0.0093 0.4269 1
0.0287 0.2585 1
0.0075 1 0.5
0.0285 0.3324 1
0.0527 0.2639 1
0.0074 1 0.5
0.0170963 0.262781 1
0.045 0.2793 0.9278
0.013 0.5 0.5
0.0197 1 1
0.0068 1 0.5
0.0142 0.3776 0
0.0170963 0.262781 1
0.0075 0.6526 0.5
0.026 0.3198 0.8991
0.115396 0.29061 1
0.0222 0.3374 1
0.0191 1 0.5
0.0527 0.2639 1
0.0259 0.3331 1
0.0068 1 0.5
0.051 0.3088 1
0.0287 0.2585 1
0.0075 0.6526 0.5
0.0142 0.3056 1
0.0126 1 0.5
0.0103 0.4237 0.6218
0.011 0.2549 1
0.0527 0.2639 1
0.0065 1 0.5
0.0058 0.4314 1
0.0076 1 0.5
0.026 0.3198 0.8991
0.0076 1 0.5
0.0138 0.3285 0.5
0.045 0.2793 0.9278
0.0498 0.4681 1
0.0103 0.2635 0.6185
0.026 0.3198 0.8991
0.0072 0.5 0.5
0.0075 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier GL50803_15566 (Giardia lamblia), Peter pan protein
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