Detailed view for GL50803_17043

Basic information

TDR Targets ID: 810905
Giardia lamblia, Glyceraldehyde 3-phosphate dehydrogenase
Source Database / ID:  GiardiaDB  

pI: 7.5023 | Length (AA): 407 | MW (Da): 44583 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00044   Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
PF02800   Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016620   oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
GO:0050661   NADP binding  
GO:0051287   NAD binding  
GO:0006006   glucose metabolic process  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 372 4k9d (A) 3 338 48.00 0 1 1.43418 -0.66
12 382 4dib (A) 1 336 41.00 0 1 1.27675 -0.04
12 372 3gpd (R) 2 332 49.00 0 1 1.35818 0.1
13 50 3euw (A) 3 40 32.00 0 0.31 0.438666 -0.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_202529)

Species Accession Gene Product
Giardia lamblia GL50803_17043   Glyceraldehyde 3-phosphate dehydrogenase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Glyceraldehyde-3-phosphate dehydrogenase 333 aa 43.6% 360 aa Compounds References
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 337 aa 45.5% 358 aa Compounds References
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 361 aa 39.6% 371 aa Compounds References
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 361 aa 39.6% 371 aa Compounds References
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 347 aa 26.9% 350 aa Compounds References
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 371 aa 26.7% 360 aa Compounds References
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 359 aa 40.0% 370 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1426 0.3053 0.6833
0.1354 0.4045 0.6633
0.1216 0.3874 0
0.115 0.2697 0.6901
0.0286 0.2533 0.4203
0.1429 0.4007 0
0.0093 0.4509 0
0.0281 0.2745 0.4777
0.11101 0.304664 0.300841
0.0281 0.3234 0.4609
0.1544 0.5866 0
0.0233 0.2854 0.6435
0.1298 0.5543 0.6807
0.0105 0.3331 0
0.0261 0.3132 0.6471
0.008 0.4728 0
0.0133 0.4728 0
0.0119 0.3191 0.6162
0.0154 0.4724 0
0.0122 0.5609 0
0.0123 0.2683 0.3846
0.1461 0.5825 0.6809
0.009 0.4724 0
0.11101 0.304664 0.300841
0.1461 0.5825 0.6809
0.0283 0.2542 0.4199
0.1034 0.4996 0
0.1104 0.394 0
0.0143 0.4666 0
0.1417 0.4196 0
0.0202 0.4724 0
0.1335 0.3412 0
0.0283 0.2519 0.4201
0.1262 0.5322 0
0.0091 0.5602 0.5004
0.1298 0.5543 0.6807
0.0243 0.2844 0.6435
0.1479 0.582 0.6859
0.0262 0.3259 0.6472
0.0331315 0.576399 0.0952909
0.122147 0.47714 0.61162
0.0261 0.3286 0.6473
0.0091 0.251 0.6306
0.11101 0.304664 0.300841
0.0106 0.5757 0
0.0142 0.4724 0
0.1461 0.5825 0.6809
0.111 0.5235 0.6908
0.0278 0.2736 0.6281
0.122147 0.47714 0.61162
0.1481 0.5036 0.6847
0.0279 0.2744 0.6471
0.11101 0.304664 0.300841
0.0285 0.3027 0.3361
0.146 0.3924 0
0.0191 0.6036 0
0.0265 0.3286 0.6473
0.0323 0.3547 0
0.009 0.4724 0
0.0278 0.3238 0.5536
0.0094 0.5977 0.5894
0.1432 0.4241 0
0.0191 0.6107 0.632
0.1544 0.5866 0
0.0263 0.2885 0.6471
0.1474 0.398 0
0.0129 0.4724 0
0.11101 0.304664 0.300841
0.11101 0.304664 0.300841
0.0174838 0.435373 0.41991
0.0273 0.272 0.6471
0.1334 0.4136 0
0.0261 0.4006 0
0.0175 0.4487 0
0.0086 0.251 0.6306
0.0285 0.302 0.3362
0.1126 0.5584 0
0.0322445 0.5689 0.0907472
0.0099 0.3118 0.6259
0.0144 0.4724 0
0.11101 0.304664 0.300841
0.0379 0.3945 0.6865
0.0138 0.4067 0
0.0844 0.5123 0.6751
0.0281 0.307 0.4777
0.154 0.5093 0.695
0.0236 0.2848 0.6435
0.124 0.3674 0
0.0189 0.6316 0
0.0291 0.6011 0
0.0066 0.3929 0.6173
0.0191 0.6036 0
0.0064 0.2723 0.4915
0.0331315 0.576399 0.0952909
0.1413 0.3902 0
0.0288 0.2629 0.375
0.1216 0.5167 0
0.0278 0.2739 0.6473
0.0207 0.5991 0
0.0944 0.3174 0
0.0279 0.3055 0.6473
0.154 0.5093 0.695
0.0287 0.2642 0.371
0.00823969 0.256203 0.151179
0.0161 0.2988 0.5475
0.0187 0.4724 0
0.0091 0.4424 0
0.0093 0.4724 0
0.1461 0.5825 0.6809
0.0265 0.324 0.6335
0.0266 0.4724 0
0.0096 0.274 0.1855
0.0191 0.6036 0
0.1335 0.3412 0
0.0281 0.3 0.3539
0.11101 0.304664 0.300841
0.00829298 0.394281 0
0.0285 0.2528 0.4202
0.1449 0.5731 0.6845
0.0934 0.5 0.6779
0.0073 0.3606 0.5638
0.0281 0.2744 0.4775
0.0285 0.2707 0.3349
0.1491 0.6623 0.6599
0.0279 0.2726 0.4756
0.0185 0.4996 0
0.0161 0.2988 0.5475
0.0279 0.314 0.42
0.1251 0.4926 0
0.1461 0.5825 0.6809
0.0206 0.4724 0
0.0478 0.4818 0.6885
0.0092 0.251 0.6306
0.0161 0.2988 0.5475
0.0276 0.2688 0.5467
0.0101 0.4724 0
0.1205 0.3624 0
0.0191 0.4728 0
0.0279 0.3252 0.6471
0.0278 0.2736 0.6281
0.0264 0.3288 0.6473
0.0278 0.273 0.6281
0.0288 0.2632 0.4003
0.1334 0.4106 0
0.1256 0.3779 0
0.0155 0.4724 0
0.1104 0.394 0
0.0283 0.3255 0.4201
0.1456 0.5582 0.6866
0.1462 0.4969 0.6976
0.0186 0.4335 0
0.1285 0.4925 0
0.0073 0.3606 0.5638
0.1096 0.5567 0.687
0.0135 0.4728 0
0.1425 0.5186 0
0.0278 0.2763 0.6471
0.0285 0.2528 0.4202
0.0298 0.6101 0
0.0267 0.3286 0.6473
0.0105 0.3331 0
0.0278 0.3267 0.3348
0.115 0.2697 0.6901
0.0101 0.4724 0
0.0089 0.4724 0
0.00915871 0.394281 0
0.0154 0.4902 0
0.1461 0.5825 0.6809
0.0185 0.4996 0
0.0365 0.2703 0
0.1277 0.5559 0
0.0192 0.4724 0
0.1242 0.3742 0
0.0262 0.3251 0.6471
0.0146 0.4724 0
0.1001 0.4866 0
0.0575 0.3708 0
0.0295 0.2589 0.2667
0.1341 0.3048 0
0.1379 0.5657 0
0.0107 0.4724 0
0.0287 0.2753 0.3336
0.111 0.5235 0.6908
0.0278 0.3254 0.6473
0.0934 0.5 0.6779
0.0217677 0.394281 0
0.1335 0.3412 0
0.0304 0.4724 0
0.01 0.4246 0
0.11101 0.304664 0.300841
0.014 0.4724 0
0.1297 0.6105 0.679
0.0132 0.5895 0
0.026088 0.301105 0
0.11101 0.304664 0.300841
0.0239957 0.468043 0
0.0142 0.3197 0
0.0934 0.5 0.6779
0.0188 0.4728 0
0.0281 0.2705 0.457
0.015 0.4084 0
0.11101 0.304664 0.300841
0.1431 0.4289 0
0.1254 0.5541 0.6833
0.0183 0.6352 0
0.0287 0.2624 0.3744
0.0172 0.3272 0
0.0322445 0.5689 0.0907472
0.0281 0.2737 0.457
0.0107 0.4996 0.1372
0.11101 0.304664 0.300841
0.111 0.5235 0.6908
0.0206 0.4724 0
0.026 0.3287 0.6473
0.1215 0.5016 0
0.0268 0.3206 0.6281
0.0187 0.6334 0
0.0138 0.4728 0
0.0173 0.5609 0
0.0271 0.3219 0.6473
0.1479 0.3207 0
0.115 0.2697 0.6901
0.0173 0.3337 0.5747
0.1126 0.5649 0
0.0191 0.6036 0
0.0138 0.2905 0
0.0143 0.2774 0
0.1298 0.5543 0.6807
0.0279 0.2925 0.6471
0.0066 0.3929 0.6173
0.1183 0.394 0
0.11101 0.304664 0.300841

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier GL50803_17043 (Giardia lamblia), Glyceraldehyde 3-phosphate dehydrogenase
Title for this comment
Comment