pI: 7.1612 |
Length (AA): 340 |
MW (Da): 38610 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
94 | 251 | 2gpy (A) | 25 | 193 | 12.00 | 0 | 0.58 | 0.595406 | -0.61 |
94 | 340 | 5wp4 (A) | 253 | 482 | 23.00 | 0 | 1 | 0.914171 | 0.01 |
119 | 170 | 2h1r (A) | 18 | 66 | 35.00 | 0 | 0.67 | 0.490641 | 0.07 |
127 | 181 | 1vbf (A) | 74 | 128 | 25.00 | 0 | 0.47 | 0.362465 | 0.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127178)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G26200 | S-adenosyl-L-methionine-dependent methyltransferases superfamily protein |
Brugia malayi | Bm1_03075 | Methyltransferase-like protein |
Brugia malayi | Bm1_55010 | Methyltransferase-like protein 4 |
Candida albicans | CaO19.3676 | similar to C terminus of S. cerevisiae actin filament binding protein |
Candida albicans | CaO19.11160 | similar to C terminus of S. cerevisiae actin filament binding protein |
Caenorhabditis elegans | CELE_ZK1058.5 | Protein ZK1058.5 |
Caenorhabditis elegans | CELE_Y53F4B.42 | Protein Y53F4B.42 |
Cryptosporidium hominis | Chro.80491 | FLJ12760 protein |
Cryptosporidium parvum | cgd8_4270 | conserved protein, methylase |
Dictyostelium discoideum | DDB_G0275041 | hypothetical protein |
Dictyostelium discoideum | DDB_G0274197 | methyltransferase type 12 domain-containing protein |
Drosophila melanogaster | Dmel_CG13929 | methyltransferase-like |
Drosophila melanogaster | Dmel_CG34195 | CG34195 gene product from transcript CG34195-RA |
Echinococcus granulosus | EgrG_000506200 | Methyltransferase protein 2 |
Entamoeba histolytica | EHI_069570 | methyltransferase-like protein 2, putative |
Echinococcus multilocularis | EmuJ_000506200 | Methyltransferase protein 2 |
Giardia lamblia | GL50803_9528 | Methyltransferase like 2 |
Homo sapiens | ENSG00000206562 | methyltransferase like 6 |
Homo sapiens | ENSG00000087995 | methyltransferase like 2A |
Homo sapiens | ENSG00000123600 | methyltransferase like 8 |
Homo sapiens | ENSG00000165055 | methyltransferase like 2B |
Leishmania braziliensis | LbrM.34.3560 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_353650.1 | methyltransferase domain containing protein, putative |
Leishmania infantum | LinJ.35.3650 | hypothetical protein, conserved |
Leishmania major | LmjF.35.3600 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.34.3600 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_11363 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02021 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04036 | hypothetical protein |
Mus musculus | 52686 | methyltransferase like 2 |
Mus musculus | ENSMUSG00000041975 | methyltransferase like 8 |
Mus musculus | 67011 | methyltransferase like 6 |
Neospora caninum | NCLIV_022570 | hypothetical protein |
Oryza sativa | 4331587 | Os03g0143000 |
Onchocerca volvulus | OVOC10445 | Putative methyltransferase NSUN5 |
Plasmodium berghei | PBANKA_1461000 | methyltransferase, putative |
Plasmodium falciparum | PF3D7_1248100 | methyltransferase, putative |
Plasmodium knowlesi | PKNH_1467800 | methyltransferase, putative |
Plasmodium vivax | PVX_101295 | methyltransferase, putative |
Plasmodium yoelii | PY01571 | Drosophila melanogaster CG13929 gene product-related |
Saccharomyces cerevisiae | YOR239W | Abp140p |
Schistosoma japonicum | Sjp_0216710 | ko:K00599 GA12634-PA [EC:2.1.1.-], putative |
Schistosoma mansoni | Smp_037930 | methyltransferase-related |
Schistosoma mansoni | Smp_061500 | methyltransferase-related |
Schmidtea mediterranea | mk4.000243.04 | Methyltransferase-like protein |
Trypanosoma brucei gambiense | Tbg972.9.7000 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.9.11750 | methyltransferase domain containing protein, putative |
Trypanosoma cruzi | TcCLB.510667.50 | methyltransferase domain containing protein, putative |
Trypanosoma cruzi | TcCLB.507009.110 | methyltransferase domain containing protein, putative |
Toxoplasma gondii | TGME49_202360 | methylase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.2860 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.2860 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.2860 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.211.2860 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1461000 | Plasmodium berghei | Dispensable | plasmo |
TGME49_202360 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.