Detailed view for GL50803_8914

Basic information

TDR Targets ID: 813443
Giardia lamblia, Kinase, NEK
Source Database / ID:  GiardiaDB  

pI: 8.1803 | Length (AA): 597 | MW (Da): 66084 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 274 3c0g (B) 8 281 27.00 0 1 0.748661 -0.47
7 415 1ym7 (A) 189 622 19.00 0 1 0.795492 0.99
93 276 3byv (A) 385 561 25.00 0.000016 1 0.497608 -0.7
134 267 3vut (A) 224 365 43.00 0.0000095 0.79 0.161156 1.71
240 545 5g4x (A) 16 328 18.00 0.000000000064 1 0.618963 1.03
336 589 4o1p (A) 162 427 26.00 0.00042 1 0.563161 1.21
371 581 3b7b (A) 736 961 29.00 0.00062 1 0.532134 0.6
373 493 5kng (A) 43 167 33.00 0.000083 1 0.63538 -0.74
377 491 1n0r (A) 2 120 42.00 0.000007 1 0.62933 -0.58
408 576 1k1a (A) 125 309 27.00 0.0000000000064 1 0.511482 0.11
441 487 1k1a (A) 127 179 26.00 0 0.75 0.210827 0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_202722)

Species Accession Gene Product
Giardia lamblia GL50803_8914   Kinase, NEK

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Jak1 protein 210 aa 25.6% 207 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 27.4% 281 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 24.9% 317 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 30.8% 263 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 25.2% 294 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 33.5% 173 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 29.6% 240 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0093 0.8828 0.5
0.0064 0.3377 0.5
0.0027 1 0.5
0.0011 1 0.5
0.0012 0.5 0.5
0.0036 0.5 0.5
0.0022 0.5 0.5
0.0056 1 0.5
0.0081 0.5 0.5
0.0029 0.5 0.5
0.0012 0.5 0.5
0.0059 1 1
0.0091 1 0.5
0.0023 0.5 0.5
0.0004 0.5 0.5
0.0069 0.3067 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0008 0.5 0.5
0.0016 0.5 0.5
0.0042 0.5 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.2373
0.0039 0.9485 0.5
0.0037 1 0.5
0.0063 1 0.5
0.0003 0.5 0.5
0.0016 0.5 0.5
0.0066 0.3101 0.5
0.0039 0.5 0.5
0.0018 0.5 0.5
0.0033 1 0.5
0.0007 0.5 0.5
0.0032 0.5 0.5
0.0063 0.7244 0
0.0092 1 0.5
0.0088 0.4477 0.5
0.0061 0.6883 1
0.0026 0.5 0.5
0.0033 0.5 0.5
0.0081 1 0.5
0.0007 0.5 0.5
0.0062 0.6935 0.5
0.0067 0.5 0.5
0.0059 1 1
0.0007 0.5 0.5
0.0059 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_8914 (Giardia lamblia), Kinase, NEK
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