Detailed view for GL50803_17231

Basic information

TDR Targets ID: 813671
Giardia lamblia, Kinase, NEK
Source Database / ID:  GiardiaDB  

pI: 5.9111 | Length (AA): 1006 | MW (Da): 111471 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 431 3ncg (A) 72 491 19.00 0 1 0.581159 0.12
8 294 2vd5 (A) 69 363 17.00 0 1 0.453988 -0.49
10 297 4u3y (A) 25 311 16.00 0 1 0.491982 -0.86
186 254 3kvw (A) 315 378 39.00 0.96 0.2 0.418588 -0.37
634 1003 5leb (A) 72 470 29.00 0 1 0.563793 0.27
739 852 5cbn (A) 18 1219 38.00 0.00001 1 0.59232 -0.76
924 1004 5eil (A) 39 123 28.00 0.00000000011 1 0.579217 -2.09
924 1006 5y4f (A) 433 519 27.00 0.0000072 1 0.561205 -1.99
924 1006 4o1p (A) 26 113 29.00 0.02 1 0.511205 -1.49
928 1004 1s70 (B) 47 127 32.00 0.00027 1 0.542241 -1.46
948 1002 1ycs (B) 356 412 35.00 0.000062 1 0.598372 -1.74
952 1004 4hbd (A) 739 793 40.00 0.00002 1 0.641384 -1.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_202863)

Species Accession Gene Product
Giardia lamblia GL50803_17231   Kinase, NEK

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 22.5% 293 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 23.9% 163 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 22.0% 287 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0023 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0091 1 0.5
0.0059 1 1
0.0008 0.5 0.5
0.0032 0.5 0.5
0.0069 0.3067 0.5
0.0039 0.5 0.5
0.0093 0.8828 0.5
0.0011 1 0.5
0.0064 0.3377 0.5
0.0027 1 0.5
0.0022 0.5 0.5
0.0056 1 0.5
0.0081 0.5 0.5
0.0029 0.5 0.5
0.0036 0.5 0.5
0.0012 0.5 0.5
0.0061 0.6883 1
0.0033 0.5 0.5
0.0026 0.5 0.5
0.0063 0.7244 0
0.0092 1 0.5
0.0032 0.5 0.5
0.0088 0.4477 0.5
0.0059 1 1
0.0059 1 1
0.0007 0.5 0.5
0.0062 0.6935 0.5
0.0081 1 0.5
0.0007 0.5 0.5
0.0067 0.5 0.5
0.0039 0.9485 0.5
0.0037 1 0.5
0.0063 1 0.5
0.0016 0.5 0.5
0.0042 0.5 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.2373
0.0033 1 0.5
0.0018 0.5 0.5
0.0007 0.5 0.5
0.0039 0.5 0.5
0.0066 0.3101 0.5
0.0003 0.5 0.5
0.0016 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_17231 (Giardia lamblia), Kinase, NEK
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