Detailed view for GL50803_7760

Basic information

TDR Targets ID: 813686
Giardia lamblia, Sentrin
Source Database / ID:  GiardiaDB  

pI: 4.9104 | Length (AA): 102 | MW (Da): 11476 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF11976   Ubiquitin-2 like Rad60 SUMO-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0016925   protein sumoylation  
GO:0005515   protein binding  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 102 1a5r (A) 1 98 40.00 0 1 1.4454 0
3 101 1wz0 (A) 2 100 34.00 0 1 1.47499 -0.79
25 100 5jp1 (B) 20 95 34.00 0 0.98 1.2975 -1.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127053)

Species Accession Gene Product
Arabidopsis thaliana AT5G55856   putative small ubiquitin-related modifier 8
Arabidopsis thaliana AT5G55160   small ubiquitin-related modifier 2
Arabidopsis thaliana AT4G26840   small ubiquitin-related modifier 1
Babesia bovis BBOV_IV003900   ubiquitin-like protein, putative
Brugia malayi Bm1_45210   Ubiquitin-like protein SMT3
Candida albicans CaO19.670   kinetochore protein
Candida albicans CaO19.8287   kinetochore protein
Caenorhabditis elegans CELE_K12C11.2   Protein SMO-1
Cryptosporidium hominis Chro.80490   ubiquitin-like protein
Cryptosporidium parvum cgd8_4260   conserved hypothetical protein
Dictyostelium discoideum DDB_G0286189   hypothetical protein
Drosophila melanogaster Dmel_CG4494   CG4494 gene product from transcript CG4494-RA
Drosophila melanogaster Dmel_CG43069   CG43069 gene product from transcript CG43069-RA
Echinococcus granulosus EgrG_001169800   Small ubiquitin modifier 2
Entamoeba histolytica EHI_170060   ubiquitin like protein
Echinococcus multilocularis EmuJ_001169800   Small ubiquitin modifier 2
Giardia lamblia GL50803_7760   Sentrin
Homo sapiens ENSG00000184900   small ubiquitin-like modifier 3
Homo sapiens ENSG00000116030   small ubiquitin-like modifier 1
Leishmania braziliensis LbrM.08.0500   small ubiquitin protein, putative
Leishmania donovani LdBPK_080480.1   small ubiquitin protein, putative
Leishmania infantum LinJ.08.0480   small ubiquitin protein, putative
Leishmania major LmjF.08.0470   small ubiquitin protein, putative
Leishmania mexicana LmxM.08.0470   small ubiquitin protein, putative
Loa Loa (eye worm) LOAG_01479   SMO-1 protein
Mus musculus 102640040   small ubiquitin-related modifier 2-like
Mus musculus ENSMUSG00000020738   SMT3 suppressor of mif two 3 homolog 2 (yeast)
Mus musculus ENSMUSG00000020265   SMT3 suppressor of mif two 3 homolog 3 (yeast)
Mus musculus 101056240   small ubiquitin-related modifier 2-like
Mus musculus 102642499   small ubiquitin-related modifier 2-like
Mus musculus ENSMUSG00000026021   SMT3 suppressor of mif two 3 homolog 1 (yeast)
Neospora caninum NCLIV_039480   hypothetical protein
Oryza sativa 4324359   Os01g0918200
Oryza sativa 4324360   Os01g0918300
Plasmodium berghei PBANKA_1105400   small ubiquitin-related modifier, putative
Plasmodium falciparum PF3D7_0505800   small ubiquitin-related modifier
Plasmodium knowlesi PKNH_1027800   small ubiquitin-related modifier, putative
Plasmodium vivax PVX_097850   small ubiquitin-related modifier, putative
Saccharomyces cerevisiae YDR510W   SUMO family protein SMT3
Schistosoma japonicum Sjp_0065660   Small ubiquitin-related modifier 2 precursor, putative
Schistosoma mansoni Smp_045510   ubiquitin-like protein sumo/smt3-related
Schmidtea mediterranea mk4.002820.01   Small ubiquitin modifier 1
Schmidtea mediterranea mk4.004710.01   Small ubiquitin modifier 1
Schmidtea mediterranea mk4.008996.01   Small ubiquitin modifier 1
Trypanosoma brucei gambiense Tbg972.5.4470   small ubiquitin protein, putative
Trypanosoma brucei Tb927.5.3210   small ubiquitin-related modifier
Trypanosoma cruzi TcCLB.511661.50   small ubiquitin protein, putative
Trypanosoma cruzi TcCLB.507809.70   small ubiquitin protein, putative
Toxoplasma gondii TGME49_266460   small ubiquitin family modifier, putative
Theileria parva TP01_1040   ubiquitin, putative
Trichomonas vaginalis TVAG_190260   conserved hypothetical protein

Essentiality

GL50803_7760 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.3210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.3210 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.3210 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.3210 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K12C11.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_K12C11.2 Caenorhabditis elegans slow growth wormbase
CELE_K12C11.2 Caenorhabditis elegans sterile wormbase
YDR510W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1105400 Plasmodium berghei Essential plasmo
TGME49_266460 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens small ubiquitin-like modifier 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0063 0.5 0.5
0.006 0.4905 0.4811
0.0037 1 0.5
0.006 0.4953 0.4811
0.0037 1 1
0.003 0.3235 1
0.0037 0.2677 1
0.0037 0.4374 1
0.0059 0.5714 1
0.0037 1 1
0.0059 0.5714 1
0.0051 0.8544 1
0.0057 0.5753 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier GL50803_7760 (Giardia lamblia), Sentrin
Title for this comment
Comment