Detailed view for GL50803_4653

Basic information

TDR Targets ID: 814754
Giardia lamblia, Serpin 1
Source Database / ID:  GiardiaDB  

pI: 6.3488 | Length (AA): 351 | MW (Da): 38786 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00079   Serpin (serine protease inhibitor)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005615   extracellular space  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 309 1hle (A) 26 351 28.00 0 1 1.12714 0.32
1 351 4au2 (A) 50 407 28.00 0.000000000039 1 1.2179 0.25
1 351 1k9o (I) 15 384 28.00 0 1 1.3068 -0.08
8 351 4p0f (A) 14 377 26.00 0 1 1.30086 -0.52
20 311 2h4p (A) 21 366 32.00 0 1 1.12681 0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126693)

Species Accession Gene Product
Arabidopsis thaliana AT1G62170   putative non-inhibitory serpin-Z5
Arabidopsis thaliana AT2G26390   serpin-Z3
Arabidopsis thaliana AT3G45220   serpin-Z4
Arabidopsis thaliana AT1G47710   serpin-ZX
Arabidopsis thaliana AT2G14540   serpin-2
Arabidopsis thaliana AT1G64030   serpin 3
Arabidopsis thaliana AT2G25240   serpin CCP3
Brugia malayi Bm1_25935   serpin
Brugia malayi Bm1_03995   serpin (BmSERPIN)
Brugia malayi Bm1_25940   serpin
Brugia malayi Bm1_04960   serpin (BmSERPIN)
Brugia malayi Bm1_25950   hypothetical protein
Brugia malayi Bm1_25930   hypothetical protein
Brugia malayi Bm1_25955   serpin
Brugia malayi Bm1_09430   BmSERPIN
Brugia malayi Bm1_25945   serpin
Brugia malayi Bm1_09775   serpin
Brugia malayi Bm1_18355   serpin
Caenorhabditis elegans CELE_F20D6.4   Protein SRP-7, isoform A
Caenorhabditis elegans CELE_C05E4.1   Protein SRP-2
Caenorhabditis elegans CELE_C03G6.19   Protein SRP-6
Drosophila melanogaster Dmel_CG33121   Serpin 28Db
Drosophila melanogaster Dmel_CG9460   Serpin 42De
Drosophila melanogaster Dmel_CG9334   Serpin 38F
Drosophila melanogaster Dmel_CG18525   Serpin 88Ea
Drosophila melanogaster Dmel_CG6717   Serpin 28B
Drosophila melanogaster Dmel_CG31902   Serpin 28Da
Drosophila melanogaster Dmel_CG8137   Serpin 28F
Drosophila melanogaster Dmel_CG6687   Serpin 88Eb
Drosophila melanogaster Dmel_CG9453   Serpin 42Da
Drosophila melanogaster Dmel_CG9456   Serpin 42Dd
Drosophila melanogaster Dmel_CG10913   Serpin 55B
Drosophila melanogaster Dmel_CG12172   Serpin 43Aa
Echinococcus granulosus EgrG_001193200   serine protease inhibitor
Echinococcus granulosus EgrG_002066800   serine protease inhibitor
Echinococcus granulosus EgrG_000824100   Estrogen regulated protein EP45
Echinococcus granulosus EgrG_001193100   serine protease inhibitor
Entamoeba histolytica EHI_119330   serine protease inhibitor, putative
Echinococcus multilocularis EmuJ_001193200   serine protease inhibitor
Echinococcus multilocularis EmuJ_001193100   serine protease inhibitor
Giardia lamblia GL50803_4653   Serpin 1
Homo sapiens ENSG00000163536   serpin peptidase inhibitor, clade I (neuroserpin), member 1
Homo sapiens ENSG00000057149   serpin peptidase inhibitor, clade B (ovalbumin), member 3
Homo sapiens ENSG00000021355   serpin peptidase inhibitor, clade B (ovalbumin), member 1
Homo sapiens ENSG00000124570   serpin peptidase inhibitor, clade B (ovalbumin), member 6
Homo sapiens ENSG00000206073   serpin peptidase inhibitor, clade B (ovalbumin), member 4
Loa Loa (eye worm) LOAG_12154   serpin
Loa Loa (eye worm) LOAG_15240   hypothetical protein
Loa Loa (eye worm) LOAG_13681   hypothetical protein
Loa Loa (eye worm) LOAG_11934   serpin
Loa Loa (eye worm) LOAG_15773   serpin
Loa Loa (eye worm) LOAG_12205   serpin
Mus musculus ENSMUSG00000073602   serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B
Mus musculus ENSMUSG00000073601   serine (or cysteine) peptidase inhibitor, clade B, member 3C
Mus musculus ENSMUSG00000051029   serine (or cysteine) peptidase inhibitor, clade B, member 1b
Mus musculus ENSMUSG00000044734   serine (or cysteine) peptidase inhibitor, clade B, member 1a
Mus musculus ENSMUSG00000042842   serine (or cysteine) peptidase inhibitor, clade B, member 6b
Mus musculus 666414   predicted gene 8089
Mus musculus 20713   serine (or cysteine) peptidase inhibitor, clade I, member 1
Mus musculus ENSMUSG00000044594   serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
Mus musculus 380839   serine (or cysteine) peptidase inhibitor, clade B, member 1c
Mus musculus ENSMUSG00000060147   serine (or cysteine) peptidase inhibitor, clade B, member 6a
Mus musculus ENSMUSG00000021404   serine (or cysteine) peptidase inhibitor, clade B, member 9c
Mus musculus ENSMUSG00000058017   serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D
Neospora caninum NCLIV_063150   Serpin peptidase inhibitor, clade B (Ovalbumin), member 1, like 3, related
Neospora caninum NCLIV_062190   GK22245, related
Oryza sativa 4326898   Os01g0765400
Oryza sativa 9269441   Os11g0290600
Oryza sativa 9270857   Os03g0610650
Oryza sativa 9268573   Os11g0230400
Oryza sativa 4333434   Os03g0610800
Oryza sativa 9267274   Os11g0580100
Oryza sativa 4324380   Os01g0267300
Onchocerca volvulus OVOC1850  
Onchocerca volvulus OVOC2080  
Onchocerca volvulus OVOC8529  
Onchocerca volvulus OVOC1983  
Schistosoma japonicum Sjp_0076600   Serpin B9, putative
Schistosoma japonicum Sjp_0218430   Serpin B9, putative
Schistosoma mansoni Smp_155560   serine protease inhibitors serpins
Schistosoma mansoni Smp_062120   serine protease inhibitors serpins
Schistosoma mansoni Smp_155550   serine protease inhibitors serpins
Schistosoma mansoni Smp_155530   serine protease inhibitors serpins
Schistosoma mansoni Smp_062080   serine protease inhibitors serpins
Schmidtea mediterranea mk4.001637.04   Minor histocompatibility protein HMSD variant form
Schmidtea mediterranea mk4.008095.01  
Schmidtea mediterranea mk4.008267.00   Minor histocompatibility protein HMSD variant form
Schmidtea mediterranea mk4.004115.01   Minor histocompatibility protein HMSD variant form
Schmidtea mediterranea mk4.009226.00  
Schmidtea mediterranea mk4.008630.01  
Schmidtea mediterranea mk4.013569.01  
Schmidtea mediterranea mk4.020562.00  
Schmidtea mediterranea mk4.032367.00  
Schmidtea mediterranea mk4.020562.01   Minor histocompatibility protein HMSD variant form
Toxoplasma gondii TGME49_217430   protease inhibitor PI1
Toxoplasma gondii TGME49_246130   serpin (serine proteinase inhibitor) superfamily protein

Essentiality

GL50803_4653 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_217430 Toxoplasma gondii Probably non-essential sidik
TGME49_246130 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0115 0.5 0.5
0.0025 0.5 0.5
0.0087 0.5 0.5
0.0122 0.4261 0.5
0.0018 1 0.5
0.0044 0.5 0.5
0.0044 0.5 0.5
0.002 0.4132 0.5
0.0011 0.5 0.5
0.0012 0.5 0.5
0.0017 0.3884 0.5
0.0011 0.5 0.5
0.0007 0.5 0.5
0.0036 1 0.5
0.0124 0.7236 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier GL50803_4653 (Giardia lamblia), Serpin 1
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