pI: 6.1647 |
Length (AA): 292 |
MW (Da): 31844 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
22 | 291 | 5dsv (C) | 1 | 237 | 33.00 | 0 | 1 | 1.17416 | -0.28 |
24 | 286 | 1ryp (C) | 2 | 239 | 31.00 | 0 | 1 | 1.16718 | -0.35 |
25 | 289 | 1ryp (G) | 4 | 238 | 36.00 | 0 | 1 | 1.28103 | -0.52 |
56 | 225 | 3unf (H) | 2 | 157 | 19.00 | 0.003 | 0.97 | 0.819692 | -0.69 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127755)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G27020 | 20S proteasome alpha subunit G1 |
Babesia bovis | BBOV_IV007800 | proteasome subunit alpha, putative |
Brugia malayi | Bm1_16260 | proteasome subunit alpha type 3 |
Candida albicans | CaO19.6582 | yeast proteasome subunit YC1 |
Candida albicans | CaO19_6582 | hypothetical protein |
Candida albicans | CaO19.13935 | yeast proteasome subunit YC1 |
Caenorhabditis elegans | CELE_ZK945.2 | Protein PAS-7 |
Cryptosporidium hominis | Chro.30260 | proteasome subunit alpha type 3 |
Cryptosporidium parvum | cgd3_2200 | proteasome subunit alpha type 3, NTN hydrolase fold |
Dictyostelium discoideum | DDB_G0267408 | 20S proteasome subunit C8 |
Drosophila melanogaster | Dmel_CG1519 | Proteasome alpha7 subunit |
Echinococcus granulosus | EgrG_000196100 | Proteasome subunit alpha beta |
Entamoeba histolytica | EHI_029210 | proteasome subunit alpha type 3, putative |
Entamoeba histolytica | EHI_098060 | proteasome subunit alpha type 3, putative |
Echinococcus multilocularis | EmuJ_000196100 | Proteasome, subunit alpha beta |
Giardia lamblia | GL50803_11486 | 20S proteasome alpha subunit 7 |
Homo sapiens | ENSG00000100567 | proteasome (prosome, macropain) subunit, alpha type, 3 |
Leishmania braziliensis | LbrM.27.0200 | proteasome alpha 7 subunit, putative |
Leishmania donovani | LdBPK_270190.1 | proteasome alpha 7 subunit, putative |
Leishmania infantum | LinJ.27.0190 | proteasome alpha 7 subunit, putative |
Leishmania major | LmjF.27.0190 | proteasome alpha 7 subunit, putative |
Leishmania mexicana | LmxM.27.0190 | proteasome alpha 7 subunit, putative |
Loa Loa (eye worm) | LOAG_06229 | proteasome subunit alpha type 3 |
Mus musculus | 19167 | proteasome (prosome, macropain) subunit, alpha type 3 |
Neospora caninum | NCLIV_059790 | proteasome subunit alpha type 3, putative |
Oryza sativa | 4339169 | Os05g0490800 |
Oryza sativa | 4327357 | Os01g0811100 |
Onchocerca volvulus | OVOC11117 | Notchless protein homolog |
Plasmodium berghei | PBANKA_0808200 | proteasome subunit alpha type-3, putative |
Plasmodium falciparum | PF3D7_0317000 | proteasome subunit alpha type-3, putative |
Plasmodium knowlesi | PKNH_0824800 | proteasome subunit alpha type-3, putative |
Plasmodium vivax | PVX_095380 | proteasome subunit alpha type-3, putative |
Plasmodium yoelii | PY00152 | Proteasome A-type and B-type, putative |
Saccharomyces cerevisiae | YOR362C | proteasome core particle subunit alpha 7 |
Schistosoma japonicum | Sjp_0217470 | ko:K02727 20S proteasome subunit alpha 7, putative |
Schistosoma mansoni | Smp_092280 | proteasome subunit alpha 3 (T01 family) |
Schmidtea mediterranea | mk4.000339.06 | Proteasome subunit alpha type-3 |
Trypanosoma brucei gambiense | Tbg972.3.400 | proteasome alpha 7 subunit |
Trypanosoma brucei | Tb927.3.780 | proteasome alpha 7 subunit |
Trypanosoma congolense | TcIL3000_3_150 | proteasome alpha 7 subunit, putative |
Trypanosoma congolense | TcIL3000_0_36040 | proteasome alpha 7 subunit |
Trypanosoma cruzi | TcCLB.507775.50 | proteasome alpha 7 subunit, putative |
Trypanosoma cruzi | TcCLB.511867.50 | proteasome alpha 7 subunit, putative |
Toxoplasma gondii | TGME49_216450 | peptidase, T1 family protein |
Theileria parva | TP03_0293 | proteasome subunit alpha type 3, putative |
Trichomonas vaginalis | TVAG_185200 | Family T1, proteasome alpha subunit, threonine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.780 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.780 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZK945.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK945.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_ZK945.2 | Caenorhabditis elegans | slow growth | wormbase |
YOR362C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0808200 | Plasmodium berghei | Essential | plasmo |
TGME49_216450 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, alpha type, 3 | Compounds | References |