Detailed view for GL50803_6731

Basic information

TDR Targets ID: 815140
Giardia lamblia, Kinase, NEK
Source Database / ID:  GiardiaDB  

pI: 7.3243 | Length (AA): 637 | MW (Da): 70421 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 323 3eqc (A) 43 367 27.00 0 1 0.596116 -0.13
21 385 4yhj (B) 157 526 22.00 0 1 0.696598 0.36
21 314 1phk (A) 30 284 28.00 0 0.96 0.504938 0.65
49 419 3mwu (A) 71 430 30.00 0 1 0.770818 0.54
51 311 2rku (A) 50 299 26.00 0 1 0.646333 -0.47
150 319 3bkb (A) 643 818 16.00 0 0.99 0.514076 -0.53
192 325 3aln (C) 231 375 39.00 0.019 0.81 0.00576107 1.18
300 544 4hbd (A) 590 828 21.00 0 1 0.597815 0.16
351 632 4rlv (A) 2126 2417 22.00 0 1 0.5883 0.14
386 503 4hrm (D) 47 158 44.00 0.0000048 1 0.554643 0.13
411 632 5le9 (A) 41 287 30.00 0 1 0.421109 0.07
430 632 5le6 (A) 19 287 31.00 0 1 0.329281 0.49
457 581 1n0r (A) 1 125 35.00 0 1 0.612832 -0.97
459 509 1ycs (B) 328 378 22.00 0 0.62 0.349263 -0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_202709)

Species Accession Gene Product
Giardia lamblia GL50803_6731   Kinase, NEK

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.3% 293 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 23.5% 306 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 25.6% 129 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 28.8% 299 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 27.1% 277 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 24.8% 298 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 27.9% 280 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0092 1 0.5
0.0063 0.7244 0
0.0032 0.5 0.5
0.0088 0.4477 0.5
0.0061 0.6883 1
0.0033 0.5 0.5
0.0026 0.5 0.5
0.0062 0.6935 0.5
0.0081 1 0.5
0.0007 0.5 0.5
0.0067 0.5 0.5
0.0059 1 1
0.0059 1 1
0.0007 0.5 0.5
0.0042 0.5 0.5
0.0016 0.5 0.5
0.0098 0.3242 0.2373
0.0012 0.5 0.5
0.0037 1 0.5
0.0039 0.9485 0.5
0.0063 1 0.5
0.0039 0.5 0.5
0.0066 0.3101 0.5
0.0003 0.5 0.5
0.0016 0.5 0.5
0.0033 1 0.5
0.0018 0.5 0.5
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0091 1 0.5
0.0059 1 1
0.0023 0.5 0.5
0.0004 0.5 0.5
0.0069 0.3067 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0008 0.5 0.5
0.0093 0.8828 0.5
0.0011 1 0.5
0.0027 1 0.5
0.0064 0.3377 0.5
0.0036 0.5 0.5
0.0012 0.5 0.5
0.0081 0.5 0.5
0.0022 0.5 0.5
0.0056 1 0.5
0.0029 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_6731 (Giardia lamblia), Kinase, NEK
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