Detailed view for LdBPK_312980.1

Basic information

TDR Targets ID: 816932
Leishmania donovani, aldehyde reductase, putative
Source Database / ID: 

pI: 7.45 | Length (AA): 286 | MW (Da): 31654 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00248   Aldo/keto reductase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 286 4wgh (A) 3 284 52.00 0 1 1.74921 -1.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126583)

Species Accession Gene Product
Arabidopsis thaliana AT2G37760   aldo-keto reductase family 4 member C8
Arabidopsis thaliana AT2G21250   putative NADPH dependent mannose 6-phosphate reductase
Arabidopsis thaliana AT2G21260   putative mannose-6P reductase
Arabidopsis thaliana AT2G37770   aldo-keto reductase family 4 member C9
Arabidopsis thaliana AT5G01670   putative aldose reductase
Arabidopsis thaliana AT2G37790   aldo-keto reductase family 4 member C10
Arabidopsis thaliana AT3G53880   aldo-keto reductase family 4 member C11
Brugia malayi Bm1_38415   oxidoreductase, aldo/keto reductase family protein
Brugia malayi Bm1_31490   oxidoreductase, aldo/keto reductase family protein
Brugia malayi Bm1_43535   oxidoreductase, aldo/keto reductase family protein
Brugia malayi Bm1_28070   oxidoreductase, aldo/keto reductase family protein
Candida albicans CaO19.6758   similar to mammalian aldo/keto reductases
Candida albicans CaO19.14108   see also nonallelic CaP19.2244
Candida albicans CaO19.14050   similar to mammalian aldo/keto reductases
Candida albicans CaO19.4317   Aldose reductase
Candida albicans CaO19.6816   see also nonallelic CaP19.2244
Candida albicans CaO19.6757   similar to mammalian aldo/keto reductases
Candida albicans CaO19.11792   Aldose reductase
Candida albicans CaO19.14049   similar to mammalian aldo/keto reductases
Caenorhabditis elegans CELE_F53F1.2   Protein F53F1.2
Caenorhabditis elegans CELE_C01G5.5   Protein C01G5.5
Caenorhabditis elegans CELE_ZC443.1   Protein ZC443.1
Caenorhabditis elegans CELE_Y39G8B.1   Protein Y39G8B.1, isoform A
Caenorhabditis elegans CELE_ZK1290.5   Protein ZK1290.5
Caenorhabditis elegans CELE_T08H10.1   Protein T08H10.1
Caenorhabditis elegans CELE_C07D8.6   Protein C07D8.6
Caenorhabditis elegans CELE_C35D10.6   Protein C35D10.6
Dictyostelium discoideum DDB_G0285053   aldo-keto reductase
Dictyostelium discoideum DDB_G0285025   aldo-keto reductase
Dictyostelium discoideum DDB_G0285023   aldo-keto reductase
Dictyostelium discoideum DDB_G0293850   aldehyde reductase
Dictyostelium discoideum DDB_G0285027   aldo-keto reductase
Dictyostelium discoideum DDB_G0268058   aldo-keto reductase
Drosophila melanogaster Dmel_CG6083   CG6083 gene product from transcript CG6083-RA
Drosophila melanogaster Dmel_CG6084   CG6084 gene product from transcript CG6084-RC
Drosophila melanogaster Dmel_CG10863   CG10863 gene product from transcript CG10863-RA
Drosophila melanogaster Dmel_CG9436   CG9436 gene product from transcript CG9436-RA
Drosophila melanogaster Dmel_CG10638   CG10638 gene product from transcript CG10638-RD
Drosophila melanogaster Dmel_CG12766   CG12766 gene product from transcript CG12766-RA
Escherichia coli b1781   aldo-keto reductase, methylglyoxal to acetol, NADPH-dependent
Escherichia coli b0207   2,5-diketo-D-gluconate reductase B
Escherichia coli b3012   2,5-diketo-D-gluconate reductase A
Echinococcus granulosus EgrG_000558000   aldo keto reductase family 1 member B4
Echinococcus granulosus EgrG_000156100   hypothetical protein
Echinococcus granulosus EgrG_000155400   aldo keto reductase family 1 member B4
Echinococcus granulosus EgrG_000156400   aldo keto reductase family 1 member B4
Echinococcus granulosus EgrG_000155600   aldo keto reductase family 1 member B4
Echinococcus granulosus EgrG_001163800   aldehyde reductase
Echinococcus granulosus EgrG_000523800   aldo keto reductase family 1 member B4
Echinococcus granulosus EgrG_000155500   aldo keto reductase
Echinococcus granulosus EgrG_000155900   aldo keto reductase family 1 member B4
Echinococcus granulosus EgrG_000156300   aldo keto reductase family 1 member B4
Echinococcus granulosus EgrG_000110500   aldo keto reductase
Echinococcus granulosus EgrG_000156200   aldo keto reductase
Echinococcus granulosus EgrG_000787800   aldo keto reductase family 1 member B4
Echinococcus granulosus EgrG_001163200   aldo keto reductase family 1 member B4
Entamoeba histolytica EHI_178670   aldose reductase, putative
Entamoeba histolytica EHI_039190   aldose reductase, putative
Entamoeba histolytica EHI_029620   aldose reductase, putative
Echinococcus multilocularis EmuJ_000155400   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_000155900   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_001163200   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_000787800   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_000156300   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_000558000   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_000156050   aldo keto reductase
Echinococcus multilocularis EmuJ_000155500   aldo keto reductase
Echinococcus multilocularis EmuJ_000156200   aldo keto reductase
Echinococcus multilocularis EmuJ_000110500   aldo keto reductase
Echinococcus multilocularis EmuJ_000156100   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_000156400   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_000523800   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_000155600   aldo keto reductase family 1, member B4
Echinococcus multilocularis EmuJ_001163800   aldehyde reductase
Echinococcus multilocularis EmuJ_000156000   aldo keto reductase family 1, member B4
Giardia lamblia GL50803_9008   Aldose reductase
Giardia lamblia GL50803_7260   Aldose reductase
Homo sapiens ENSG00000117448   aldo-keto reductase family 1, member A1 (aldehyde reductase)
Homo sapiens ENSG00000122787   aldo-keto reductase family 1, member D1
Homo sapiens ENSG00000198074   aldo-keto reductase family 1, member B10 (aldose reductase)
Homo sapiens ENSG00000085662   aldo-keto reductase family 1, member B1 (aldose reductase)
Leishmania braziliensis LbrM.27.2620   aldo-keto reductase-like protein
Leishmania braziliensis LbrM.32.0530   prostaglandin f synthase, putative
Leishmania braziliensis LbrM.31.3240   aldehyde reductase, putative,oxidoreductase, putative
Leishmania braziliensis LbrM.31.2410   prostaglandin f2-alpha synthase/D-arabinose dehydrogenase
Leishmania donovani LdBPK_272360.1   aldo-keto reductase-like protein
Leishmania donovani LdBPK_312980.1   aldehyde reductase, putative
Leishmania donovani LdBPK_320470.1   prostaglandin f synthase, putative
Leishmania donovani LdBPK_312210.1   prostaglandin f2-alpha synthase
Leishmania infantum LinJ.31.2210   prostaglandin f2-alpha synthase/D-arabinose dehydrogenase
Leishmania infantum LinJ.27.2360   aldo-keto reductase-like protein
Leishmania infantum LinJ.32.0470   prostaglandin f synthase, putative
Leishmania infantum LinJ.31.2980   aldehyde reductase, putative,oxidoreductase, putative
Leishmania major LmjF.31.2880   aldehyde reductase, putative,oxidoreductase, putative
Leishmania major LmjF.27.2410   aldo-keto reductase-like protein
Leishmania major LmjF.32.0460   prostaglandin f synthase, putative
Leishmania major LmjF.31.2150   prostaglandin f2-alpha synthase/D-arabinose dehydrogenase
Leishmania mexicana LmxM.30.2880   aldehyde reductase, putative,oxidoreductase, putative
Leishmania mexicana LmxM.31.0460   prostaglandin f synthase, putative
Leishmania mexicana LmxM.27.2410   aldo-keto reductase-like protein
Leishmania mexicana LmxM.30.2150   prostaglandin f2-alpha synthase
Loa Loa (eye worm) LOAG_07850   oxidoreductase
Loa Loa (eye worm) LOAG_14089   hypothetical protein
Loa Loa (eye worm) LOAG_00382   oxidoreductase
Loa Loa (eye worm) LOAG_12297   oxidoreductase
Loa Loa (eye worm) LOAG_07631   oxidoreductase
Loa Loa (eye worm) LOAG_07633   oxidoreductase
Mycobacterium leprae ML1669   PROBABLE OXIDOREDUCTASE
Mycobacterium leprae ML1668B   Conserved hypothetical protein
Mus musculus ENSMUSG00000029762   aldo-keto reductase family 1, member B8
Mus musculus ENSMUSG00000071551   aldo-keto reductase family 1, member C19
Mus musculus ENSMUSG00000038641   aldo-keto reductase family 1, member D1
Mus musculus ENSMUSG00000061758   aldo-keto reductase family 1, member B10 (aldose reductase)
Mus musculus ENSMUSG00000028692   aldo-keto reductase family 1, member A1 (aldehyde reductase)
Mus musculus ENSMUSG00000052131   aldo-keto reductase family 1, member B7
Mus musculus ENSMUSG00000021207   aldo-keto reductase family 1, member C21
Mus musculus ENSMUSG00000001642   aldo-keto reductase family 1, member B3 (aldose reductase)
Mycobacterium tuberculosis Rv2971   Probable oxidoreductase
Mycobacterium ulcerans MUL_1987   oxidoreductase
Neospora caninum NCLIV_033820   Oxidoreductase, aldo/keto reductase family, related
Oryza sativa 4335054   Os04g0167800
Oryza sativa 4335974   Os04g0447500
Oryza sativa 4328139   Os02g0123500
Oryza sativa 4327475   Os01g0847600
Oryza sativa 4335975   Os04g0447600
Oryza sativa 4338987   Os05g0456300
Oryza sativa 4339090   Os05g0474600
Oryza sativa 4335976   Os04g0447700
Oryza sativa 4327476   Os01g0847700
Oryza sativa 9271397   Os01g0847800
Onchocerca volvulus OVOC7491  
Onchocerca volvulus OVOC7490  
Onchocerca volvulus OVOC7492  
Onchocerca volvulus OVOC12715  
Onchocerca volvulus OVOC4708  
Onchocerca volvulus OVOC12059  
Saccharomyces cerevisiae YOR120W   glycerol 2-dehydrogenase (NADP(+)) GCY1
Saccharomyces cerevisiae YDR368W   trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1
Saccharomyces cerevisiae YJR096W   aldo-keto reductase superfamily protein
Saccharomyces cerevisiae YHR104W   trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))
Schistosoma japonicum Sjp_0217190   ko:K00011 aldehyde reductase [EC1.1.1.21], putative
Schistosoma japonicum Sjp_0128820   IPR001395,Aldo/keto reductase,domain-containing
Schistosoma mansoni Smp_053220.2   aldo-keto reductase
Schistosoma mansoni Smp_150700   pol-related
Schistosoma mansoni Smp_053220.1   aldo-keto reductase
Schmidtea mediterranea mk4.001259.08   Aldo-keto reductase family 1 member C-like protein 1
Schmidtea mediterranea mk4.000349.02   Aldo-keto reductase family 1 member C-like protein 1
Schmidtea mediterranea mk4.020436.00  
Schmidtea mediterranea mk4.015469.01  
Trypanosoma brucei gambiense Tbg972.11.5340   prostaglandin f synthase. putative
Trypanosoma brucei gambiense Tbg.972.2.3200   aldo-keto reductase, putative
Trypanosoma brucei Tb927.11.4700   prostaglandin f synthase
Trypanosoma brucei Tb927.2.5180   aldo-keto reductase, putative
Trypanosoma congolense TcIL3000.11.4810   prostaglandin f synthase, putative
Trypanosoma congolense TcIL3000_2_1280   aldo-keto reductase, putative
Trypanosoma cruzi TcCLB.511287.49   aldo-keto reductase
Trypanosoma cruzi TcCLB.511627.120   aldo/keto reductase, putative
Toxoplasma gondii TGME49_273920   aldose reductase, putative
Trichomonas vaginalis TVAG_080780   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_044820   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_506800   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_054660   aldo/keto reductase, putative
Trichomonas vaginalis TVAG_562150   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_370500   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_348390   dihydrodiol dehydrogenase, putative
Trichomonas vaginalis TVAG_175700   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_245190   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_495740   dihydrodiol dehydrogenase, putative
Trichomonas vaginalis TVAG_048690   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_312310   aldo/keto reductase, putative
Trichomonas vaginalis TVAG_602270   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_411870   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_007830   aldo/keto reductase, putative
Trichomonas vaginalis TVAG_465230   dihydrodiol dehydrogenase, putative
Trichomonas vaginalis TVAG_102160   aldo-keto reductase, putative
Trichomonas vaginalis TVAG_090550   aldo-keto reductase, putative

Essentiality

LdBPK_312980.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.2310 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.2310 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.2310 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.02.2310 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.5180 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.5180 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.5180 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.2.5180 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0207 Escherichia coli non-essential goodall
b1781 Escherichia coli non-essential goodall
b3012 Escherichia coli non-essential goodall
CELE_F53F1.2 Caenorhabditis elegans larval lethal wormbase
CELE_F53F1.2 Caenorhabditis elegans slow growth wormbase
CELE_C01G5.5 Caenorhabditis elegans embryonic lethal wormbase
TGME49_273920 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Aldehyde reductase Compounds References
Rattus norvegicus Aldose reductase Compounds References
Sus scrofa Aldose reductase Compounds References
Mus musculus aldo-keto reductase family 1, member C21 Compounds References
Rattus norvegicus Aldose reductase-related protein 1 Compounds References
Sus scrofa Aldehyde reductase Compounds References
Homo sapiens aldo-keto reductase family 1, member B10 (aldose reductase) Compounds References
Bos taurus Aldose reductase Compounds References
Homo sapiens aldo-keto reductase family 1, member A1 (aldehyde reductase) Compounds References
Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LdBPK_312980.1 (Leishmania donovani), aldehyde reductase, putative
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