Detailed view for LdBPK_201320.1

Basic information

TDR Targets ID: 818823
Leishmania donovani, calpain-like cysteine peptidase, putative

Source Database / ID: 

pI: 6.4824 | Length (AA): 151 | MW (Da): 17036 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF09149   Domain of unknown function (DUF1935)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 131 2fe0 (A) 1 131 41.00 0 1 1.43245 -0.7
11 126 1r75 (A) 13 132 28.00 0 0.95 1.14761 -0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_166720)

Species Accession Gene Product
Leishmania braziliensis LbrM.20.5500   calpain-like cysteine peptidase, putative,calpain-like cysteine peptidase, Clan CA, family C2
Leishmania donovani LdBPK_201320.1   calpain-like cysteine peptidase, putative
Leishmania infantum LinJ.20.1320   calpain-like cysteine peptidase, putative,calpain-like cysteine peptidase, Clan CA, family C2
Leishmania major LmjF.20.1280   small myristoylated protein 4, putative
Leishmania mexicana LmxM.20.1280   calpain-like cysteine peptidase, putative,calpain-like cysteine peptidase, Clan CA, family C2
Trypanosoma cruzi TcCLB.509001.40   calpain-like cysteine peptidase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major small myristoylated protein 4, putative Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major small myristoylated protein-1 131 aa 40.9% 132 aa Compounds References
Leishmania major small myristoylated protein-2 136 aa 39.3% 117 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LdBPK_201320.1 (Leishmania donovani), calpain-like cysteine peptidase, putative
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