Detailed view for LdBPK_300850.1

Basic information

TDR Targets ID: 820364
Leishmania donovani, rac serine-threonine kinase, putative
Source Database / ID: 

pI: 6.5626 | Length (AA): 510 | MW (Da): 57620 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00169   PH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 440 3v5w (A) 89 544 25.00 0 1 1.10935 0.13
1 89 2y7b (A) 986 1103 19.00 0 1 0.22911 -1.66
8 467 3nyn (A) 92 548 22.00 0 1 1.08456 0.41
14 378 5kcv (A) 22 427 38.00 0 1 0.917286 0.52
26 408 4wb7 (A) 28 405 35.00 0 1 1.12358 -0.02
47 510 3pvu (A) 132 625 22.00 0 1 1.0814 0.48
88 378 1vzo (A) 32 337 44.00 0 1 1.03319 -0.29
99 388 4nw6 (A) 61 359 43.00 0 1 1.10423 -0.65
104 361 2rku (A) 51 307 27.00 0 1 0.893482 -0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128147)

Species Accession Gene Product
Brugia malayi Bm1_24015   ribosomal protein S6 kinase alpha 3
Candida albicans CaO19.13654   Serine/threonine protein kinase
Candida albicans CaO19.6275   Serine/threonine protein kinase
Caenorhabditis elegans CELE_T01H8.1   Protein RSKN-1, isoform D
Dictyostelium discoideum DDB_G0277449   SGK family protein kinase
Drosophila melanogaster Dmel_CG17596   Ribosomal protein S6 kinase II
Echinococcus granulosus EgrG_000641400   ribosomal protein S6 kinase alpha 3
Echinococcus multilocularis EmuJ_000641400   ribosomal protein S6 kinase alpha 3
Giardia lamblia GL50803_11364   Kinase, AGC AKT
Homo sapiens ENSG00000072133   ribosomal protein S6 kinase, 90kDa, polypeptide 6
Homo sapiens ENSG00000117676   ribosomal protein S6 kinase, 90kDa, polypeptide 1
Homo sapiens ENSG00000071242   ribosomal protein S6 kinase, 90kDa, polypeptide 2
Homo sapiens ENSG00000177189   ribosomal protein S6 kinase, 90kDa, polypeptide 3
Leishmania braziliensis LbrM.30.0920   rac serine-threonine kinase, putative,protein kinase, putative
Leishmania donovani LdBPK_300850.1   rac serine-threonine kinase, putative
Leishmania infantum LinJ.30.0850   rac serine-threonine kinase, putative,protein kinase, putative
Leishmania major LmjF.30.0800   rac serine-threonine kinase, putative,protein kinase, putative
Leishmania mexicana LmxM.29.0800   rac serine-threonine kinase, putative,protein kinase, putative
Loa Loa (eye worm) LOAG_01357   AGC/RSK/RSK protein kinase
Mus musculus ENSMUSG00000023809   ribosomal protein S6 kinase, polypeptide 2
Mus musculus ENSMUSG00000025665   ribosomal protein S6 kinase polypeptide 6
Mus musculus ENSMUSG00000031309   ribosomal protein S6 kinase polypeptide 3
Mus musculus ENSMUSG00000003644   ribosomal protein S6 kinase polypeptide 1
Saccharomyces cerevisiae YBR028C   Ypk3p
Schistosoma japonicum Sjp_0216210   Ribosomal protein S6 kinase alpha-2, putative
Schistosoma japonicum Sjp_0106250   IPR000719,Protein kinase,domain-containing
Schistosoma japonicum Sjp_0129060   IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing
Schistosoma mansoni Smp_017900   serine/threonine protein kinase
Schmidtea mediterranea mk4.003305.00  
Schmidtea mediterranea mk4.001465.05  
Schmidtea mediterranea mk4.006921.00   Putative ribosomal protein S6 kinase alpha-1
Schmidtea mediterranea mk4.000379.06  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 6 Compounds References
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 Compounds References
Mus musculus ribosomal protein S6 kinase, polypeptide 2 Compounds References
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 Compounds References
Mus musculus ribosomal protein S6 kinase polypeptide 3 Compounds References
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 36.9% 309 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 37.6% 298 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 37.9% 298 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 24.8% 274 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.8% 295 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LdBPK_300850.1 (Leishmania donovani), rac serine-threonine kinase, putative
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