Detailed view for LdBPK_150180.1

Basic information

TDR Targets ID: 820862
Leishmania donovani, serine/threonine-protein kinase, putative
Source Database / ID: 

pI: 9.5861 | Length (AA): 745 | MW (Da): 80432 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 117 3aey (A) 136 242 36.00 0.27 0.04 0.230262 0.74
82 220 4dt5 (A) 11 138 32.00 0.013 0.52 0.308477 0.46
257 741 3pfq (A) 192 659 18.00 0 1 0.561407 1.38
339 676 4ylk (A) 136 481 45.00 0 1 1.07509 -1.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127901)

Species Accession Gene Product
Arabidopsis thaliana AT5G35980   YAK1-like protein 1
Brugia malayi Bm1_36970   Protein kinase domain containing protein
Caenorhabditis elegans CELE_T04C10.1   Protein MBK-1
Dictyostelium discoideum DDB_G0277485   DYRK family protein kinase
Dictyostelium discoideum DDB_G0283605   DYRK family protein kinase
Drosophila melanogaster Dmel_CG42273   minibrain
Echinococcus granulosus EgrG_000987500   dual specificity
Entamoeba histolytica EHI_023010   protein kinase, putative
Entamoeba histolytica EHI_141870   protein kinase domain containing protein
Entamoeba histolytica EHI_002350   hypothetical protein
Entamoeba histolytica EHI_158590   protein kinase, putative
Echinococcus multilocularis EmuJ_000987500   dual specificity
Homo sapiens ENSG00000105204   dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
Homo sapiens ENSG00000157540   dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Leishmania braziliensis LbrM.15.0170   serine/threonine-protein kinase, putative,protein kinase, putative
Leishmania donovani LdBPK_150180.1   serine/threonine-protein kinase, putative
Leishmania infantum LinJ.15.0180   serine/threonine-protein kinase, putative,protein kinase, putative
Leishmania major LmjF.15.0180   serine/threonine-protein kinase, putative,protein kinase, putative
Leishmania mexicana LmxM.15.0180   serine/threonine-protein kinase, putative,protein kinase, putative
Loa Loa (eye worm) LOAG_15734   hypothetical protein
Loa Loa (eye worm) LOAG_07332   hypothetical protein
Loa Loa (eye worm) LOAG_10900   CMGC/DYRK/DYRK1 protein kinase
Mus musculus ENSMUSG00000022897   dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Mus musculus ENSMUSG00000002409   dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
Oryza sativa 4330444   Os02g0702500
Oryza sativa 4336893   Os04g0602800
Saccharomyces cerevisiae YJL141C   Yak1p
Schistosoma japonicum Sjp_0130020   Serine/threonine-protein kinase minibrain, putative
Schistosoma japonicum Sjp_0211860   expressed protein
Schistosoma mansoni Smp_142610   serine/threonine protein kinase
Schmidtea mediterranea mk4.008193.01   Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1
Schmidtea mediterranea mk4.000667.02   Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1
Schmidtea mediterranea mk4.012025.00  
Schmidtea mediterranea mk4.017959.00   Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1
Trypanosoma brucei gambiense Tbg972.5.2270   serine/threonine-protein kinase, putative,protein kinase, putative
Trypanosoma brucei Tb927.5.1650   CMGC/DYRK protein kinase, putative
Trypanosoma congolense TcIL3000_0_20550   serine/threonine-protein kinase, putative
Trypanosoma congolense TcIL3000_5_1560   serine/threonine-protein kinase, putative
Trypanosoma cruzi TcCLB.506315.90   CMGC/DYRK protein kinase, putative
Trypanosoma cruzi TcCLB.506739.190   CMGC/DYRK protein kinase, putative

Essentiality

LdBPK_150180.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.1650 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.1650 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.1650 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.5.1650 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T04C10.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_T04C10.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a Compounds References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B Compounds References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Compounds References
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.6% 331 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 27.6% 333 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 28.4% 328 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 28.5% 333 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 31.6% 177 aa Compounds References
Patiria pectinifera Cdc2 300 aa 29.1% 326 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 28.7% 328 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LdBPK_150180.1 (Leishmania donovani), serine/threonine-protein kinase, putative
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