Detailed view for PBANKA_1018400

Basic information

TDR Targets ID: 824752
Plasmodium berghei, protein arginine N-methyltransferase 1, putative
Source Database / ID: 

pI: 6.442 | Length (AA): 393 | MW (Da): 46249 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13649   Methyltransferase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  
GO:0006479   protein amino acid methylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 368 3ua3 (A) 270 704 14.00 0 1 0.879042 1.1
73 388 1g6q (1) 21 340 49.00 0 1 1.44167 -0.63
78 392 5dst (A) 79 393 47.00 0 1 1.45013 -0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Ookinete, 4 hs Ring, 16 hs Trophozoite, Erthyrocytic stages. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Gametocyte, 22 hs Schizont, Female gametocyte, Male gametocyte. Otto TD Yeoh LM
Show/Hide expression data references
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.

Orthologs

Ortholog group members (OG5_127422)

Species Accession Gene Product
Arabidopsis thaliana AT2G19670   protein arginine N-methyltransferase 1
Arabidopsis thaliana AT4G29510   arginine methyltransferase 11
Babesia bovis BBOV_III010530   conserved hypothetical protein
Brugia malayi Bm1_25900   hypothetical protein
Candida albicans CaO19.10801   hnRNP methyltransferase.
Candida albicans CaO19.3291   hnRNP methyltransferase.
Caenorhabditis elegans CELE_Y113G7B.17   Protein PRMT-1
Cryptosporidium hominis Chro.80547   ARF GAP-like zinc finger-containing protein (ZIGA2)
Cryptosporidium parvum cgd8_4760   arginine n-methyltransferase
Dictyostelium discoideum DDB_G0291556   protein arginine methyltransferase
Drosophila melanogaster Dmel_CG6554   Arginine methyltransferase 1
Echinococcus granulosus EgrG_001035900   protein arginine N methyltransferase 8
Echinococcus granulosus EgrG_000911500   protein arginine methyltransferase
Entamoeba histolytica EHI_202470   arginine N-methyltransferase protein, putative
Entamoeba histolytica EHI_152460   hypothetical protein
Echinococcus multilocularis EmuJ_000911500   protein arginine methyltransferase
Echinococcus multilocularis EmuJ_001035900   protein arginine N methyltransferase 8
Homo sapiens ENSG00000111218   protein arginine methyltransferase 8
Leishmania braziliensis LbrM.20.6060   arginine N-methyltransferase-like protein
Leishmania donovani LdBPK_120850.1   arginine N-methyltransferase-like protein
Leishmania infantum LinJ.12.0850   arginine N-methyltransferase-like protein
Leishmania major LmjF.12.1270   arginine N-methyltransferase-like protein
Leishmania mexicana LmxM.12.1270   arginine N-methyltransferase-like protein
Loa Loa (eye worm) LOAG_04505   hypothetical protein
Mus musculus ENSMUSG00000030350   protein arginine N-methyltransferase 8
Mus musculus ENSMUSG00000052429   protein arginine N-methyltransferase 1
Neospora caninum NCLIV_061070   hypothetical protein
Oryza sativa 4346843   Os09g0359800
Plasmodium berghei PBANKA_1018400   protein arginine N-methyltransferase 1, putative
Plasmodium falciparum PF3D7_1426200   protein arginine N-methyltransferase 1
Plasmodium knowlesi PKNH_1332500   protein arginine N-methyltransferase 1, putative
Plasmodium vivax PVX_085215   protein arginine N-methyltransferase 1, putative
Plasmodium yoelii PY05140   probable protein arginine n-methyltransferase
Plasmodium yoelii PY00210   hypothetical protein
Saccharomyces cerevisiae YBR034C   protein-arginine omega-N methyltransferase HMT1
Schistosoma japonicum Sjp_0303070   ko:K00599 prmt1; protein arginine methyltransferase 1 [EC:2.1.1.-], putative
Schistosoma mansoni Smp_029240.1   protein arginine N-methyltransferase 1
Schistosoma mansoni Smp_029240.3   protein arginine N-methyltransferase 1
Schistosoma mansoni Smp_029240.2   protein arginine N-methyltransferase 1
Schmidtea mediterranea mk4.005105.01   Protein arginine methyltransferase 1-like protein
Schmidtea mediterranea mk4.001246.12   Protein arginine methyltransferase 1-like protein
Schmidtea mediterranea mk4.002331.04  
Schmidtea mediterranea mk4.019060.00  
Schmidtea mediterranea mk4.053376.00  
Trypanosoma brucei gambiense Tbg972.1.3210   arginine N-methyltransferase, putative
Trypanosoma brucei Tb927.1.4690   Protein arginine N-methyltransferase 1 catalytic subunit
Trypanosoma congolense TcIL3000_0_59430   arginine N-methyltransferase
Trypanosoma congolense TcIL3000_1_1890   arginine N-methyltransferase, putative
Trypanosoma cruzi TcCLB.506529.50   arginine N-methyltransferase, putative
Trypanosoma cruzi TcCLB.508593.110   arginine N-methyltransferase, putative
Toxoplasma gondii TGME49_219520   histone arginine methyltransferase PRMT1
Theileria parva TP02_0088   arginine N-methyltransferase, putative
Trichomonas vaginalis TVAG_199700   protein arginine N-methyltransferase, putative
Trichomonas vaginalis TVAG_028100   protein arginine N-methyltransferase, putative
Trichomonas vaginalis TVAG_433490   protein arginine N-methyltransferase, putative

Essentiality

PBANKA_1018400 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.4690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.4690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.4690 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.4690 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y113G7B.17 Caenorhabditis elegans slow growth wormbase
PBANKA_1018400 this record Plasmodium berghei Slow plasmo
TGME49_219520 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Emericella nidulans RmtA Compounds References
Homo sapiens protein arginine methyltransferase 8 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PBANKA_1018400 (Plasmodium berghei), protein arginine N-methyltransferase 1, putative
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