pI: 7.0601 |
Length (AA): 494 |
MW (Da): 55459 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 485 | 5hex (B) | 454 | 909 | 30.00 | 0 | 1 | 1.24877 | -0.38 |
32 | 492 | 5hex (B) | 20 | 468 | 34.00 | 0 | 1 | 1.2937 | -0.6 |
33 | 493 | 1bg3 (A) | 21 | 470 | 35.00 | 0 | 1 | 1.2698 | -0.22 |
34 | 487 | 4qs8 (A) | 41 | 492 | 31.00 | 0 | 1 | 1.28153 | -0.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Ookinete, 4 hs Ring, 16 hs Trophozoite, Erthyrocytic stages, Female gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Gametocyte, 22 hs Schizont, Male gametocyte. | Otto TD Yeoh LM |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_126743)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G29130 | hexokinase 1 |
Arabidopsis thaliana | AT1G47840 | hexokinase 3 |
Arabidopsis thaliana | AT2G19860 | hexokinase 2 |
Babesia bovis | BBOV_I000860 | hexokinase |
Brugia malayi | Bm1_41805 | Hexokinase family protein |
Brugia malayi | Bm1_36055 | hexokinase |
Candida albicans | CaO19.734 | one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) |
Candida albicans | CaO19.8353 | one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) |
Candida albicans | CaO19.7686 | one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) |
Candida albicans | CaO19.1408 | one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) |
Candida albicans | CaO19.8176 | similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose |
Candida albicans | CaO19.6116 | one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) |
Candida albicans | CaO19.13535 | one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) |
Candida albicans | CaO19.542 | similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose |
Candida albicans | CaO19.13 | one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W) |
Caenorhabditis elegans | CELE_F14B4.2 | Protein F14B4.2, isoform A |
Cryptosporidium hominis | Chro.60435 | hexokinase i |
Cryptosporidium parvum | cgd6_3800 | hexokinase |
Drosophila melanogaster | Dmel_CG8094 | Hexokinase C |
Drosophila melanogaster | Dmel_CG3001 | Hexokinase A |
Echinococcus granulosus | EgrG_000571200 | hexokinase type 2 |
Echinococcus granulosus | EgrG_000571500 | hexokinase |
Echinococcus granulosus | EgrG_000991700 | hexokinase |
Echinococcus granulosus | EgrG_000990400 | hexokinase |
Entamoeba histolytica | EHI_098290 | hexokinase 1 |
Entamoeba histolytica | EHI_098560 | hexokinase 2 |
Echinococcus multilocularis | EmuJ_000991700 | hexokinase |
Echinococcus multilocularis | EmuJ_000571500 | hexokinase |
Echinococcus multilocularis | EmuJ_000990400 | hexokinase |
Echinococcus multilocularis | EmuJ_000571200 | hexokinase type 2 |
Homo sapiens | ENSG00000106633 | glucokinase (hexokinase 4) |
Homo sapiens | ENSG00000160883 | hexokinase 3 (white cell) |
Homo sapiens | ENSG00000159399 | hexokinase 2 |
Homo sapiens | ENSG00000156510 | hexokinase domain containing 1 |
Homo sapiens | ENSG00000156515 | hexokinase 1 |
Leishmania braziliensis | LbrM.21.0310 | hexokinase, putative |
Leishmania donovani | LdBPK_210300.1 | hexokinase, putative |
Leishmania infantum | LinJ.21.0300 | hexokinase, putative |
Leishmania infantum | LinJ.21.0310 | hexokinase, putative |
Leishmania major | LmjF.21.0250 | hexokinase, putative |
Leishmania major | LmjF.21.0240 | hexokinase, putative |
Leishmania mexicana | LmxM.21.0240 | hexokinase, putative |
Leishmania mexicana | LmxM.21.0250 | hexokinase, putative |
Loa Loa (eye worm) | LOAG_01379 | hexokinase |
Loa Loa (eye worm) | LOAG_01380 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00481 | hexokinase |
Loa Loa (eye worm) | LOAG_05652 | hexokinase type II |
Mus musculus | ENSMUSG00000025877 | hexokinase 3 |
Mus musculus | ENSMUSG00000037012 | hexokinase 1 |
Mus musculus | ENSMUSG00000041798 | glucokinase |
Mus musculus | ENSMUSG00000000628 | hexokinase 2 |
Mus musculus | ENSMUSG00000020080 | hexokinase domain containing 1 |
Neospora caninum | NCLIV_039820 | cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related |
Oryza sativa | 4343113 | Os07g0446800 |
Oryza sativa | 4326776 | Os01g0190400 |
Oryza sativa | 4342654 | Os07g0197100 |
Oryza sativa | 4326547 | Os01g0742500 |
Oryza sativa | 4339361 | Os05g0522500 |
Oryza sativa | 4326516 | Os01g0940100 |
Onchocerca volvulus | OVOC1576 |
|
Onchocerca volvulus | OVOC558 |
|
Onchocerca volvulus | OVOC306 |
|
Plasmodium berghei | PBANKA_1122900 | hexokinase, putative |
Plasmodium falciparum | PF3D7_0624000 | hexokinase |
Plasmodium knowlesi | PKNH_1126200 | hexokinase, putative |
Plasmodium vivax | PVX_114315 | hexokinase, putative |
Plasmodium yoelii | PY02030 | hexokinase |
Saccharomyces cerevisiae | YCL040W | glucokinase |
Saccharomyces cerevisiae | YGL253W | hexokinase 2 |
Saccharomyces cerevisiae | YFR053C | hexokinase 1 |
Saccharomyces cerevisiae | YDR516C | putative glucokinase |
Schistosoma japonicum | Sjp_0302060 | ko:K00844 hexokinase [EC2.7.1.1], putative |
Schistosoma mansoni | Smp_043030 | hexokinase |
Schmidtea mediterranea | mk4.006200.01 | Hexokinase |
Schmidtea mediterranea | mk4.000389.10 | |
Schmidtea mediterranea | mk4.006200.00 | Hexokinase |
Schmidtea mediterranea | mk4.000389.09 | |
Trypanosoma brucei gambiense | Tbg972.10.2400 | hexokinase, putative |
Trypanosoma brucei gambiense | Tbg972.10.2420 | hexokinase, putative |
Trypanosoma brucei | Tb927.10.2010 | hexokinase |
Trypanosoma brucei | Tb11.v5.0732 | hexokinase, putative |
Trypanosoma brucei | Tb927.10.2020 | hexokinase |
Trypanosoma congolense | TcIL3000_0_38940 | hexokinase |
Trypanosoma cruzi | TcCLB.508951.20 | hexokinase, putative |
Trypanosoma cruzi | TcCLB.510121.20 | hexokinase, putative |
Toxoplasma gondii | TGME49_265450 | hexokinase |
Treponema pallidum | TP0505 | hexokinase (hxk) |
Theileria parva | TP01_0045 | hexokinase, putative |
Theileria parva | TP01_0043 | hexokinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.2010 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2010 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2010 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.2010 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F14B4.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F14B4.2 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1122900 this record | Plasmodium berghei | Essential | plasmo |
TGME49_265450 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Hexokinase type IV | Compounds | References |
Homo sapiens | hexokinase 2 | Compounds | References |
Trypanosoma cruzi | hexokinase, putative | Compounds | References |
Homo sapiens | hexokinase domain containing 1 | Compounds | References |
Homo sapiens | hexokinase 1 | Compounds | References |
Mus musculus | glucokinase | Compounds | References |
Homo sapiens | glucokinase (hexokinase 4) | Compounds | References |
Trypanosoma brucei | hexokinase | Compounds | References |
Trypanosoma cruzi | hexokinase, putative | Compounds | References |