pI: 9.7252 |
Length (AA): 323 |
MW (Da): 37673 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 295 | 5fqd (C) | 10 | 303 | 67.00 | 0 | 1 | 1.67362 | -1.02 |
2 | 295 | 3sv0 (A) | 2 | 295 | 69.00 | 0 | 1 | 1.68962 | -0.98 |
5 | 322 | 4xhl (A) | 5 | 366 | 56.00 | 0 | 1 | 1.53192 | -0.46 |
5 | 293 | 1csn (A) | 8 | 298 | 53.00 | 0 | 1 | 1.49614 | -0.8 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Gametocyte, Ookinete, 4 hs Ring, 16 hs Trophozoite, 22 hs Schizont, Erthyrocytic stages, Female gametocyte, Male gametocyte. | Otto TD Yeoh LM |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Ortholog group members (OG5_126780)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G03930 | dual specificity kinase 1 |
Arabidopsis thaliana | AT4G26100 | casein kinase 1 |
Arabidopsis thaliana | AT5G43320 | casein kinase I-like 8 |
Arabidopsis thaliana | AT4G14340 | casein kinase I |
Arabidopsis thaliana | AT5G44100 | casein kinase I-like 7 |
Arabidopsis thaliana | AT2G19470 | casein kinase I-like 5 |
Arabidopsis thaliana | AT3G23340 | casein kinase I-like 10 |
Arabidopsis thaliana | AT1G72710 | casein kinase 1-like protein 2 |
Arabidopsis thaliana | AT5G57015 | casein kinase I-like 12 |
Arabidopsis thaliana | AT4G28540 | casein kinase I-like 6 |
Arabidopsis thaliana | AT1G04440 | casein kinase like 13 |
Babesia bovis | BBOV_III002900 | casein kinase I, putative |
Brugia malayi | Bm1_37175 | casein kinase 1, delta |
Brugia malayi | Bm1_45085 | casein kinase I |
Candida albicans | CaO19.3476 | Casein kinase I: DNA repair, meiosis |
Candida albicans | CaO19.10980 | Casein kinase I: DNA repair, meiosis |
Caenorhabditis elegans | CELE_F46F2.2 | Protein KIN-20, isoform F |
Caenorhabditis elegans | CELE_C03C10.1 | Protein KIN-19 |
Cryptosporidium hominis | Chro.30215 | casein kinase i |
Cryptosporidium parvum | cgd3_1810 | casein kinase I |
Dictyostelium discoideum | DDB_G0273737 | casein kinase I |
Dictyostelium discoideum | DDB_G0273059 | casein kinase I |
Drosophila melanogaster | Dmel_CG2028 | Casein kinase Ialpha |
Drosophila melanogaster | Dmel_CG2048 | discs overgrown |
Echinococcus granulosus | EgrG_000815700 | casein kinase I alpha |
Echinococcus granulosus | EgrG_000689400 | casein kinase i |
Echinococcus granulosus | EgrG_000089800 | casein kinase I delta |
Echinococcus granulosus | EgrG_000686600 | casein kinase I delta |
Echinococcus granulosus | EgrG_000637900 | casein kinase I alpha |
Echinococcus granulosus | EgrG_000820700 | casein kinase I alpha |
Entamoeba histolytica | EHI_151950 | casein kinase, putative |
Entamoeba histolytica | EHI_156390 | casein kinase 1, putative |
Echinococcus multilocularis | EmuJ_000820700 | casein kinase I alpha |
Echinococcus multilocularis | EmuJ_000815700 | casein kinase I alpha |
Echinococcus multilocularis | EmuJ_000637900 | casein kinase I alpha |
Echinococcus multilocularis | EmuJ_000089800 | casein kinase I delta |
Echinococcus multilocularis | EmuJ_000689400 | casein kinase i |
Echinococcus multilocularis | EmuJ_000686600 | casein kinase I delta |
Giardia lamblia | GL50803_7537 | Kinase, CK1 Casein kinase |
Homo sapiens | 102800317 | LOC400927-CSNK1E readthrough |
Homo sapiens | ENSG00000141551 | casein kinase 1, delta |
Homo sapiens | ENSG00000213923 | casein kinase 1, epsilon |
Homo sapiens | ENSG00000180138 | casein kinase 1, alpha 1-like |
Homo sapiens | ENSG00000113712 | casein kinase 1, alpha 1 |
Leishmania braziliensis | LbrM.34.1000 | casein kinase, putative |
Leishmania donovani | LdBPK_351030.1 | casein kinase, putative |
Leishmania infantum | LinJ.35.1030 | casein kinase, putative |
Leishmania major | LmjF.35.1010 | casein kinase, putative |
Leishmania mexicana | LmxM.34.1010 | casein kinase, putative |
Loa Loa (eye worm) | LOAG_01275 | CK1/CK1/CK1-A protein kinase |
Loa Loa (eye worm) | LOAG_01274 | CK1/CK1/CK1-A protein kinase |
Loa Loa (eye worm) | LOAG_05803 | CK1/CK1/CK1-D protein kinase |
Mus musculus | ENSMUSG00000024576 | casein kinase 1, alpha 1 |
Mus musculus | ENSMUSG00000022433 | casein kinase 1, epsilon |
Mus musculus | ENSMUSG00000025162 | casein kinase 1, delta |
Neospora caninum | NCLIV_016840 | AFL091Wp, related |
Oryza sativa | 4331096 | Os02g0810400 |
Oryza sativa | 4336396 | Os04g0514800 |
Oryza sativa | 4348890 | Os10g0476300 |
Oryza sativa | 4330018 | Os02g0622100 |
Oryza sativa | 4339803 | Os05g0593800 |
Oryza sativa | 4326345 | Os01g0570500 |
Oryza sativa | 9267711 | Os01g0708400 |
Onchocerca volvulus | OVOC6677 |
|
Onchocerca volvulus | OVOC8481 |
|
Plasmodium berghei | PBANKA_0912100 | casein kinase 1, putative |
Plasmodium falciparum | PF3D7_1136500 | casein kinase 1 |
Plasmodium knowlesi | PKNH_0934700 | casein kinase 1, putative |
Plasmodium vivax | PVX_092440 | casein kinase 1, putative |
Plasmodium yoelii | PY06011 | casein kinase i |
Saccharomyces cerevisiae | YPL204W | Hrr25p |
Schistosoma japonicum | Sjp_0055230 | ko:K02218 casein kinase 1, putative |
Schistosoma japonicum | Sjp_0105060 | Casein kinase I isoform delta, putative |
Schistosoma japonicum | Sjp_0304020 | ko:K08959 casein kinase 1, delta, putative |
Schistosoma mansoni | Smp_169950 | serine/threonine protein kinase |
Schistosoma mansoni | Smp_067810 | protein kinase |
Schmidtea mediterranea | mk4.001951.08 | Casein kinase I |
Schmidtea mediterranea | mk4.001458.07 | |
Schmidtea mediterranea | mk4.019126.02 | Casein kinase I |
Schmidtea mediterranea | mk4.002059.06 | |
Schmidtea mediterranea | mk4.001279.00 | |
Schmidtea mediterranea | mk4.004518.01 | Casein kinase I |
Schmidtea mediterranea | mk4.000674.07 | Casein kinase I |
Schmidtea mediterranea | mk4.027310.00 | Casein kinase I |
Schmidtea mediterranea | mk4.000425.06 | |
Schmidtea mediterranea | mk4.002059.07 | Casein kinase I |
Schmidtea mediterranea | mk4.000988.05 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.000532.10 | |
Schmidtea mediterranea | mk4.000988.06 | Serine/threonine kinase |
Trypanosoma brucei gambiense | Tbg972.5.1140 | casein kinase, putative |
Trypanosoma brucei | Tb927.5.800 | casein kinase I, isoform 2 |
Trypanosoma congolense | TcIL3000_0_32110 | casein kinase I, isoform 2 |
Trypanosoma congolense | TcIL3000_5_480 | casein kinase, putative |
Trypanosoma cruzi | TcCLB.507305.20 | casein kinase, putative |
Trypanosoma cruzi | TcCLB.508541.230 | casein kinase, putative |
Trypanosoma cruzi | TcCLB.507305.30 | casein kinase, putative |
Trypanosoma cruzi | TcCLB.504929.15 | casein kinase, delta isoform, putative |
Trypanosoma cruzi | TcCLB.507541.40 | casein kinase, putative |
Trypanosoma cruzi | TcCLB.508541.240 | casein kinase, putative |
Trypanosoma cruzi | TcCLB.504929.10 | casein kinase, delta isoform, putative |
Toxoplasma gondii | TGME49_240640 | casein kinase I |
Theileria parva | TP03_0315 | casein kinase I, putative |
Trichomonas vaginalis | TVAG_388850 | CK1 family protein kinase |
Trichomonas vaginalis | TVAG_218210 | CK1 family protein kinase |
Trichomonas vaginalis | TVAG_252620 | CK1 family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C03C10.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C03C10.1 | Caenorhabditis elegans | sterile | wormbase |
CELE_F46F2.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F46F2.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F46F2.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F46F2.2 | Caenorhabditis elegans | sterile | wormbase |
YPL204W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0912100 this record | Plasmodium berghei | Essential | plasmo |
TGME49_240640 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Casein kinase I delta | Compounds | References |
Homo sapiens | casein kinase 1, alpha 1 | Compounds | References |
Sus scrofa | Casein kinase 1, delta tv1 | Compounds | References |
Sus scrofa | Casein kinase I isoform alpha | Compounds | References |
Bos taurus | Casein kinase I isoform alpha | Compounds | References |
Homo sapiens | casein kinase 1, epsilon | Compounds | References |
Homo sapiens | casein kinase 1, alpha 1-like | Compounds | References |
Homo sapiens | casein kinase 1, delta | Compounds | References |