Detailed view for PBANKA_1460000

Basic information

TDR Targets ID: 828646
Plasmodium berghei, rac-beta serine/threonine protein kinase, putative
Source Database / ID: 

pI: 10.4148 | Length (AA): 717 | MW (Da): 84276 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00433   Protein kinase C terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
181 706 3nyn (A) 7 515 20.00 0 1 0.710812 0.48
376 671 2r5t (A) 83 378 51.00 0 1 1.02393 -0.58
384 715 4gv1 (A) 143 477 47.00 0 1 1.09014 -0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Ookinete. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Gametocyte, 4 hs Ring, 16 hs Trophozoite, 22 hs Schizont, Erthyrocytic stages, Female gametocyte, Male gametocyte. Otto TD Yeoh LM
Show/Hide expression data references
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.

Orthologs

Ortholog group members (OG5_126635)

Species Accession Gene Product
Arabidopsis thaliana AT3G08730   protein-serine kinase 1
Arabidopsis thaliana AT3G08720   serine/threonine protein kinase 2
Brugia malayi Bm1_51830   Protein kinase domain containing protein
Brugia malayi Bm1_44635   p70 ribosomal S6 kinase beta
Candida albicans CaO19.8029   protein kinase
Candida albicans CaO19.399   likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)
Caenorhabditis elegans CELE_C12D8.10   Protein AKT-1, isoform C
Caenorhabditis elegans CELE_F28H6.1   Protein AKT-2, isoform B
Caenorhabditis elegans CELE_Y47D3A.16   Protein RSKS-1
Caenorhabditis elegans CELE_W10G6.2   Protein SGK-1, isoform A
Dictyostelium discoideum DDB_G0286125   protein kinase 3
Dictyostelium discoideum DDB_G0268620   AKT family protein kinase
Dictyostelium discoideum DDB_G0290157   SGK family protein kinase
Drosophila melanogaster Dmel_CG4006   CG4006 gene product from transcript CG4006-RE
Drosophila melanogaster Dmel_CG10539   RPS6-p70-protein kinase
Echinococcus granulosus EgrG_000979200   serine/threonine protein kinase
Echinococcus granulosus EgrG_001199300   calcium:calmodulin dependent protein kinase
Echinococcus granulosus EgrG_000971900   nervana 2
Echinococcus granulosus EgrG_000979300   Glutaredoxin protein 5
Echinococcus granulosus EgrG_000971700   sodium:potassium dependent atpase beta subunit
Echinococcus granulosus EgrG_001123600   nervana 2
Echinococcus granulosus EgrG_000836700   serine threonine protein kinase nrc
Entamoeba histolytica EHI_137850   protein kinase, putative
Entamoeba histolytica EHI_004790   protein kinase, putative
Entamoeba histolytica EHI_044470   protein kinase, putative
Entamoeba histolytica EHI_138540   PH domain containing protein kinase, putative
Entamoeba histolytica EHI_053130   protein kinase 2, putative
Entamoeba histolytica EHI_097620   PH domain containing protein kinase, putative
Echinococcus multilocularis EmuJ_000979200   rac serine:threonine kinase
Echinococcus multilocularis EmuJ_000971700   nervana 2
Echinococcus multilocularis EmuJ_000979300   Glutaredoxin protein 5
Echinococcus multilocularis EmuJ_000836700   serine threonine protein kinase nrc serine threonine protein kinase gad
Echinococcus multilocularis EmuJ_001123600   nervana 2
Echinococcus multilocularis EmuJ_000971900   sodium:potassium dependent atpase beta subunit
Giardia lamblia GL50803_86444   Kinase, AGC PKA
Homo sapiens ENSG00000105221   v-akt murine thymoma viral oncogene homolog 2
Homo sapiens ENSG00000104205   serum/glucocorticoid regulated kinase family, member 3
Homo sapiens ENSG00000118515   serum/glucocorticoid regulated kinase 1
Homo sapiens ENSG00000101049   serum/glucocorticoid regulated kinase 2
Homo sapiens ENSG00000175634   ribosomal protein S6 kinase, 70kDa, polypeptide 2
Homo sapiens 100533105   C8orf44-SGK3 readthrough
Homo sapiens ENSG00000117020   v-akt murine thymoma viral oncogene homolog 3
Homo sapiens ENSG00000142208   v-akt murine thymoma viral oncogene homolog 1
Homo sapiens ENSG00000108443   ribosomal protein S6 kinase, 70kDa, polypeptide 1
Loa Loa (eye worm) LOAG_00559   AGC/RSK/P70 protein kinase
Loa Loa (eye worm) LOAG_08621   AGC/AKT protein kinase
Mus musculus ensembl-mmu:ENSMUSG00000020516   ribosomal protein S6 kinase, polypeptide 1
Mus musculus ENSMUSG00000019699   thymoma viral proto-oncogene 3
Mus musculus ENSMUSG00000017868   serum/glucocorticoid regulated kinase 2
Mus musculus ENSMUSG00000001729   thymoma viral proto-oncogene 1
Mus musculus ENSMUSG00000019970   serum/glucocorticoid regulated kinase 1
Mus musculus ENSMUSG00000004056   thymoma viral proto-oncogene 2
Mus musculus 170755   serum/glucocorticoid regulated kinase 3
Mus musculus ENSMUSG00000024830   ribosomal protein S6 kinase, polypeptide 2
Neospora caninum NCLIV_038640   Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related
Oryza sativa 4332748   Os03g0334000
Oryza sativa 4344299   Os07g0680900
Plasmodium berghei PBANKA_1460000   rac-beta serine/threonine protein kinase, putative
Plasmodium falciparum PF3D7_1246900   RAC-beta serine/threonine protein kinase
Plasmodium knowlesi PKNH_1466600   RAC-beta serine/threonine protein kinase
Plasmodium vivax PVX_101240   rac-beta serine/threonine protein kinase, putative
Plasmodium yoelii PY00403   kinase Akt/PKB-related
Saccharomyces cerevisiae YKL126W   Ypk1p
Saccharomyces cerevisiae YMR104C   Ypk2p
Schistosoma japonicum Sjp_0112070   ko:K04456 RAC serine/threonine-protein kinase, putative
Schistosoma japonicum Sjp_0306150   ko:K07390 monothiol glutaredoxin, putative
Schistosoma japonicum Sjp_0062340   ko:K08792 serum/glucocorticoid regulated kinase, putative
Schistosoma japonicum Sjp_0047140   Sodium/potassium-transporting ATPase subunit beta-1, putative
Schistosoma japonicum Sjp_0118010   RAC serine/threonine-protein kinase, putative
Schistosoma mansoni Smp_073930.1   serine/threonine-protein kinase
Schistosoma mansoni Smp_073930.2   serine/threonine-protein kinase
Schmidtea mediterranea mk4.002029.04  
Schmidtea mediterranea mk4.020817.00   Putative sodium/potassium-dependent atpase beta subunit
Schmidtea mediterranea mk4.030501.01   S6K1-like protein
Schmidtea mediterranea mk4.001401.07  
Schmidtea mediterranea mk4.010874.00  
Schmidtea mediterranea mk4.013008.01   Putative sodium/potassium-dependent atpase beta subunit
Schmidtea mediterranea mk4.032603.00  
Schmidtea mediterranea mk4.006881.00   Putative sodium/potassium-dependent atpase beta subunit
Schmidtea mediterranea mk4.000477.09  
Schmidtea mediterranea mk4.002017.07   Serine/threonine-protein kinase N
Schmidtea mediterranea mk4.000534.01  
Schmidtea mediterranea mk4.020536.00  
Schmidtea mediterranea mk4.009141.00   Putative sodium/potassium-dependent atpase beta subunit
Trypanosoma brucei gambiense Tbg972.6.2030   rac serine-threonine kinase, putative,protein kinase, putative
Trypanosoma brucei Tb927.6.2250   rac serine-threonine kinase, putative
Trypanosoma congolense TcIL3000_0_37860   rac serine-threonine kinase, putative
Trypanosoma cruzi TcCLB.508965.60   rac serine-threonine kinase, putative
Trypanosoma cruzi TcCLB.509007.60   rac serine-threonine kinase, putative
Trypanosoma cruzi TcCLB.509047.110   Protein kinase B
Toxoplasma gondii TGME49_267540   AGC kinase
Trichomonas vaginalis TVAG_447920   AGC family protein kinase
Trichomonas vaginalis TVAG_430560   AGC family protein kinase
Trichomonas vaginalis TVAG_316050   AGC family protein kinase
Trichomonas vaginalis TVAG_047250   AGC family protein kinase
Trichomonas vaginalis TVAG_195270   AGC family protein kinase
Trichomonas vaginalis TVAG_267830   AGC family protein kinase
Trichomonas vaginalis TVAG_324020   AGC family protein kinase

Essentiality

PBANKA_1460000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.2250 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.2250 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.2250 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.6.2250 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C12D8.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_W10G6.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y47D3A.16 Caenorhabditis elegans larval arrest wormbase
CELE_Y47D3A.16 Caenorhabditis elegans larval lethal wormbase
TGME49_267540 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus thymoma viral proto-oncogene 1 Compounds References
Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 Compounds References
Mus musculus serum/glucocorticoid regulated kinase 1 Compounds References
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Compounds References
Homo sapiens serum/glucocorticoid regulated kinase 2 Compounds References
Homo sapiens v-akt murine thymoma viral oncogene homolog 3 Compounds References
Homo sapiens v-akt murine thymoma viral oncogene homolog 2 Compounds References
Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 2 Compounds References
Plasmodium falciparum RAC-beta serine/threonine protein kinase Compounds References
Homo sapiens serum/glucocorticoid regulated kinase 1 Compounds References
Homo sapiens serum/glucocorticoid regulated kinase family, member 3 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.1% 295 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 22.9% 306 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 24.0% 317 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 40.8% 321 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 27.0% 263 aa Compounds References
Patiria pectinifera Cdc2 300 aa 23.5% 311 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 43.5% 292 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 25.2% 286 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 26.8% 313 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 23.6% 331 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 39.9% 321 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PBANKA_1460000 (Plasmodium berghei), rac-beta serine/threonine protein kinase, putative
Title for this comment
Comment