Detailed view for PBANKA_1133100

Basic information

TDR Targets ID: 828729
Plasmodium berghei, serine/threonine protein kinase, putative
Source Database / ID: 

pI: 8.7751 | Length (AA): 3675 | MW (Da): 426511 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
917 1557 3pvu (A) 32 668 18.00 0 1 0.0230218 0.98
1084 1340 2rku (A) 53 309 27.00 0 1 0.432632 -0.47
1132 1332 3kul (A) 684 890 28.00 0.0023 0.88 0.329294 -0.62
1139 1283 2xk7 (A) 62 216 41.00 0.0015 0.78 0.169056 0.63
1881 2614 5vw1 (A) 585 1319 20.00 0.22 0.98 0.159428 1.54
2087 2504 4fp7 (B) 44 475 12.00 0 0.57 -0.0676585 0.59
2211 2374 5gyj (A) 29 201 31.00 0.54 0.47 0.111326 0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male gametocyte. Yeoh LM
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Gametocyte, 22 hs Schizont. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Ookinete, 4 hs Ring, 16 hs Trophozoite, Erthyrocytic stages, Female gametocyte. Otto TD Yeoh LM
Show/Hide expression data references
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.

Orthologs

Ortholog group members (OG5_160431)

Species Accession Gene Product
Cryptosporidium hominis Chro.60086   OSK4
Plasmodium berghei PBANKA_1133100   serine/threonine protein kinase, putative
Plasmodium falciparum PF3D7_1356800   serine/threonine protein kinase, putative
Plasmodium knowlesi PKNH_1114700   serine/threonine protein kinase, putative
Plasmodium vivax PVX_114820   protein kinase domain containing protein
Plasmodium yoelii PY02340   chloroquine resistance marker protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus MAP kinase p38 alpha 360 aa 25.7% 303 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 29.4% 265 aa Compounds References
Patiria pectinifera Cdc2 300 aa 27.1% 291 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PBANKA_1133100 (Plasmodium berghei), serine/threonine protein kinase, putative
Title for this comment
Comment