Detailed view for PBANKA_1229800

Basic information

TDR Targets ID: 829076
Plasmodium berghei, enoyl-acyl carrier reductase
Source Database / ID: 

pI: 9.5521 | Length (AA): 396 | MW (Da): 44777 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13561   Enoyl-(Acyl carrier protein) reductase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
80 389 3f4b (A) 80 389 99.99 0 1 1.89063 -1.05
328 384 3grk (A) 195 257 28.00 0 0.02 0.263439 1.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Gametocyte, Ookinete, 22 hs Schizont, Male gametocyte. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile 4 hs Ring. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile 16 hs Trophozoite, Erthyrocytic stages, Female gametocyte. Otto TD Yeoh LM
Show/Hide expression data references
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.

Orthologs

Ortholog group members (OG5_130466)

Species Accession Gene Product
Arabidopsis thaliana AT2G05990   enoyl-[acyl-carrier-protein] reductase [NADH]
Chlamydia trachomatis CT_104   enoyl-acyl-carrier protein reductase
Escherichia coli b1288   enoyl-[acyl-carrier-protein] reductase, NADH-dependent
Mycobacterium leprae ML1806c   NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)
Mycobacterium tuberculosis Rv1484   NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)
Mycobacterium ulcerans MUL_1492   enoyl-(acyl carrier protein) reductase
Neospora caninum NCLIV_066970   enoyl-acyl carrier reductase, putative
Oryza sativa 4346596   Os09g0277800
Oryza sativa 4345286   Os08g0327400
Plasmodium berghei PBANKA_1229800   enoyl-acyl carrier reductase
Plasmodium falciparum PF3D7_0615100   enoyl-acyl carrier reductase
Plasmodium knowlesi PKNH_1134900   enoyl-acyl carrier reductase, putative
Plasmodium vivax PVX_113890   enoyl-acyl carrier protein reductase
Plasmodium yoelii PY03846   enoyl-acyl carrier reductase
Toxoplasma gondii TGME49_251930   enoyl-acyl carrier reductase ENR
Trichomonas vaginalis TVAG_214820   hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0470   enoyl-ACP reductase

Essentiality

PBANKA_1229800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1508 Mycobacterium tuberculosis non-essential nmpdr
b1288 Escherichia coli essential goodall
TGME49_251930 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum enoyl-acyl carrier reductase Compounds References
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Compounds References
Staphylococcus aureus subsp. aureus MRSA252 Enoyl-[acyl-carrier-protein] reductase Compounds References
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Compounds References
Staphylococcus aureus (strain NCTC 8325) Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI Compounds References
Escherichia coli enoyl-[acyl-carrier-protein] reductase, NADH-dependent Compounds References
Bacillus subtilis (strain 168) Enoyl-[acyl-carrier-protein] reductase [NADH] Compounds References
Staphylococcus aureus Enoyl-ACP reductase Compounds References
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) Enoyl-[acyl-carrier-protein] reductase [NADH] Compounds References
Toxoplasma gondii enoyl-acyl carrier reductase ENR Compounds References
Staphylococcus aureus Enoyl-[acyl-carrier-protein] reductase [NADPH] Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PBANKA_1229800 (Plasmodium berghei), enoyl-acyl carrier reductase
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