Detailed view for TP01_0043

Basic information

TDR Targets ID: 832923
Theileria parva, hexokinase, putative
Source Database / ID: 

pI: 7.1521 | Length (AA): 506 | MW (Da): 56806 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00349   Hexokinase
PF03727   Hexokinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016773   phosphotransferase activity, alcohol group as acceptor  
GO:0005536   glucose binding  
GO:0004396   hexokinase activity  
GO:0001678   cellular glucose homeostasis  
GO:0005524   ATP binding  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 503 4qs8 (A) 41 487 33.00 0 1 1.19193 -0.01
44 504 1bg3 (A) 12 459 36.00 0 1 1.28517 -0.54
54 505 4qs8 (A) 41 489 30.00 0 1 1.25678 -0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126743)

Species Accession Gene Product
Arabidopsis thaliana AT4G29130   hexokinase 1
Arabidopsis thaliana AT1G47840   hexokinase 3
Arabidopsis thaliana AT2G19860   hexokinase 2
Babesia bovis BBOV_I000860   hexokinase
Brugia malayi Bm1_41805   Hexokinase family protein
Brugia malayi Bm1_36055   hexokinase
Candida albicans CaO19.734   one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)
Candida albicans CaO19.8353   one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)
Candida albicans CaO19.7686   one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)
Candida albicans CaO19.1408   one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)
Candida albicans CaO19.8176   similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose
Candida albicans CaO19.6116   one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)
Candida albicans CaO19.13535   one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)
Candida albicans CaO19.542   similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose
Candida albicans CaO19.13   one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W)
Caenorhabditis elegans CELE_F14B4.2   Protein F14B4.2, isoform A
Cryptosporidium hominis Chro.60435   hexokinase i
Cryptosporidium parvum cgd6_3800   hexokinase
Drosophila melanogaster Dmel_CG8094   Hexokinase C
Drosophila melanogaster Dmel_CG3001   Hexokinase A
Echinococcus granulosus EgrG_000571200   hexokinase type 2
Echinococcus granulosus EgrG_000571500   hexokinase
Echinococcus granulosus EgrG_000991700   hexokinase
Echinococcus granulosus EgrG_000990400   hexokinase
Entamoeba histolytica EHI_098290   hexokinase 1
Entamoeba histolytica EHI_098560   hexokinase 2
Echinococcus multilocularis EmuJ_000991700   hexokinase
Echinococcus multilocularis EmuJ_000571500   hexokinase
Echinococcus multilocularis EmuJ_000990400   hexokinase
Echinococcus multilocularis EmuJ_000571200   hexokinase type 2
Homo sapiens ENSG00000106633   glucokinase (hexokinase 4)
Homo sapiens ENSG00000160883   hexokinase 3 (white cell)
Homo sapiens ENSG00000159399   hexokinase 2
Homo sapiens ENSG00000156510   hexokinase domain containing 1
Homo sapiens ENSG00000156515   hexokinase 1
Leishmania braziliensis LbrM.21.0310   hexokinase, putative
Leishmania donovani LdBPK_210300.1   hexokinase, putative
Leishmania infantum LinJ.21.0300   hexokinase, putative
Leishmania infantum LinJ.21.0310   hexokinase, putative
Leishmania major LmjF.21.0250   hexokinase, putative
Leishmania major LmjF.21.0240   hexokinase, putative
Leishmania mexicana LmxM.21.0240   hexokinase, putative
Leishmania mexicana LmxM.21.0250   hexokinase, putative
Loa Loa (eye worm) LOAG_01379   hexokinase
Loa Loa (eye worm) LOAG_01380   hypothetical protein
Loa Loa (eye worm) LOAG_00481   hexokinase
Loa Loa (eye worm) LOAG_05652   hexokinase type II
Mus musculus ENSMUSG00000025877   hexokinase 3
Mus musculus ENSMUSG00000037012   hexokinase 1
Mus musculus ENSMUSG00000041798   glucokinase
Mus musculus ENSMUSG00000000628   hexokinase 2
Mus musculus ENSMUSG00000020080   hexokinase domain containing 1
Neospora caninum NCLIV_039820   cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related
Oryza sativa 4343113   Os07g0446800
Oryza sativa 4326776   Os01g0190400
Oryza sativa 4342654   Os07g0197100
Oryza sativa 4326547   Os01g0742500
Oryza sativa 4339361   Os05g0522500
Oryza sativa 4326516   Os01g0940100
Onchocerca volvulus OVOC1576  
Onchocerca volvulus OVOC558  
Onchocerca volvulus OVOC306  
Plasmodium berghei PBANKA_1122900   hexokinase, putative
Plasmodium falciparum PF3D7_0624000   hexokinase
Plasmodium knowlesi PKNH_1126200   hexokinase, putative
Plasmodium vivax PVX_114315   hexokinase, putative
Plasmodium yoelii PY02030   hexokinase
Saccharomyces cerevisiae YCL040W   glucokinase
Saccharomyces cerevisiae YGL253W   hexokinase 2
Saccharomyces cerevisiae YFR053C   hexokinase 1
Saccharomyces cerevisiae YDR516C   putative glucokinase
Schistosoma japonicum Sjp_0302060   ko:K00844 hexokinase [EC2.7.1.1], putative
Schistosoma mansoni Smp_043030   hexokinase
Schmidtea mediterranea mk4.006200.01   Hexokinase
Schmidtea mediterranea mk4.000389.10  
Schmidtea mediterranea mk4.006200.00   Hexokinase
Schmidtea mediterranea mk4.000389.09  
Trypanosoma brucei gambiense Tbg972.10.2400   hexokinase, putative
Trypanosoma brucei gambiense Tbg972.10.2420   hexokinase, putative
Trypanosoma brucei Tb927.10.2010   hexokinase
Trypanosoma brucei Tb11.v5.0732   hexokinase, putative
Trypanosoma brucei Tb927.10.2020   hexokinase
Trypanosoma congolense TcIL3000_0_38940   hexokinase
Trypanosoma cruzi TcCLB.508951.20   hexokinase, putative
Trypanosoma cruzi TcCLB.510121.20   hexokinase, putative
Toxoplasma gondii TGME49_265450   hexokinase
Treponema pallidum TP0505   hexokinase (hxk)
Theileria parva TP01_0045   hexokinase, putative
Theileria parva TP01_0043   hexokinase, putative

Essentiality

TP01_0043 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2010 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.2010 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.2010 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.2010 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F14B4.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F14B4.2 Caenorhabditis elegans slow growth wormbase
PBANKA_1122900 Plasmodium berghei Essential plasmo
TGME49_265450 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma brucei hexokinase Compounds References
Trypanosoma cruzi hexokinase, putative Compounds References
Homo sapiens hexokinase 2 Compounds References
Homo sapiens hexokinase 1 Compounds References
Rattus norvegicus Hexokinase type IV Compounds References
Trypanosoma cruzi hexokinase, putative Compounds References
Mus musculus glucokinase Compounds References
Homo sapiens hexokinase domain containing 1 Compounds References
Homo sapiens glucokinase (hexokinase 4) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TP01_0043 (Theileria parva), hexokinase, putative
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