Detailed view for TP03_0014

Basic information

TDR Targets ID: 833929
Theileria parva, hypothetical protein
Source Database / ID: 

pI: 6.126 | Length (AA): 367 | MW (Da): 42934 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00385   Chromo (CHRromatin Organisation MOdifier) domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
60 121 2rsn (A) 13 75 42.00 0 1 0.670637 -0.81
66 117 3tzd (A) 27 81 52.00 0 1 0.737389 -1.17
116 231 4tql (A) 56 177 22.00 0.024 0.24 0.759976 -2.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129545)

Species Accession Gene Product
Arabidopsis thaliana AT5G17690   chromo domain-containing protein LHP1
Brugia malayi Bm1_45290   Heterochromatin protein 1
Caenorhabditis elegans CELE_K08H2.6   Protein HPL-1
Caenorhabditis elegans CELE_K01G5.2   Protein HPL-2, isoform A
Dictyostelium discoideum DDB_G0282987   HP1-like protein
Dictyostelium discoideum DDB_G0283023   HP1-like protein
Dictyostelium discoideum DDB_G0270198   HP1-like protein
Drosophila melanogaster Dmel_CG7041   Heterochromatin Protein 1b
Drosophila melanogaster Dmel_CG8409   Suppressor of variegation 205
Drosophila melanogaster Dmel_CG43352   Heterochromatin Protein 1L chromoshadow domain
Echinococcus granulosus EgrG_000492600   chromobox protein 1
Echinococcus granulosus EgrG_000830000   chromobox protein 1
Echinococcus multilocularis EmuJ_000492600   chromobox protein 1
Echinococcus multilocularis EmuJ_000830000   chromobox protein 1
Homo sapiens ENSG00000108468   chromobox homolog 1
Loa Loa (eye worm) LOAG_03522   heterochromatin protein 1
Loa Loa (eye worm) LOAG_12932   hypothetical protein
Mus musculus ENSMUSG00000018666   chromobox 1
Onchocerca volvulus OVOC8431   Heterochromatin protein 1 homolog
Onchocerca volvulus OVOC5537  
Schistosoma japonicum Sjp_0217300   Chromobox protein homolog 5, putative
Schistosoma mansoni Smp_179650.1   chromobox protein
Schistosoma mansoni Smp_179650.2   chromobox protein
Schmidtea mediterranea mk4.005953.00   Putative chromobox protein
Theileria parva TP03_0014   hypothetical protein
Trichomonas vaginalis TVAG_160080   chromobox protein, putative
Trichomonas vaginalis TVAG_240130   chromobox protein, putative
Trichomonas vaginalis TVAG_021570   chromobox protein, putative
Trichomonas vaginalis TVAG_293880   chromobox protein, putative

Essentiality

TP03_0014 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K08H2.6 Caenorhabditis elegans larval arrest wormbase
CELE_K01G5.2 Caenorhabditis elegans larval lethal wormbase
CELE_K01G5.2 Caenorhabditis elegans slow growth wormbase
CELE_K01G5.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens chromobox homolog 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TP03_0014 (Theileria parva), hypothetical protein
Title for this comment
Comment