Detailed view for TVAG_051090

Basic information

TDR Targets ID: 842435
Trichomonas vaginalis, Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase
Source Database / ID: 

pI: 6.1202 | Length (AA): 665 | MW (Da): 73603 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00326   Prolyl oligopeptidase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008236   serine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130255)

Species Accession Gene Product
Arabidopsis thaliana AT4G14570   acylamino acid-releasing enzyme
Brugia malayi Bm1_43100   prolyl oligopeptidase family protein
Caenorhabditis elegans CELE_R11E3.8   Protein DPF-5
Cryptosporidium hominis Chro.50405   acylamino acid-releasing enzyme
Cryptosporidium parvum cgd5_4370   conserved hypothetical protein
Dictyostelium discoideum DDB_G0292456   N-acylpeptide hydrolase
Dictyostelium discoideum DDB_G0267742   hypothetical protein
Echinococcus granulosus EgrG_000843300   acylamino acid releasing enzyme
Echinococcus multilocularis EmuJ_000843300   acylamino acid releasing enzyme
Homo sapiens ENSG00000164062   acylaminoacyl-peptide hydrolase
Loa Loa (eye worm) LOAG_10957   hypothetical protein
Loa Loa (eye worm) LOAG_05245   hypothetical protein
Mus musculus ENSMUSG00000032590   acylpeptide hydrolase
Neospora caninum NCLIV_063570   Peptidase, S9A/B/C family, catalytic domain protein, related
Oryza sativa 4348628   Os10g0415800
Oryza sativa 4348626   Os10g0415600
Schmidtea mediterranea mk4.027732.00  
Schmidtea mediterranea mk4.027568.00   Acylaminoacyl-peptidase
Schmidtea mediterranea mk4.013093.00  
Toxoplasma gondii TGME49_246800   acylaminoacyl-peptidase, putative
Trichomonas vaginalis TVAG_051090   Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase

Essentiality

TVAG_051090 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_246800 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_051090 (Trichomonas vaginalis), Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase
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