Detailed view for TVAG_143320

Basic information

TDR Targets ID: 843668
Trichomonas vaginalis, Na+ driven multidrug efflux pump, putative
Source Database / ID: 

pI: 7.3798 | Length (AA): 240 | MW (Da): 25755 | Paralog Number: 53

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01554   MatE

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0015297   antiporter activity  
GO:0015238   drug transporter activity  
GO:0055085   transmembrane transport  
GO:0006855   multidrug transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127776)

Species Accession Gene Product
Giardia lamblia GL50803_17326   Na+ driven multidrug efflux pump
Giardia lamblia GL50803_15269   Na+ driven multidrug efflux pump
Oryza sativa 4347624   Os09g0524300
Oryza sativa 9271721   Os08g0545900
Trichomonas vaginalis TVAG_487120   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_150400   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_316950   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_116450   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_403860   conserved hypothetical protein
Trichomonas vaginalis TVAG_369180   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_289610   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_143310   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_304400   conserved hypothetical protein
Trichomonas vaginalis TVAG_376040   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_363490   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_403850   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_000230   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_338600   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_090110   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_304390   conserved hypothetical protein
Trichomonas vaginalis TVAG_436530   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_424110   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_199080   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_150700   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_306090   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_291970   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_026450   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_213620   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_393090   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_213630   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_143280   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_304360   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_181980   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_232430   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_483040   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_423670   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_261990   conserved hypothetical protein
Trichomonas vaginalis TVAG_143320   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_064460   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_449830   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_219800   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_210540   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_088450   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_411710   conserved hypothetical protein
Trichomonas vaginalis TVAG_430120   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_343290   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_206000   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_476630   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_000140   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_000120   conserved hypothetical protein
Trichomonas vaginalis TVAG_254920   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_436720   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_376030   conserved hypothetical protein
Trichomonas vaginalis TVAG_261980   conserved hypothetical protein
Trichomonas vaginalis TVAG_478850   Na+ driven multidrug efflux pump, putative
Trichomonas vaginalis TVAG_124880   multidrug resistance pump, putative
Trichomonas vaginalis TVAG_143330   conserved hypothetical protein
Trichomonas vaginalis TVAG_124890   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_143320 (Trichomonas vaginalis), Na+ driven multidrug efflux pump, putative
Title for this comment
Comment