Detailed view for TVAG_176450

Basic information

TDR Targets ID: 845721
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 7.2496 | Length (AA): 505 | MW (Da): 57852 | Paralog Number: 9

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02366   Dolichyl-phosphate-mannose-protein mannosyltransferase
PF16192   C-terminal four TMM region of protein-O-mannosyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0000030   mannosyltransferase activity  
GO:0006493   protein amino acid O-linked glycosylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129282)

Species Accession Gene Product
Candida albicans CaO19.14104   similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues
Candida albicans CaO19.3802   similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues
Candida albicans CaO19.11283   similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues
Candida albicans CaO19.6812   similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues
Drosophila melanogaster Dmel_CG12311   Protein O-mannosyltransferase 2
Homo sapiens ENSG00000009830   protein-O-mannosyltransferase 2
Mus musculus ENSMUSG00000034126   protein-O-mannosyltransferase 2
Saccharomyces cerevisiae YGR199W   dolichyl-phosphate-mannose-protein mannosyltransferase PMT6
Saccharomyces cerevisiae YOR321W   dolichyl-phosphate-mannose-protein mannosyltransferase PMT3
Saccharomyces cerevisiae YAL023C   dolichyl-phosphate-mannose-protein mannosyltransferase PMT2
Trichomonas vaginalis TVAG_393940   conserved hypothetical protein
Trichomonas vaginalis TVAG_497070   conserved hypothetical protein
Trichomonas vaginalis TVAG_117070   conserved hypothetical protein
Trichomonas vaginalis TVAG_300140   conserved hypothetical protein
Trichomonas vaginalis TVAG_028300   conserved hypothetical protein
Trichomonas vaginalis TVAG_172000   conserved hypothetical protein
Trichomonas vaginalis TVAG_106530   mannosyltransferase 1, putative
Trichomonas vaginalis TVAG_176450   conserved hypothetical protein
Trichomonas vaginalis TVAG_017390   mannosyltransferase 1, putative
Trichomonas vaginalis TVAG_199200   mannosyltransferase 1, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_176450 (Trichomonas vaginalis), conserved hypothetical protein
Title for this comment
Comment