pI: 4.9618 |
Length (AA): 1137 |
MW (Da): 128725 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126924)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_55530 | beta-G spectrin, identical |
Brugia malayi | Bm1_22625 | probable spectrin beta chain |
Brugia malayi | Bm1_27855 | Spectrin alpha chain |
Brugia malayi | Bm1_52790 | beta-G spectrin |
Caenorhabditis elegans | CELE_R31.1 | Protein SMA-1, isoform B |
Caenorhabditis elegans | CELE_K11C4.3 | Protein UNC-70, isoform B |
Caenorhabditis elegans | CELE_K10B3.10 | Protein SPC-1, isoform A |
Drosophila melanogaster | Dmel_CG5870 | beta Spectrin |
Drosophila melanogaster | Dmel_CG12008 | karst |
Drosophila melanogaster | Dmel_CG1977 | alpha Spectrin |
Echinococcus granulosus | EgrG_000243500 | spectrin beta chain |
Echinococcus granulosus | EgrG_000849000 | spectrin beta chain |
Echinococcus granulosus | EgrG_000650120 | spectrin beta chain, erythrocyte |
Echinococcus granulosus | EgrG_000486600 | Spectrin alpha actinin |
Echinococcus granulosus | EgrG_000151600 | Spectrin alpha actinin |
Echinococcus multilocularis | EmuJ_000849900 | Spectrin beta chain brain 3 |
Echinococcus multilocularis | EmuJ_000004400 | Spectrin beta chain brain 3 |
Echinococcus multilocularis | EmuJ_000243500 | |
Echinococcus multilocularis | EmuJ_000486600 | Spectrin alpha actinin |
Echinococcus multilocularis | EmuJ_000151600 | Spectrin alpha actinin |
Echinococcus multilocularis | EmuJ_000849000 | spectrin beta chain |
Echinococcus multilocularis | EmuJ_000139000 | zinc finger, C2H2 type |
Echinococcus multilocularis | EmuJ_000023200 | Spectrin alpha actinin |
Echinococcus multilocularis | EmuJ_000650100 | Pleckstrin y |
Echinococcus multilocularis | EmuJ_000650120 | |
Homo sapiens | ENSG00000197694 | spectrin, alpha, non-erythrocytic 1 |
Homo sapiens | ENSG00000137877 | spectrin, beta, non-erythrocytic 5 |
Homo sapiens | ENSG00000115306 | spectrin, beta, non-erythrocytic 1 |
Homo sapiens | ENSG00000070182 | spectrin, beta, erythrocytic |
Homo sapiens | ENSG00000163554 | spectrin, alpha, erythrocytic 1 |
Homo sapiens | ENSG00000173898 | spectrin, beta, non-erythrocytic 2 |
Homo sapiens | ENSG00000160460 | spectrin, beta, non-erythrocytic 4 |
Loa Loa (eye worm) | LOAG_10744 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10975 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02130 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06581 | Spna2 protein |
Loa Loa (eye worm) | LOAG_15931 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12941 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10976 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05013 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04011 | hypothetical protein |
Mus musculus | ENSMUSG00000067889 | spectrin beta, non-erythrocytic 2 |
Mus musculus | ENSMUSG00000020315 | spectrin beta, non-erythrocytic 1 |
Mus musculus | ENSMUSG00000057738 | spectrin alpha, non-erythrocytic 1 |
Mus musculus | ENSMUSG00000011751 | spectrin beta, non-erythrocytic 4 |
Mus musculus | 640524 | spectrin beta, non-erythrocytic 5 |
Mus musculus | ENSMUSG00000021061 | spectrin beta, erythrocytic |
Mus musculus | ENSMUSG00000026532 | spectrin alpha, erythrocytic 1 |
Schistosoma japonicum | Sjp_0086140 | Spectrin beta chain, erythrocyte, putative |
Schistosoma japonicum | Sjp_0091570 | Spectrin beta chain, putative |
Schistosoma japonicum | Sjp_0314410 | Spectrin beta chain, putative |
Schistosoma japonicum | Sjp_0119700 | Spectrin beta chain, putative |
Schistosoma japonicum | Sjp_0302210 | IPR003604,Zinc finger, U1-type;IPR007087,Zinc finger, C2H2-type,domain-containing |
Schistosoma japonicum | Sjp_0119780 | Spectrin beta chain, putative |
Schistosoma japonicum | Sjp_0017310 | ko:K06115 spectrin beta, putative |
Schistosoma japonicum | Sjp_0038660 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0034150 | ko:K06114 spectrin alpha, putative |
Schistosoma japonicum | Sjp_0091560 | Spectrin beta chain, brain 1, putative |
Schistosoma mansoni | Smp_143470.1 | Spectrin beta chain brain 3 (Spectrin non-erythroid beta chain 3) (Beta-IV spectrin) |
Schistosoma mansoni | Smp_128920 | alpha-actinin |
Schistosoma mansoni | Smp_170310 | hypothetical protein |
Schistosoma mansoni | Smp_128930 | hypothetical protein |
Schistosoma mansoni | Smp_143470.2 | Spectrin beta chain brain 3 (Spectrin non-erythroid beta chain 3) (Beta-IV spectrin) |
Schmidtea mediterranea | mk4.001226.00 | |
Schmidtea mediterranea | mk4.007578.00 | Spectrin beta chain |
Schmidtea mediterranea | mk4.012777.00 | Spectrin beta chain, brain 4 |
Schmidtea mediterranea | mk4.004981.04 | Spectrin beta chain |
Schmidtea mediterranea | mk4.012174.02 | Spectrin alpha chain |
Schmidtea mediterranea | mk4.019898.01 | |
Schmidtea mediterranea | mk4.033946.00 | |
Schmidtea mediterranea | mk4.003579.03 | |
Schmidtea mediterranea | mk4.019898.00 | Spectrin beta chain, non-erythrocytic 4 |
Schmidtea mediterranea | mk4.001623.02 | |
Schmidtea mediterranea | mk4.012174.00 | Uncharacterized calcium-binding protein |
Schmidtea mediterranea | mk4.001226.02 | |
Schmidtea mediterranea | mk4.004981.02 | |
Schmidtea mediterranea | mk4.003579.00 | Spectrin beta chain, non-erythrocytic 4 |
Schmidtea mediterranea | mk4.009111.00 | Spectrin beta chain, brain 4 |
Schmidtea mediterranea | mk4.004981.03 | |
Schmidtea mediterranea | mk4.009111.01 | Spectrin alpha chain |
Schmidtea mediterranea | mk4.001226.01 | |
Schmidtea mediterranea | mk4.005764.00 | |
Schmidtea mediterranea | mk4.007578.01 | |
Schmidtea mediterranea | mk4.005915.01 | Spectrin beta chain |
Schmidtea mediterranea | mk4.001623.03 | Spectrin beta chain, non-erythrocytic 4 |
Schmidtea mediterranea | mk4.005764.01 | Spectrin beta chain |
Schmidtea mediterranea | mk4.003579.01 | Spectrin beta chain |
Schmidtea mediterranea | mk4.012174.01 | Spectrin alpha chain |
Schmidtea mediterranea | mk4.003768.00 | Spectrin beta chain |
Trichomonas vaginalis | TVAG_247460 | beta chain spectrin, putative |
Trichomonas vaginalis | TVAG_247470 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_R31.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K10B3.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K10B3.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K10B3.10 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_K11C4.3 | Caenorhabditis elegans | slow growth | wormbase |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.