Detailed view for TVAG_145340

Basic information

TDR Targets ID: 854814
Trichomonas vaginalis, alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative

Source Database / ID: 

pI: 4.9328 | Length (AA): 525 | MW (Da): 59165 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF16499   Alpha galactosidase A

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0030246   carbohydrate binding  
GO:0003824   catalytic activity  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127620)

Species Accession Gene Product
Arabidopsis thaliana AT3G56310   melibiase family protein
Arabidopsis thaliana AT5G08380   alpha-galactosidase 1
Arabidopsis thaliana AT5G08370   alpha-galactosidase 2
Brugia malayi Bm1_51545   Melibiase family protein
Caenorhabditis elegans CELE_R07B7.11   Protein GANA-1
Dictyostelium discoideum DDB_G0271490   hypothetical protein
Dictyostelium discoideum DDB_G0291524   glycoside hydrolase family 27 protein
Drosophila melanogaster Dmel_CG7997   CG7997 gene product from transcript CG7997-RB
Drosophila melanogaster Dmel_CG5731   CG5731 gene product from transcript CG5731-RA
Echinococcus granulosus EgrG_000340500   Alpha N acetylgalactosaminidase
Echinococcus multilocularis EmuJ_000340500   Alpha N acetylgalactosaminidase
Echinococcus multilocularis EmuJ_000340400   Glycoside hydrolase, family 27
Homo sapiens ENSG00000102393   galactosidase, alpha
Homo sapiens ENSG00000198951   N-acetylgalactosaminidase, alpha-
Loa Loa (eye worm) LOAG_00060   hypothetical protein
Mus musculus ENSMUSG00000031266   galactosidase, alpha
Mus musculus ENSMUSG00000022453   N-acetyl galactosaminidase, alpha
Neospora caninum NCLIV_054050   hypothetical protein
Oryza sativa 4348988   Os10g0493600
Oryza sativa 4348984   Os10g0492900
Oryza sativa 4344290   Os07g0679300
Schistosoma japonicum Sjp_0023240   Alpha-N-acetylgalactosaminidase precursor, putative
Schistosoma japonicum Sjp_0023210   expressed protein
Schistosoma japonicum Sjp_0023250   Alpha-N-acetylgalactosaminidase, putative
Schistosoma japonicum Sjp_0023260   ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative
Schistosoma japonicum Sjp_0107620   Alpha-N-acetylgalactosaminidase, putative
Schistosoma japonicum Sjp_0023220   Alpha-N-acetylgalactosaminidase, putative
Schistosoma mansoni Smp_089290   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_179260   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_179250   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_186710   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_170830   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schistosoma mansoni Smp_170840   alpha-galactosidase/alpha-n-acetylgalactosaminidase
Schmidtea mediterranea mk4.003634.02  
Schmidtea mediterranea mk4.005290.02  
Schmidtea mediterranea mk4.000843.06  
Toxoplasma gondii TGME49_309930   melibiase subfamily protein
Trichomonas vaginalis TVAG_145340   alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative

Essentiality

TVAG_145340 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_309930 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Coffea arabica Alpha-galactosidase Compounds References
Rattus norvegicus Alpha-galactosidase A Compounds References
Coffea arabica Alpha-galactosidase Compounds References
Homo sapiens galactosidase, alpha Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0074 0.2526 0.5
0.0065 0.3592 1
0.0069 0.3002 0.9857
0.0082 0.2688 0.2688
0.0266 0.3195 0.9549
0.0073 0.2531 0.5
0.0082 0.3618 1
0.0082 0.6299 1
0.007 0.2681 1
0.0266 0.3566 1
0.0071 0.6119 1
0.0073 0.6119 1
0.0071 0.391 1
0.0082 0.2534 0.1408
0.0071 0.2969 1
0.0075 0.3863 0.479
0.0232 0.2789 0.8424
0.0082 0.5581 0.5
0.0277 0.2977 1
0.0082 0.2758 1
0.0082 0.3791 1
0.0074 0.2608 0.577
0.0067 0.3128 0.5
0.008 0.3323 0.5
0.0075 0.5186 0.5
0.0073 0.3886 1
0.0083 0.292 0.5
0.0067 0.5018 1
0.0082 0.2534 0.1765
0.0134 0.2594 0.4536
0.0082 0.6566 1
0.0082 0.6299 1
0.0066 0.315 1
0.0082 0.3951 1
0.0137 0.3174 0.7096
0.0072 0.3735 0.5
0.0079 0.3 1
0.0277 0.2977 1
0.0069 0.2604 0.252
0.0082 0.5919 1
0.0082 0.3989 0.5
0.0071 0.6119 0.5
0.0082 0.277 1
0.0082 0.3144 1
0.0079 0.2605 0
0.0082 0.4166 0.5
0.0071 0.2555 1
0.0082 0.3462 0.2314
0.0372 0.2501 0.4873
0.0068 0.3153 1
0.0069 0.2733 0.5
0.0082 0.2968 1
0.0067 0.2929 1
0.0384 0.4139 0.6459
0.0073 0.6121 0.5
0.0082 0.513 0.5
0.0082 0.3203 1
0.0076 0.3863 0.5287
0.0082 0.3791 0.5506
0.0082 0.4177 0.5
0.0082 0.6184 0.5
0.007 0.4589 1
0.0082 0.6119 1
0.0082 0.5343 1
0.008 0.5911 1
0.0082 0.6062 1
0.0068 0.3204 1
0.0082 0.3182 1
0.008 0.383 0.5
0.0082 0.2888 1
0.0216 0.4059 1
0.0082 0.5623 0.5
0.0082 0.5339 0.6752
0.0078 0.3515 1
0.0435 0.4776 1
0.0082 0.6162 1
0.0082 0.6062 1
0.0081 0.4322 1
0.0066 0.3211 0.628
0.0078 0.398 0.5
0.0079 0.4353 1
0.0082 0.6121 0.5
0.0082 0.6121 0.5
0.0082 0.6056 1
0.0344 0.4074 1
0.0138 0.638 1
0.0079 0.6061 0.5
0.0077 0.2929 0.5
0.0232 0.2789 0.8424
0.0067 0.5993 1
0.0319 0.2739 0.2739
0.0081 0.6119 1
0.0344 0.3411 1
0.0073 0.6121 0.5
0.0077 0.513 1
0.0071 0.3863 0.4252
0.0337 0.6122 0.9932
0.0082 0.5919 1
0.0082 0.2859 1
0.0082 0.6426 1
0.0217 0.4129 0.7432
0.0071 0.261 1
0.0074 0.398 0.5
0.0082 0.2848 0.9592
0.0138 0.3202 0.8214
0.0069 0.4773 0.5
0.0082 0.6304 1
0.0081 0.6119 0.5
0.0082 0.3868 1
0.0073 0.3042 0.5
0.0082 0.2627 1
0.0077 0.288 0.2861
0.0082 0.6062 0.5
0.007 0.519 0.5
0.0079 0.3 1
0.0148 0.3057 1
0.0078 0.4154 0.5
0.0077 0.6006 0.6624
0.0076 0.5919 1
0.0081 0.6119 0.5
0.0289 0.3225 0.3359
0.0082 0.3863 1
0.0082 0.3989 1
0.0069 0.3724 1
0.008 0.2594 0.1962
0.0075 0.4099 0.5532
0.0076 0.5919 1
0.0071 0.3823 1
0.0269 0.2974 0.9394
0.0069 0.3451 1
0.0078 0.3515 1
0.0082 0.2938 1
0.0082 0.5581 0.5
0.0076 0.2723 1
0.007 0.2886 1
0.0076 0.4341 1
0.0082 0.507 1
0.0074 0.3863 1
0.0082 0.5919 1
0.0082 0.613 0.5
0.008 0.3143 1
0.0347 0.32 1
0.0082 0.3278 0.5509
0.0082 0.3009 0.2889
0.0069 0.3385 1
0.0073 0.2835 0.9596
0.007 0.6121 1
0.0082 0.2685 1
0.008 0.2693 1
0.0082 0.6056 1
0.0076 0.6121 0.5
0.0074 0.315 1
0.0077 0.381 1
0.0071 0.2673 1
0.007 0.3121 1
0.0068 0.5895 1
0.0071 0.5724 1
0.0082 0.2919 0.5
0.0071 0.2536 0.9592
0.0079 0.3985 0.5
0.0082 0.4363 1
0.0082 0.654 1
0.0082 0.6119 0.5
0.0433 0.6072 1
0.0079 0.2605 0
0.0388 0.2703 0.5177
0.0067 0.3863 1
0.0077 0.2644 1
0.007 0.3024 0.393
0.008 0.2521 1
0.0075 0.3431 0.5
0.0276 0.3867 1
0.0082 0.513 0.5
0.0074 0.4035 1
0.0077 0.2637 0.2637
0.0082 0.2592 0.2134
0.0068 0.3344 0.5
0.0079 0.4205 1
0.0334 0.6481 1
0.0227 0.3013 0.3786
0.0069 0.6119 0.5
0.0082 0.398 0.5
0.0144 0.2996 0.5371
0.007 0.2734 1
0.0082 0.3472 0.5
0.008 0.251 0
0.0068 0.5895 1
0.0067 0.5919 1
0.0082 0.6061 0.5
0.0067 0.3344 0.5
0.0153 0.3366 0.9085
0.0383 0.4857 0.5064
0.0075 0.263 0.2619
0.0082 0.3939 1
0.0067 0.3449 0.4025
0.0082 0.5919 1
0.0074 0.274 0.5935
0.0059 0.3076 0.5733
0.0082 0.5545 0.5
0.0078 0.459 0.9674
0.0229 0.2785 0.3893
0.0073 0.5594 0.5
0.0074 0.3422 1
0.0082 0.6119 0.5
0.0082 0.6119 0.5
0.0077 0.5839 0.8219
0.007 0.2686 1
0.0082 0.3471 1
0.0082 0.5919 1
0.0082 0.3755 0.5
0.0077 0.2536 0.3835
0.0073 0.2743 1
0.0137 0.3656 1
0.0071 0.254 0.4284
0.0082 0.6062 0.5
0.0078 0.4154 0.5
0.0071 0.4984 1
0.0082 0.398 0.5
0.0082 0.2987 0.5
0.0066 0.351 1
0.0082 0.259 1
0.0072 0.3241 1
0.0082 0.3688 1
0.0082 0.315 1
0.0082 0.3627 1
0.0082 0.6039 1
0.0071 0.3811 0.5
0.0068 0.3168 1
0.0082 0.2637 0.2584
0.0067 0.6039 1
0.0081 0.2709 1
0.0075 0.3863 0.5287
0.0082 0.2988 0.5
0.0082 0.2603 0.3006
0.0069 0.5895 1
0.0082 0.2668 0.2668
0.007 0.504 0.5
0.008 0.495 0.5
0.0082 0.3863 1
0.0277 0.2977 1
0.0082 0.3557 1
0.0071 0.2545 1
0.0082 0.3392 1
0.0081 0.2582 1
0.0278 0.2517 1
0.0082 0.2585 0.2115
0.0082 0.6119 0.5
0.0076 0.2716 0.2675
0.0072 0.398 0.5
0.0074 0.5919 1
0.0066 0.3291 1
0.0082 0.453 1
0.0072 0.29 1
0.0279 0.2593 0.519
0.0078 0.2767 1
0.0072 0.2902 0.5
0.0082 0.3939 1
0.0076 0.375 0.5083
0.0066 0.3277 1
0.0079 0.6184 0.5
0.0148 0.3707 1
0.0418 0.371 0.558
0.0082 0.3376 0.5
0.0071 0.5919 1
0.0074 0.28 1
0.0082 0.3144 1
0.0082 0.362 1
0.0066 0.3242 1
0.0074 0.3379 1
0.0358 0.4952 1
0.0066 0.3639 0.5
0.0075 0.3207 1
0.0082 0.4142 1
0.0073 0.2743 1
0.0343 0.3957 0.9597
0.0082 0.3001 1
0.0146 0.3472 0.4521
0.0076 0.4307 0.5
0.0066 0.2988 1
0.0082 0.6039 0.5
0.007 0.507 1
0.0082 0.3334 0.9674
0.0378 0.4119 0.5301
0.0388 0.5179 0.767
0.0074 0.3472 0.665
0.0082 0.5545 0.5
0.0066 0.3005 0.9674
0.0067 0.4429 0.5
0.0146 0.3109 1
0.0073 0.3472 0.665
0.0075 0.2646 1
0.0273 0.2591 0.5141
0.0441 0.5029 0.6486
0.0078 0.3515 1
0.0082 0.6119 0.5
0.0075 0.3909 0.5
0.0082 0.513 1
0.0082 0.6426 1
0.0082 0.613 0.5
0.0082 0.5919 1
0.0082 0.4474 0.5
0.0075 0.3242 1
0.0274 0.3942 0.7654
0.0074 0.3736 0.5
0.0082 0.357 1
0.0344 0.3411 1
0.0077 0.5863 1
0.0079 0.6119 0.5
0.0082 0.3264 1
0.0074 0.2553 1
0.0075 0.4125 1
0.0082 0.3791 1
0.0082 0.3869 1
0.007 0.6164 1
0.0076 0.3036 0.2724
0.0082 0.3635 0.3375
0.022 0.3608 0.3457
0.0071 0.3077 1
0.0083 0.292 0.5
0.0151 0.3361 0.9068
0.0082 0.398 0.5
0.0055 0.2547 0.2474
0.0082 0.2765 0.2765
0.0079 0.3 1
0.081 0.2911 0.8431
0.0082 0.2988 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_145340 (Trichomonas vaginalis), alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative
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