Detailed view for TVAG_065740

Basic information

TDR Targets ID: 862493
Trichomonas vaginalis, tubulin gamma chain, putative

Source Database / ID: 

pI: 5.7993 | Length (AA): 434 | MW (Da): 48450 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF00091   Tubulin/FtsZ family, GTPase domain
PF03953   Tubulin C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005874   microtubule  
GO:0003924   GTPase activity  
GO:0005525   GTP binding  
GO:0007017   microtubule-based process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130726)

Species Accession Gene Product
Echinococcus granulosus EgrG_000603100   tubulin epsilon chain
Echinococcus multilocularis EmuJ_000603100   tubulin epsilon chain
Giardia lamblia GL50803_6336   Epsilon tubulin
Homo sapiens ENSG00000074935   tubulin, epsilon 1
Leishmania braziliensis LbrM.21.1240   epsilon tubulin, putative
Leishmania donovani LdBPK_211250.1   epsilon tubulin, putative
Leishmania infantum LinJ.21.1250   epsilon tubulin, putative
Leishmania major LmjF.21.1010   epsilon tubulin, putative
Leishmania mexicana LmxM.21.1010   epsilon tubulin, putative
Mus musculus ENSMUSG00000019845   epsilon-tubulin 1
Neospora caninum NCLIV_007070   tubulin epsilon chain, putative
Plasmodium berghei PBANKA_1300500   tubulin epsilon chain, putative
Plasmodium falciparum PF3D7_1475700   tubulin epsilon chain, putative
Plasmodium knowlesi PKNH_1246000   tubulin epsilon chain, putative
Plasmodium vivax PVX_118660   tubulin epsilon chain, putative
Plasmodium yoelii PY05777   tubulin beta chain
Schistosoma japonicum Sjp_0009290   ko:K10391 tubulin epsilon, putative
Schistosoma mansoni Smp_028360   tubulin subunit epsilon
Schmidtea mediterranea mk4.013167.01   Tubulin epsilon chain
Schmidtea mediterranea mk4.013167.02   Tubulin epsilon chain, putative
Schmidtea mediterranea mk4.016956.01   Tubulin epsilon chain, putative
Schmidtea mediterranea mk4.023212.00   Tubulin epsilon chain, putative
Schmidtea mediterranea mk4.016956.00  
Trypanosoma brucei gambiense Tbg972.10.1240   epsilon tubulin
Trypanosoma brucei Tb927.10.1140   epsilon tubulin
Trypanosoma brucei Tb11.0530   epsilon tubulin
Trypanosoma congolense TcIL3000_10_940   epsilon tubulin
Trypanosoma cruzi TcCLB.509967.160   epsilon tubulin, putative
Trypanosoma cruzi TcCLB.509695.120   epsilon tubulin, putative
Toxoplasma gondii TGME49_275970   tubulin, putative
Toxoplasma gondii TGME49_275870   tubulin/FtsZ family, GTPase domain-containing protein
Trichomonas vaginalis TVAG_065740 this record   tubulin gamma chain, putative

Essentiality

TVAG_065740 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1140 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.1140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.1140 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.1140 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1300500 Plasmodium berghei Dispensable plasmo
TGME49_275870 Toxoplasma gondii Probably non-essential sidik
TGME49_275970 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major epsilon tubulin, putative Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Tubulin 85 aa 28.9% 90 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0395 0.5316 0.5306
0.0116 0.3065 0.3065
0.0134 0.3392 0.3392
0.007 0.2831 0.7867
0.0798 0.4597 0.3418
0.0522 0.2879 0.2876
0.0505 0.5684 0.5656
0.0268 0.5259 0.4265
0.013 0.5084 0.4008
0.0258 0.3471 0.5248
0.0131 0.3392 0.3392
0.013 0.326 0.326
0.0294 0.4845 0.3816
0.0179 0.3551 0.3551
0.0182 0.4071 0.4035
0.044 0.5284 0.5262
0.0507 0.2651 0.2651
0.031 0.3516 0.5867
0.0522 0.2879 0.2876
0.0941 0.2835 0.5681
0.0344 0.3407 0.5303
0.2094 0.5351 0.535
0.0251 0.5402 0.5386
0.0261 0.2564 0.5373
0.0145 0.3392 0.3392
0.0196 0.3729 0.3729
0.063 0.6104 0.61
0.0263 0.3178 0.2732
0.0236 0.6661 1
0.2053 0.5373 0.5373
0.1147 0.3352 0.5678
0.0431 0.3843 0.3309
0.0134 0.3392 0.3392
0.0407 0.5054 0.5285
0.0966 0.2864 0.5655
0.0987 0.2669 0.5327
0.1813 0.552 0.552
0.0139 0.4532 0.4008
0.0145 0.5091 0.4681
0.1069 0.2988 0.5477
0.0873 0.5375 0.5368
0.0258 0.3496 0.2724
0.0132 0.462 0.4008
0.0912 0.2829 0.5676
0.0294 0.4845 0.3816
0.0137 0.5054 0.4188
0.2043 0.5382 0.5381
0.038 0.3692 0.5973
0.0812 0.4723 0.4723
0.0289 0.3725 0.3725
0.0134 0.3347 0.1672
0.0141 0.3392 0.3392
0.0812 0.4723 0.4723
0.1405 0.5136 0.3915
0.1408 0.4595 0.5516
0.2048 0.4878 0.5381
0.0139 0.3392 0.3392
0.0127 0.3392 0.3392
0.0136 0.3392 0.3392
0.0307 0.3446 0.5973
0.0184 0.2597 0.5493
0.0136 0.3392 0.3392
0.0362 0.3067 0.3161
0.0135 0.3392 0.3392
0.0286 0.2721 0.2721
0.0134 0.253 0.1672
0.0125 0.3392 0.3392
0.0929 0.2828 0.5677
0.1567 0.5381 0.538
0.0417 0.3295 0.5252
0.0993 0.5875 0.4799
0.0987 0.2813 0.5645
0.0352 0.4792 0.5993
0.0135 0.3392 0.3392
0.2141 0.5326 0.5326
0.0549 0.448 0.446
0.028 0.3145 0.3865
0.0129 0.4008 0.4008
0.0293 0.2733 0.3261
0.0273 0.3209 0.5017
0.1055 0.5384 0.5384
0.0559 0.5037 0.5034
0.2048 0.4878 0.5381
0.0181 0.3287 0.3583
0.0123 0.4335 0.4008
0.1905 0.5369 0.5369
0.104 0.2872 0.5637
0.0522 0.2879 0.2876
0.0249 0.3749 0.3749
0.0318 0.5975 0.5975
0.0617 0.2524 0.575
0.0491 0.5253 0.5252
0.0636 0.6053 0.6046
0.0812 0.4723 0.4723
0.0925 0.3824 0.5874
0.0207 0.3147 0.2722
0.1574 0.538 0.5379
0.2048 0.4878 0.5381
0.006 0.2882 1
0.046 0.2733 0.4477
0.0941 0.6046 0.602
0.0929 0.2832 0.5676
0.0145 0.3544 0.3392
0.2174 0.4299 0.5319
0.1366 0.5329 0.5323
0.0423 0.3287 0.5252
0.0333 0.3437 0.5306
0.0298 0.4717 0.4688
0.0182 0.3842 0.3411
0.0798 0.4597 0.3418
0.0253 0.3918 0.3918

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_065740 (Trichomonas vaginalis), tubulin gamma chain, putative
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