Detailed view for TVAG_414300

Basic information

TDR Targets ID: 862895
Trichomonas vaginalis, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative
Source Database / ID: 

pI: 6.4453 | Length (AA): 442 | MW (Da): 47957 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01676   Metalloenzyme superfamily
PF10143   2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene Ontology

Mouse over links to read term descriptions.
GO:0046537   2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity  
GO:0046872   metal ion binding  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131753)

Species Accession Gene Product
Arabidopsis thaliana AT3G30841   Cofactor-independent phosphoglycerate mutase
Arabidopsis thaliana AT4G09520   Cofactor-independent phosphoglycerate mutase
Dictyostelium discoideum DDB_G0277763   hypothetical protein
Leishmania braziliensis LbrM.28.2420   2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like
Leishmania donovani LdBPK_282380.1   2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like
Leishmania infantum LinJ.28.2380   2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like
Leishmania major LmjF.28.2220   2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like
Leishmania mexicana LmxM.28.2220   2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like
Trypanosoma brucei gambiense Tbg972.11.12900   2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like protein, putative
Trypanosoma brucei Tb927.11.11490   2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like protein, putative
Trypanosoma congolense TcIL3000.11.12090   2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like protein, putative
Trypanosoma cruzi TcCLB.511017.20   2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative
Trichomonas vaginalis TVAG_414300   2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative

Essentiality

TVAG_414300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.3340 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.3340 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.3340 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.3340 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_414300 (Trichomonas vaginalis), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative
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