Detailed view for TVAG_128700

Basic information

TDR Targets ID: 863071
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 5.3257 | Length (AA): 363 | MW (Da): 40832 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00288   GHMP kinases N terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131773)

Species Accession Gene Product
Arabidopsis thaliana AT1G31910   GHMP kinase family protein
Candida albicans CaO19.4606   phosphomevalonate kinase
Candida albicans CaO19.12076   phosphomevalonate kinase
Dictyostelium discoideum DDB_G0292666   hypothetical protein
Leishmania braziliensis LbrM.15.1450   phosphomevalonate kinase protein, putative
Leishmania donovani LdBPK_151510.1   phosphomevalonate kinase-like protein
Leishmania infantum LinJ.15.1510   phosphomevalonate kinase protein, putative
Leishmania major LmjF.15.1460   phosphomevalonate kinase protein, putative
Leishmania mexicana LmxM.15.1460   phosphomevalonate kinase-like protein
Mus musculus 102641231   phosphomevalonate kinase-like
Oryza sativa 4332275   Os03g0253100
Saccharomyces cerevisiae YMR220W   phosphomevalonate kinase
Trypanosoma brucei gambiense Tbg972.9.2730   phosphomevalonate kinase protein, putative
Trypanosoma brucei Tb927.9.5170   phosphomevalonate kinase protein, putative
Trypanosoma cruzi TcCLB.507913.20   phosphomevalonate kinase protein, putative
Trypanosoma cruzi TcCLB.508277.140   phosphomevalonate kinase protein, putative
Trichomonas vaginalis TVAG_128700   conserved hypothetical protein

Essentiality

TVAG_128700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.3690 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.160.3690 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.3690 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.160.3690 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YMR220W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_128700 (Trichomonas vaginalis), conserved hypothetical protein
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