Detailed view for TVAG_RG_DS114997_1

Basic information

TDR Targets ID: 863091
Trichomonas vaginalis, reverse transcriptase [C. elegans], putative
Source Database / ID: 

pI: 9.3094 | Length (AA): 782 | MW (Da): 88118 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00078   Reverse transcriptase (RNA-dependent DNA polymerase)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130546)

Species Accession Gene Product
Mycobacterium leprae ML1637c   conserved hypothetical protein
Mycobacterium ulcerans MUL_1324   bifunctional RNase H/acid phosphatase
Oryza sativa 4348807   Os10g0458700
Schistosoma japonicum Sjp_0046650   Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM, putative
Schistosoma japonicum Sjp_0210330   IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing
Schistosoma japonicum Sjp_0031020   Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM, putative
Schmidtea mediterranea mk4.006568.01  
Schmidtea mediterranea mk4.001125.15  
Schmidtea mediterranea mk4.001456.00  
Schmidtea mediterranea mk4.013091.00  
Schmidtea mediterranea mk4.000049.21  
Schmidtea mediterranea mk4.000507.02  
Schmidtea mediterranea mk4.016482.00  
Trichomonas vaginalis TVAG_088900   reverse transcriptases, putative
Trichomonas vaginalis TVAG_RG_DS114997_1   reverse transcriptase [C. elegans], putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_RG_DS114997_1 (Trichomonas vaginalis), reverse transcriptase [C. elegans], putative
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