Detailed view for TVAG_003650
Basic information
TDR Targets ID: 863511
Trichomonas vaginalis, Clan CA, family C1, papain-like cysteine peptidase
Source Database / ID:
Trichomonas vaginalis, Clan CA, family C1, papain-like cysteine peptidase
Source Database / ID:
pI: 5.9025 |
Length (AA): 310 |
MW (Da): 34705 |
Paralog Number:
26
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
Mouse over links to read term descriptions.
GO:0008234
cysteine-type peptidase activity GO:0006508 proteolysis
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
No model available for this protein in Modbase.
PDB Structures:
No structure availble in the PDB for this protein
Expression
No expression data available for this gene
Orthologs
Ortholog group members (OG5_126607)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT3G54940 | Papain family cysteine protease |
| Arabidopsis thaliana | AT1G20850 | xylem cysteine proteinase 2 |
| Arabidopsis thaliana | AT5G50260 | KDEL-tailed cysteine endopeptidase CEP1 |
| Arabidopsis thaliana | AT4G23520 | putative cysteine proteinase |
| Arabidopsis thaliana | AT4G39090 | cysteine proteinase RD19a |
| Arabidopsis thaliana | AT1G06260 | Cysteine proteinases superfamily protein |
| Arabidopsis thaliana | AT3G19390 | Granulin repeat cysteine protease family protein |
| Arabidopsis thaliana | AT5G43060 | Granulin repeat cysteine protease family protein |
| Arabidopsis thaliana | AT3G48340 | KDEL-tailed cysteine endopeptidase CEP2 |
| Arabidopsis thaliana | AT1G47128 | cysteine proteinase RD21a |
| Arabidopsis thaliana | AT4G16190 | papain family cysteine protease |
| Arabidopsis thaliana | AT2G21430 | Papain family cysteine protease |
| Arabidopsis thaliana | AT5G45890 | cysteine protease SAG12 |
| Brugia malayi | Bm1_53615 | Cathepsin L-like precursor |
| Brugia malayi | Bm1_00065 | Cathepsin L-like precursor |
| Brugia malayi | Bm1_19970 | Cathepsin L-like precursor |
| Brugia malayi | Bm1_20385 | Cathepsin L-like precursor |
| Brugia malayi | Bm1_26865 | Cathepsin L-like cysteine proteinase |
| Brugia malayi | Bm1_00870 | cathepsin L-like precursor |
| Brugia malayi | Bm1_19965 | Cathepsin L-like precursor |
| Brugia malayi | Bm1_16635 | Papain family cysteine protease containing protein |
| Brugia malayi | Bm1_02100 | Cathepsin L-like precursor |
| Brugia malayi | Bm1_53625 | Cathepsin L-like precursor |
| Brugia malayi | Bm1_13265 | Cathepsin L-like precursor |
| Caenorhabditis elegans | CELE_F41E6.6 | Protein TAG-196 |
| Caenorhabditis elegans | CELE_T03E6.7 | Protein CPL-1, isoform B |
| Caenorhabditis elegans | CELE_R09F10.1 | Protein R09F10.1 |
| Cryptosporidium hominis | Chro.60563 | cryptopain precursor |
| Cryptosporidium parvum | cgd6_4880 | cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus |
| Dictyostelium discoideum | DDB_G0278721 | cysteine protease 4 |
| Dictyostelium discoideum | DDB_G0274385 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0290957 | cysteine proteinase 1 |
| Dictyostelium discoideum | DDB_G0272298 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0279185 | cysteine proteinase |
| Dictyostelium discoideum | DDB_G0272815 | cysteine proteinase 5 precursor |
| Dictyostelium discoideum | DDB_G0279187 | cysteine proteinase |
| Dictyostelium discoideum | DDB_G0283867 | cysteine proteinase 3 |
| Dictyostelium discoideum | DDB_G0278401 | hypothetical protein |
| Dictyostelium discoideum | DDB_G0291191 | cysteine protease |
| Dictyostelium discoideum | DDB_G0279799 | cysteine protease |
| Drosophila melanogaster | Dmel_CG6692 | Cysteine proteinase-1 |
| Drosophila melanogaster | Dmel_CG12163 | CG12163 gene product from transcript CG12163-RB |
| Echinococcus granulosus | EgrG_000989200 | cathepsin l cysteine peptidase |
| Echinococcus granulosus | EgrG_000654500 | cathepsin L cysteine proteinase |
| Echinococcus granulosus | EgrG_002067400 | cathepsin l1 |
| Echinococcus granulosus | EgrG_000654800 | cathepsin l1 |
| Entamoeba histolytica | EHI_159610 | cysteine protease, putative |
| Entamoeba histolytica | EHI_168240 | cysteine proteinase, putative |
| Entamoeba histolytica | EHI_151440 | cysteine proteinase, putative |
| Entamoeba histolytica | EHI_050570 | cysteine proteinase, putative |
| Echinococcus multilocularis | EmuJ_000654200 | cathepsin L cysteine protease |
| Echinococcus multilocularis | EmuJ_000989200 | cathepsin l cysteine peptidase |
| Echinococcus multilocularis | EmuJ_000654100 | cathepsin l cysteine peptidase |
| Echinococcus multilocularis | EmuJ_000654600 | cysteine protease |
| Echinococcus multilocularis | EmuJ_000654800 | cathepsin L cysteine protease |
| Echinococcus multilocularis | EmuJ_000654500 | cysteine protease |
| Homo sapiens | ENSG00000143387 | cathepsin K |
| Homo sapiens | ENSG00000136943 | cathepsin V |
| Homo sapiens | ENSG00000174080 | cathepsin F |
| Homo sapiens | ENSG00000135047 | cathepsin L |
| Homo sapiens | ENSG00000163131 | cathepsin S |
| Leishmania braziliensis | LbrM.08.0810 | cathepsin L-like protease |
| Leishmania braziliensis | LbrM.08.0830 | cathepsin L-like protease |
| Leishmania braziliensis | LbrM.19.1690 | cysteine peptidase A (CPA) |
| Leishmania braziliensis | LbrM.08.0820 | cathepsin L-like protease |
| Leishmania donovani | LdBPK_191460.1 | cysteine peptidase A (CBA) |
| Leishmania infantum | LinJ.19.1460 | cysteine peptidase A (CPA) |
| Leishmania infantum | LinJ.08.0960 | cathepsin L-like protease |
| Leishmania infantum | LinJ.08.0950 | cathepsin L-like protease |
| Leishmania major | LmjF.08.1030 | cathepsin L-like protease |
| Leishmania major | LmjF.08.1010 | cathepsin L-like protease |
| Leishmania major | LmjF.19.1420 | cysteine peptidase A (CPA) |
| Leishmania major | LmjF.08.1070 | cathepsin L-like protease |
| Leishmania major | LmjF.08.1020 | cathepsin L-like protease |
| Leishmania major | LmjF.08.1040 | cathepsin L-like protease |
| Leishmania major | LmjF.08.1080 | cathepsin L-like protease |
| Leishmania major | LmjF.08.1050 | cathepsin L-like protease |
| Leishmania major | LmjF.08.1060 | cathepsin L-like protease |
| Leishmania mexicana | LmxM.08.1040b | |
| Leishmania mexicana | LmxM.08.1040c | |
| Leishmania mexicana | LmxM.08.1030a | |
| Leishmania mexicana | LmxM.08.1070partial | |
| Leishmania mexicana | LmxM.08.1080 | cathepsin L-like protease, putative |
| Leishmania mexicana | LmxM.08.1040 | |
| Leishmania mexicana | LmxM.08.1070 | cathepsin L-like protease, putative |
| Leishmania mexicana | LmxM.19.1420 | cysteine peptidase A (CBA) |
| Loa Loa (eye worm) | LOAG_09865 | cysteine protease |
| Loa Loa (eye worm) | LOAG_11608 | fibroinase |
| Loa Loa (eye worm) | LOAG_01434 | papain family cysteine protease containing protein |
| Loa Loa (eye worm) | LOAG_12600 | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein |
| Loa Loa (eye worm) | LOAG_07188 | ctsf protein |
| Loa Loa (eye worm) | LOAG_15105 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_12602 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_12683 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_15647 | hypothetical protein |
| Mus musculus | ENSMUSG00000021477 | cathepsin L |
| Mus musculus | ENSMUSG00000042243 | cDNA sequence BC051665 |
| Mus musculus | ENSMUSG00000038642 | cathepsin S |
| Mus musculus | ENSMUSG00000083282 | cathepsin F |
| Mus musculus | ENSMUSG00000056728 | cathepsin L-like 3 |
| Neospora caninum | NCLIV_004380 | Cathepsin L, related |
| Oryza sativa | 4343231 | Os07g0480900 |
| Oryza sativa | 4337223 | Os04g0650000 |
| Oryza sativa | 4324982 | Os01g0907600 |
| Oryza sativa | 4337353 | Os04g0670500 |
| Oryza sativa | 4329339 | Os02g0469600 |
| Oryza sativa | 4337582 | Os05g0108600 |
| Oryza sativa | 4346292 | Os08g0556900 |
| Oryza sativa | 4337351 | Os04g0670200 |
| Oryza sativa | 4350216 | Os11g0255300 |
| Oryza sativa | 4335455 | Os04g0311400 |
| Onchocerca volvulus | OVOC3316 |
|
| Onchocerca volvulus | OVOC1748 | Cathepsin L homolog |
| Onchocerca volvulus | OVOC12825 |
|
| Onchocerca volvulus | OVOC3332 |
|
| Onchocerca volvulus | OVOC5840a |
|
| Onchocerca volvulus | OVOC5843 |
|
| Onchocerca volvulus | OVOC12274 |
|
| Onchocerca volvulus | OVOC1713a | Cathepsin L homolog |
| Onchocerca volvulus | OVOC11164a | Cathepsin F homolog |
| Onchocerca volvulus | OVOC5840b |
|
| Onchocerca volvulus | OVOC7265 |
|
| Plasmodium berghei | PBANKA_0932400 | berghepain-2 |
| Plasmodium falciparum | PF3D7_1115300 | cysteine proteinase falcipain 2b |
| Plasmodium falciparum | PF3D7_1115400 | cysteine proteinase falcipain 3 |
| Plasmodium falciparum | PF3D7_1115700 | cysteine proteinase falcipain 2a |
| Plasmodium knowlesi | PKNH_0912800 | knowpain-4 |
| Plasmodium knowlesi | PKNH_0912900 | knowpain-3 |
| Plasmodium knowlesi | PKNH_0913000 | knowpain-2 |
| Plasmodium vivax | PVX_091415 | vivapain-2 |
| Plasmodium vivax | PVX_091405 | vivapain-2 |
| Plasmodium yoelii | PY00783 | berghepain-2 |
| Schistosoma japonicum | Sjp_0107700 | ko:K01373 cathepsin F [EC3.4.22.41], putative |
| Schistosoma japonicum | Sjp_0005730 | expressed protein |
| Schistosoma japonicum | Sjp_0027020 | Cathepsin L-like proteinase precursor, putative |
| Schistosoma mansoni | Smp_034410.3 | cathepsin F (C01 family) |
| Schistosoma mansoni | Smp_034410.2 | cathepsin F (C01 family) |
| Schistosoma mansoni | Smp_034410.1 | cathepsin F (C01 family) |
| Schmidtea mediterranea | mk4.000002.39 | Cathepsin L |
| Schmidtea mediterranea | mk4.003459.01 | |
| Schmidtea mediterranea | mk4.000734.08 | Cathepsin L |
| Schmidtea mediterranea | mk4.002220.08 | Cathepsin L |
| Schmidtea mediterranea | mk4.023811.00 | Cathepsin L |
| Schmidtea mediterranea | mk4.003111.02 | |
| Schmidtea mediterranea | mk4.001447.00 | Cathepsin L |
| Schmidtea mediterranea | mk4.001924.09 | |
| Schmidtea mediterranea | mk4.001294.09 | |
| Schmidtea mediterranea | mk4.000389.00 | |
| Schmidtea mediterranea | mk4.026877.00 | Cathepsin L |
| Schmidtea mediterranea | mk4.000136.09 | Cathepsin L |
| Schmidtea mediterranea | mk4.000115.03 | |
| Schmidtea mediterranea | mk4.014091.00 | Cathepsin F |
| Schmidtea mediterranea | mk4.002298.04 | |
| Schmidtea mediterranea | mk4.017376.00 | Cathepsin L |
| Schmidtea mediterranea | mk4.001546.00 | |
| Schmidtea mediterranea | mk4.008390.00 | |
| Schmidtea mediterranea | mk4.033576.00 | Cathepsin L |
| Schmidtea mediterranea | mk4.016876.00 | Cathepsin L |
| Schmidtea mediterranea | mk4.001294.08 | Cathepsin L |
| Schmidtea mediterranea | mk4.001447.01 | |
| Schmidtea mediterranea | mk4.002220.04 | |
| Schmidtea mediterranea | mk4.019799.01 | Cathepsin F |
| Schmidtea mediterranea | mk4.020982.01 | |
| Schmidtea mediterranea | mk4.005973.01 | Cathepsin L |
| Schmidtea mediterranea | mk4.001447.09 | Cathepsin L |
| Schmidtea mediterranea | mk4.001075.04 | Cathepsin L |
| Schmidtea mediterranea | mk4.002298.05 | Cathepsin L |
| Schmidtea mediterranea | mk4.000002.11 | |
| Schmidtea mediterranea | mk4.001447.10 | Cathepsin L |
| Schmidtea mediterranea | mk4.000734.07 | |
| Schmidtea mediterranea | mk4.000136.08 | |
| Schmidtea mediterranea | mk4.040357.00 | Cathepsin L |
| Schmidtea mediterranea | mk4.001924.01 | |
| Trypanosoma brucei gambiense | Tbg972.6.725 | cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei gambiense | Tbg972.6.735 | cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei gambiense | Tbg972.6.760 | cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.1040 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.1010 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.970 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.1000 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.990 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.1060 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.1030 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.960 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.980 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.1020 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma brucei | Tb927.6.1050 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_28390 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_53250 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_18880 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_28270 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_31720 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_12120 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_17860 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_60020 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_31730 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_55820 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_37240 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_26780 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_55780 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_25670 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_44210 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_11840 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_55830 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma congolense | TcIL3000_0_49190 | cysteine peptidase, Clan CA, family C1, Cathepsin L-like |
| Trypanosoma cruzi | TcCLB.507603.260 | cysteine peptidase, putative |
| Trypanosoma cruzi | TcCLB.507603.270 | cruzipain precursor, putative |
| Trypanosoma cruzi | TcCLB.509429.320 | cysteine peptidase, putative |
| Trypanosoma cruzi | TcCLB.509401.30 | cysteine peptidase, putative |
| Trypanosoma cruzi | TcCLB.507537.20 | cysteine peptidase, putative |
| Trypanosoma cruzi | TcCLB.509401.20 | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative |
| Toxoplasma gondii | TGME49_321530 | cathepsin CPL |
| Theileria parva | TP02_0098 | cysteine protease, putative |
| Theileria parva | TP03_0283 | cysteine proteinase, putative |
| Theileria parva | TP03_0281 | cysteine proteinase, putative |
| Theileria parva | TP02_0097 | cysteine protease, putative |
| Theileria parva | TP03_0285 | cysteine proteinase |
| Theileria parva | TP02_0099 | cysteine protease, putative |
| Theileria parva | TP03_0282 | cysteine proteinase, putative |
| Trichomonas vaginalis | TVAG_151460 | Clan CA, family C1, cathepsin L or K-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_202090 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_003650 | Clan CA, family C1, papain-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_057000 | Clan CA, family C1, papain-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_164120 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_034140 | Clan CA, family C1, papain-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_427130 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_484350 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_467970 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_090100 | Clan CA, family C1, papain-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_518810 | Clan CA, family C1, papain-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_043620 | Clan CA, family C1, papain-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_325040 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_135480 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_228450 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_218830 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_096740 | Clan CA, family C1, papain-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_410260 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_465470 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_267850 | Clan CA, family C1, cathepsin L or K-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_053440 | Clan CA, family C1, papain-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_427120 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_437820 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_298080 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_405280 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_047960 | Clan CA, family C1, papain-like cysteine peptidase |
| Trichomonas vaginalis | TVAG_355480 | Clan CA, family C1, cathepsin L-like cysteine peptidase |
Essentiality
TVAG_003650 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.6.1000 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.6.1000 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.6.1000 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.6.1000 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb927.6.960 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.6.960 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.6.960 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.6.960 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_T03E6.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T03E6.7 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_T03E6.7 | Caenorhabditis elegans | slow growth | wormbase |
| TGME49_321530 | Toxoplasma gondii | Probably non-essential | sidik |
-
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
Ranking Plot