Detailed view for TVAG_374960

Basic information

TDR Targets ID: 864214
Trichomonas vaginalis, Clan SC, family S33, methylesterase-like serine peptidase
Source Database / ID: 

pI: 7.341 | Length (AA): 336 | MW (Da): 38213 | Paralog Number: 13

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12146   Serine aminopeptidase, S33

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130566)

Species Accession Gene Product
Arabidopsis thaliana AT4G14290   alpha/beta-hydrolase family protein
Arabidopsis thaliana AT4G17150   alpha/beta-Hydrolases superfamily protein
Arabidopsis thaliana AT3G23540   alpha/beta-Hydrolases superfamily protein
Cryptosporidium hominis Chro.70050   random slug cDNA-11 (Fragment)
Cryptosporidium parvum cgd7_370   protein with a conserved N-terminal region
Dictyostelium discoideum DDB_G0272791   alpha/beta hydrolase fold-1 domain-containing protein
Dictyostelium discoideum DDB_G0295699   alpha/beta hydrolase fold-1 domain-containing protein
Leishmania braziliensis LbrM.30.0470   hypothetical protein, conserved
Leishmania donovani LdBPK_300400.1   Alpha/beta hydrolase family, putative
Leishmania infantum LinJ.30.0400   hypothetical protein, conserved
Leishmania major LmjF.30.0400   hypothetical protein, conserved
Leishmania mexicana LmxM.29.0400   hypothetical protein, conserved
Neospora caninum NCLIV_035460   Alpha/beta hydrolase, related
Oryza sativa 9266683   Os02g0197900
Oryza sativa 4341501   Os06g0609700
Plasmodium berghei PBANKA_0707200   alpha/beta hydrolase, putative
Plasmodium falciparum PF3D7_0823400   alpha/beta hydrolase, putative
Plasmodium knowlesi PKNH_1317400   alpha/beta hydrolase, putative
Plasmodium vivax PVX_089195   alpha/beta hydrolase, putative
Plasmodium yoelii PY02678   hypothetical protein
Trypanosoma brucei gambiense Tbg972.6.1510   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.1810   Alpha/beta hydrolase family, putative
Trypanosoma congolense TcIL3000_6_1400   Alpha/beta hydrolase family, putative
Trypanosoma cruzi TcCLB.511491.120   Alpha/beta hydrolase family, putative
Toxoplasma gondii TGME49_271460   protein c14orf29, putative
Trichomonas vaginalis TVAG_292600   conserved hypothetical protein
Trichomonas vaginalis TVAG_316560   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_479170   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_329180   conserved hypothetical protein
Trichomonas vaginalis TVAG_112980   conserved hypothetical protein
Trichomonas vaginalis TVAG_043720   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_233340   conserved hypothetical protein
Trichomonas vaginalis TVAG_112930   conserved hypothetical protein
Trichomonas vaginalis TVAG_011790   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_460750   conserved hypothetical protein
Trichomonas vaginalis TVAG_173950   conserved hypothetical protein
Trichomonas vaginalis TVAG_374960   Clan SC, family S33, methylesterase-like serine peptidase
Trichomonas vaginalis TVAG_262420   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_369930   conserved hypothetical protein

Essentiality

TVAG_374960 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.1810 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.1810 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.1810 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.1810 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_271460 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_374960 (Trichomonas vaginalis), Clan SC, family S33, methylesterase-like serine peptidase
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