Detailed view for TVAG_121610

Basic information

TDR Targets ID: 868751
Trichomonas vaginalis, apoptosis inducing factor, putative
Source Database / ID: 

pI: 5.642 | Length (AA): 871 | MW (Da): 96072 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00753   Metallo-beta-lactamase superfamily
PF07992   Pyridine nucleotide-disulphide oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0010181   FMN binding  
GO:0005506   iron ion binding  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131036)

Species Accession Gene Product
Escherichia coli b2710   anaerobic nitric oxide reductase flavorubredoxin
Entamoeba histolytica EHI_129890   type A flavoprotein, putative
Entamoeba histolytica EHI_096710   type A flavoprotein, putative
Entamoeba histolytica EHI_159860   type A flavoprotein, putative
Entamoeba histolytica EHI_152650   type A flavoprotein, putative
Entamoeba histolytica EHI_064530   type A flavoprotein, putative
Giardia lamblia GL50803_10358   A-type flavoprotein lateral transfer candidate
Trichomonas vaginalis TVAG_121610   apoptosis inducing factor, putative
Trichomonas vaginalis TVAG_263800   disulfide oxidoreductase, putative
Trichomonas vaginalis TVAG_049830   disulfide oxidoreductase, putative
Trichomonas vaginalis TVAG_036010   A-type flavoprotein

Essentiality

TVAG_121610 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2710 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0282 0.3876 1
0.0134 0.3422 1
0.032 0.4025 1
0.0153 1 1
0.0259 0.336 0.9004
0.0138 0.8072 0.8072
0.035 0.2506 1
0.0156 1 1
0.0404 0.2792 0.8574
0.0286 1 0.5
0.024 0.347 1
0.03 0.9089 1
0.0115 1 0.5
0.0371 0.5373 1
0.0101 0.5 0.5
0.0249 0.3365 1
0.0089 0.2907 1
0.0031 0.5 0.5
0.0065 0.5 0.5
0.0088 0.4106 0.5
0.0101 0.5 0.5
0.0208 0.4509 0.7815
0.0079 0.301 0
0.0304 0.3722 1
0.0183 1 1
0.0215 0.5175 0.5175
0.0304 0.3722 1
0.03 0.9089 1
0.0224 1 1
0.0307 0.4131 1
0.0263 0.5703 1
0.0033 0.5 0.5
0.0068 0.616 0.5
0.0139 0.3313 1
0.0141 0.5 0.5
0.0051 0.5023 0.5
0.0284 0.6112 1
0.0098 0.5 0.5
0.0173 0.5058 1
0.0019 0.5 0.5
0.0151 0.5 0.5
0.0333 0.487 1
0.0161 1 1
0.0153 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_121610 (Trichomonas vaginalis), apoptosis inducing factor, putative
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