Detailed view for TVAG_073540

Basic information

TDR Targets ID: 868776
Trichomonas vaginalis, AGC family protein kinase
Source Database / ID: 

pI: 8.5767 | Length (AA): 435 | MW (Da): 50905 | Paralog Number: 44

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128437)

Species Accession Gene Product
Babesia bovis BBOV_I004190   cAMP-dependent protein kinase
Brugia malayi Bm1_26815   Protein kinase domain containing protein
Caenorhabditis elegans CELE_C54G4.1   Protein RSKN-2, isoform B
Drosophila melanogaster Dmel_CG6297   CG6297 gene product from transcript CG6297-RC
Homo sapiens ENSG00000162302   ribosomal protein S6 kinase, 90kDa, polypeptide 4
Homo sapiens ENSG00000100784   ribosomal protein S6 kinase, 90kDa, polypeptide 5
Loa Loa (eye worm) LOAG_04180   AGC/RSK/MSK protein kinase
Mus musculus ENSMUSG00000024952   ribosomal protein S6 kinase, polypeptide 4
Mus musculus ENSMUSG00000021180   ribosomal protein S6 kinase, polypeptide 5
Schmidtea mediterranea mk4.000422.13  
Schmidtea mediterranea mk4.000110.10  
Schmidtea mediterranea mk4.006314.00  
Trichomonas vaginalis TVAG_092840   AGC family protein kinase
Trichomonas vaginalis TVAG_204500   3-phosphoinositide dependent protein kinase-1, putative
Trichomonas vaginalis TVAG_134480   ribosomal protein S6 kinase, 90kD, polypeptide, putative
Trichomonas vaginalis TVAG_224630   AGC family protein kinase
Trichomonas vaginalis TVAG_210130   AGC family protein kinase
Trichomonas vaginalis TVAG_378240   AGC family protein kinase
Trichomonas vaginalis TVAG_485840   AGC family protein kinase
Trichomonas vaginalis TVAG_038960   AGC family protein kinase
Trichomonas vaginalis TVAG_086220   AGC family protein kinase
Trichomonas vaginalis TVAG_011660   cAMP-dependent protein kinase catalytic subunit, putative
Trichomonas vaginalis TVAG_089630   AGC family protein kinase
Trichomonas vaginalis TVAG_131900   AGC family protein kinase
Trichomonas vaginalis TVAG_369880   AGC family protein kinase
Trichomonas vaginalis TVAG_420830   AGC family protein kinase
Trichomonas vaginalis TVAG_276510   AGC family protein kinase
Trichomonas vaginalis TVAG_483480   AGC family protein kinase
Trichomonas vaginalis TVAG_134450   serine/threonine-protein kinase ypk, putative
Trichomonas vaginalis TVAG_192000   AGC family protein kinase
Trichomonas vaginalis TVAG_413170   AGC family protein kinase
Trichomonas vaginalis TVAG_245290   AGC family protein kinase
Trichomonas vaginalis TVAG_260080   AGC family protein kinase
Trichomonas vaginalis TVAG_404590   AGC family protein kinase
Trichomonas vaginalis TVAG_121760   AGC family protein kinase
Trichomonas vaginalis TVAG_430020   AGC family protein kinase
Trichomonas vaginalis TVAG_295020   AGC family protein kinase
Trichomonas vaginalis TVAG_306350   AGC family protein kinase
Trichomonas vaginalis TVAG_325790   AGC family protein kinase
Trichomonas vaginalis TVAG_244150   serine/threonine-protein kinase sgk, putative
Trichomonas vaginalis TVAG_359220   AGC family protein kinase
Trichomonas vaginalis TVAG_269900   AGC family protein kinase
Trichomonas vaginalis TVAG_073540   AGC family protein kinase
Trichomonas vaginalis TVAG_025670   AGC family protein kinase
Trichomonas vaginalis TVAG_384870   AGC family protein kinase
Trichomonas vaginalis TVAG_352330   AGC family protein kinase
Trichomonas vaginalis TVAG_286510   AGC family protein kinase
Trichomonas vaginalis TVAG_125670   AGC family protein kinase
Trichomonas vaginalis TVAG_475960   AGC family protein kinase
Trichomonas vaginalis TVAG_183840   AGC family protein kinase
Trichomonas vaginalis TVAG_075790   serine/threonine-protein kinase, putative
Trichomonas vaginalis TVAG_188800   AGC family protein kinase
Trichomonas vaginalis TVAG_139000   AGC family protein kinase
Trichomonas vaginalis TVAG_463710   AGC family protein kinase
Trichomonas vaginalis TVAG_061270   AGC family protein kinase
Trichomonas vaginalis TVAG_381330   AGC family protein kinase
Trichomonas vaginalis TVAG_257220   AGC family protein kinase

Essentiality

TVAG_073540 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C54G4.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C54G4.1 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 4 Compounds References
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 5 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 26.1% 264 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 37.2% 290 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 38.0% 284 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 24.3% 304 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 27.4% 299 aa Compounds References
Patiria pectinifera Cdc2 300 aa 22.1% 308 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 25.3% 190 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 29.7% 340 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 23.7% 283 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 37.3% 284 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0026 0.5 0.5
0.0023 0.3144 0.3144
0.0039 0.9485 0.5
0.0061 0.6883 0.5304
0.0025 0.3144 0.3144
0.0007 0.5 0.5
0.0098 0.3242 0.2373
0.0016 0.5 0.5
0.0041 0.308 0.3144
0.0011 1 0.5
0.0008 0.5 0.5
0.011 0.3045 0.3045
0.0062 0.6935 0.5
0.0025 0.3144 0.3144
0.0012 0.5 0.5
0.0022 0.3144 0.3144
0.0081 1 0.5
0.0007 0.5 0.5
0.004 0.3144 0.3144
0.0039 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0023 0.5 0.5
0.0088 0.4477 1
0.0059 1 1
0.0063 0.7244 0
0.0063 1 1
0.002 0.3144 0.3144
0.0018 0.5 0.5
0.0027 1 0.5
0.0036 0.5 0.5
0.0033 1 1
0.0059 1 1
0.0067 0.5 0.5
0.0091 1 0.5
0.0081 0.5 0.5
0.0037 1 0.5
0.0069 0.3067 0.5
0.0066 0.3101 0.5
0.0041 0.308 0.3144
0.0064 0.3377 0.5
0.0016 0.5 0.5
0.0032 0.5 0.5
0.0092 1 0.5
0.0042 0.5 0.5
0.0032 0.5 0.5
0.0029 0.5 0.5
0.0041 0.5502 0.538
0.0059 1 1
0.0033 0.5 0.5
0.0041 0.3144 0.3144
0.0025 0.2552 0
0.0039 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0056 1 0.5
0.0093 0.8828 0.5
0.0022 0.5 0.5
0.0012 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TVAG_073540 (Trichomonas vaginalis), AGC family protein kinase
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