Detailed view for TVAG_375610

Basic information

TDR Targets ID: 869310
Trichomonas vaginalis, TKL family protein kinase
Source Database / ID: 

pI: 6.7721 | Length (AA): 788 | MW (Da): 90043 | Paralog Number: 32

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132604)

Species Accession Gene Product
Caenorhabditis elegans CELE_R05H5.4   Protein R05H5.4
Trichomonas vaginalis TVAG_433970   TKL family protein kinase
Trichomonas vaginalis TVAG_497150   TKL family protein kinase
Trichomonas vaginalis TVAG_401630   TKL family protein kinase
Trichomonas vaginalis TVAG_044540   TKL family protein kinase
Trichomonas vaginalis TVAG_129420   TKL family protein kinase
Trichomonas vaginalis TVAG_209030   TKL family protein kinase
Trichomonas vaginalis TVAG_351950   TKL family protein kinase
Trichomonas vaginalis TVAG_035690   TKL family protein kinase
Trichomonas vaginalis TVAG_212280   TKL family protein kinase
Trichomonas vaginalis TVAG_139540   TKL family protein kinase
Trichomonas vaginalis TVAG_360800   TKL family protein kinase
Trichomonas vaginalis TVAG_397930   TKL family protein kinase
Trichomonas vaginalis TVAG_020870   TKL family protein kinase
Trichomonas vaginalis TVAG_129100   TKL family protein kinase
Trichomonas vaginalis TVAG_164190   TKL family protein kinase
Trichomonas vaginalis TVAG_461860   TKL family protein kinase
Trichomonas vaginalis TVAG_406320   protein kinase atn1, putative
Trichomonas vaginalis TVAG_372230   TKL family protein kinase
Trichomonas vaginalis TVAG_372050   TKL family protein kinase
Trichomonas vaginalis TVAG_046910   TKL family protein kinase
Trichomonas vaginalis TVAG_429470   TKL family protein kinase
Trichomonas vaginalis TVAG_315000   TKL family protein kinase
Trichomonas vaginalis TVAG_333060   TKL family protein kinase
Trichomonas vaginalis TVAG_200580   protein tyrosine kinase, putative
Trichomonas vaginalis TVAG_375610   TKL family protein kinase
Trichomonas vaginalis TVAG_197930   TKL family protein kinase
Trichomonas vaginalis TVAG_181840   TKL family protein kinase
Trichomonas vaginalis TVAG_478740   TKL family protein kinase
Trichomonas vaginalis TVAG_495130   receptor-interacting serine-threonine kinase, putative
Trichomonas vaginalis TVAG_402090   TKL family protein kinase
Trichomonas vaginalis TVAG_495120   conserved hypothetical protein
Trichomonas vaginalis TVAG_411390   TKL family protein kinase
Trichomonas vaginalis TVAG_113700   TKL family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 21.7% 263 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 32.3% 201 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0012 0.5 0.5
0.0098 0.3242 0.2373
0.0063 1 1
0.0056 1 0.5
0.0088 0.4477 1
0.0016 0.5 0.5
0.0023 0.5 0.5
0.0011 1 0.5
0.0062 0.6935 0.5
0.0093 0.8828 0.5
0.0029 0.5 0.5
0.0037 1 0.5
0.0018 0.5 0.5
0.0059 1 1
0.0032 0.5 0.5
0.0016 0.5 0.5
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0059 1 1
0.0064 0.3377 0.5
0.0007 0.5 0.5
0.0033 0.5 0.5
0.0026 0.5 0.5
0.0091 1 0.5
0.0012 0.5 0.5
0.0027 1 0.5
0.0069 0.3067 0.5
0.0032 0.5 0.5
0.0061 0.6883 0.5304
0.0039 0.5 0.5
0.0063 0.7244 0
0.0092 1 0.5
0.0007 0.5 0.5
0.0003 0.5 0.5
0.0039 0.9485 0.5
0.0033 1 1
0.0081 1 0.5
0.0066 0.3101 0.5
0.0004 0.5 0.5
0.0059 1 1
0.0081 0.5 0.5
0.0067 0.5 0.5
0.0039 0.5 0.5
0.0042 0.5 0.5
0.0022 0.5 0.5
0.0036 0.5 0.5
0.0008 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_375610 (Trichomonas vaginalis), TKL family protein kinase
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