Detailed view for TVAG_044490

Basic information

TDR Targets ID: 869932
Trichomonas vaginalis, Rabx18 protein, putative
Source Database / ID: 

pI: 5.9074 | Length (AA): 201 | MW (Da): 22180 | Paralog Number: 13

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0003924   GTPase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_142302)

Species Accession Gene Product
Trichomonas vaginalis TVAG_384490   Rab9, putative
Trichomonas vaginalis TVAG_042990   RAB-33, putative
Trichomonas vaginalis TVAG_581400   GTP binding protein rare7l, putative
Trichomonas vaginalis TVAG_044490   Rabx18 protein, putative
Trichomonas vaginalis TVAG_442250   Rab9, putative
Trichomonas vaginalis TVAG_280870   Rab7, putative
Trichomonas vaginalis TVAG_474030   Rab15, 13, 10, 1, 35, 5, and, putative
Trichomonas vaginalis TVAG_404940   RAB, putative
Trichomonas vaginalis TVAG_122340   RAB, putative
Trichomonas vaginalis TVAG_037110   rho3, putative
Trichomonas vaginalis TVAG_031480   Rab21, putative
Trichomonas vaginalis TVAG_065320   Rab21, putative
Trichomonas vaginalis TVAG_151010   Rabx19 protein, putative
Trichomonas vaginalis TVAG_048600   small GTPase rabi, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_044490 (Trichomonas vaginalis), Rabx18 protein, putative
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