Detailed view for TVAG_258120

Basic information

TDR Targets ID: 870967
Trichomonas vaginalis, secreted glucosidase, putative
Source Database / ID: 

pI: 5.0678 | Length (AA): 422 | MW (Da): 48827 | Paralog Number: 11

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00722   Glycosyl hydrolases family 16

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130926)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0280263   glycoside hydrolase family 16 protein
Mycobacterium tuberculosis Rv0315   Possible beta-1,3-glucanase precursor
Mycobacterium ulcerans MUL_4744   beta-1,3-glucanase
Trichomonas vaginalis TVAG_359050   conserved hypothetical protein
Trichomonas vaginalis TVAG_375690   conserved hypothetical protein
Trichomonas vaginalis TVAG_375680   conserved hypothetical protein
Trichomonas vaginalis TVAG_258120   secreted glucosidase, putative
Trichomonas vaginalis TVAG_375670   conserved hypothetical protein
Trichomonas vaginalis TVAG_243940   conserved hypothetical protein
Trichomonas vaginalis TVAG_243950   secreted glucosidase, putative
Trichomonas vaginalis TVAG_382890   conserved hypothetical protein
Trichomonas vaginalis TVAG_248280   gram-negative bacteria binding protein, putative
Trichomonas vaginalis TVAG_162850   secreted glucosidase, putative
Trichomonas vaginalis TVAG_382900   conserved hypothetical protein
Trichomonas vaginalis TVAG_359060   secreted glucosidase, putative

Essentiality

TVAG_258120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu318 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_258120 (Trichomonas vaginalis), secreted glucosidase, putative
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