Detailed view for TVAG_196230

Basic information

TDR Targets ID: 872573
Trichomonas vaginalis, malate dehydrogenase, putative
Source Database / ID: 

pI: 7.77 | Length (AA): 170 | MW (Da): 18237 | Paralog Number: 8296

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00056   lactate/malate dehydrogenase, NAD binding domain
PF02866   lactate/malate dehydrogenase, alpha/beta C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016616   oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  
GO:0016615   malate dehydrogenase activity  
GO:0016491   oxidoreductase activity  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  
GO:0006108   malate metabolic process  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

PDB tag
  • 4UUO:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0354 0.4277 0.6575
0.0292 0.4665 0.5428
0.0308 0.3815 0.9142
0.0494 0.2937 0.7751
0.0292 0.4665 0.5428
0.0333 0.2684 0.8703
0.0197 0.2835 0.8686
0.0704 0.3205 0.7069
0.0232 0.3813 1
0.0072 0.2592 1
0.0524 0.3316 0.6847
0.0246 0.3856 1
0.0374 0.2657 0.707
0.0263 0.2633 0.8911
0.0374 0.2657 0.707
0.0052 0.2847 1
0.0307 0.3846 1
0.054 0.5274 0.6722
0.077 0.5776 0.7218
0.016 0.2968 0.766
0.0674446 0.356728 0.790148
0.0248 0.275 0.8413
0.0731 0.3709 0.6248
0.0199 0.2882 0.87
0.0845 0.5545 0.6672
0.0109 0.3162 1
0.0215 0.2525 1
0.0347 0.4945 0.5275
0.0379 0.5742 0.6704
0.0465 0.6128 0.6912
0.0268 0.2727 0.8511
0.0238 0.277 0.8335
0.0368 0.2656 0.8834
0.0043 0.2775 1
0.0407 0.4254 0.1474
0.0295 0.4129 0.158
0.016 0.3341 1
0.0125 0.2988 0.3696
0.0467 0.297 0.7655
0.1071 0.527 0.6058
0.0196 0.3083 0.8054
0.0196 0.3083 0.8054
0.0707 0.4651 0.7078
0.0086 0.3948 0.5982
0.0223 0.3042 1
0.0199 0.2882 0.87
0.0592 0.5723 0.5611
0.0134 0.3565 1
0.0703 0.4656 0.7067
0.0311 0.3815 0.9142
0.0199 0.2882 0.87
0.099 0.5497 0.7486
0.0109 0.3633 1
0.0221 0.4684 0.1107
0.0177 0.4156 1
0.0231 0.2805 0.9034
0.0233 0.2773 0.8322
0.0845 0.5545 0.6672
0.019 0.2816 1
0.0494 0.2937 0.7751
0.0125 0.259 0.7937
0.0134 0.3565 1
0.0461 0.4274 0.5693
0.0272 0.3802 0.9026
0.0274 0.2728 0.8506
0.0680367 0.313044 0.728005
0.0477 0.3884 0.8316
0.0348 0.4758 0.1043
0.1452 0.3757 0.6189
0.0234 0.3314 1
0.007 0.3074 0.7018
0.0329 0.3818 0.9192
0.0232 0.3813 1
0.0661 0.3778 0.4492
0.0196 0.2947 1
0.016 0.3265 1
0.0592 0.5723 0.5611
0.0672 0.3077 0.7364
0.0342 0.3717 0.6238
0.014 0.2529 1
0.1147 0.3567 0.6438
0.1242 0.373 0.6223
0.045 0.3225 0.7027
0.0264 0.279 0.8982
0.0629 0.314 0.7212
0.0252 0.265 0.8265
0.099 0.5497 0.7486
0.0194 0.4516 0.5527
0.0785 0.3098 0.7314
0.0569 0.5379 0.749
0.0674446 0.356728 0.790148
0.0497 0.3133 0.723
0.0525 0.6362 0.6875
0.0316 0.3553 1
0.0477 0.3884 0.8316
0.0199 0.2882 0.87
0.0105 0.3654 1
0.0661 0.3778 0.4492
0.0279 0.2963 0.4343
0.0231 0.2805 0.9034
0.0326 0.394 0.9232
0.0636 0.2957 0.7692
0.0379 0.5742 0.6704
0.0189 0.3717 1
0.055 0.3513 0.6517
0.0857 0.3458 0.6602
0.0109 0.3162 1
0.0221 0.4684 0.1107
0.0359 0.2653 0.8848
0.0251 0.2947 1
0.0237 0.2577 0.8878
0.0361 0.2652 0.8855
0.1001 0.351 0.6522
0.0232 0.3813 1
0.054 0.5274 0.6722
0.0583 0.3406 0.6688

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_196230 (Trichomonas vaginalis), malate dehydrogenase, putative
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