Detailed view for TVAG_107010

Basic information

TDR Targets ID: 873502
Trichomonas vaginalis, sensor histidine kinase, putative
Source Database / ID: 

pI: 6.0223 | Length (AA): 1382 | MW (Da): 160304 | Paralog Number: 8

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00072   Response regulator receiver domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0000160   two-component signal transduction system (phosphorelay)  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129304)

Species Accession Gene Product
Arabidopsis thaliana AT2G01830   histidine kinase 4
Arabidopsis thaliana AT5G35750   histidine kinase 2
Arabidopsis thaliana AT1G27320   histidine kinase 3
Candida albicans CaO19.12648   histidine kinase osmosensor
Candida albicans CaO19_5181   hypothetical protein
Candida albicans CaO19.5181   histidine kinase osmosensor
Dictyostelium discoideum DDB_G0277883   HisK family protein kinase
Escherichia coli b2786   hybrid sensory histidine kinase, in two-component regulatory system with UvrY
Oryza sativa 9271913   Os01g0923700
Oryza sativa 4348447   Os10g0362300
Schmidtea mediterranea mk4.071585.00  
Schmidtea mediterranea mk4.029167.00  
Trichomonas vaginalis TVAG_147200   sensory transduction histidine kinase bacterial, putative
Trichomonas vaginalis TVAG_107010   sensor histidine kinase, putative
Trichomonas vaginalis TVAG_000590   two component sensor and regulator histidine kinase bacteria, putative
Trichomonas vaginalis TVAG_213160   sensory transduction histidine kinase, putative
Trichomonas vaginalis TVAG_053990   receptor histidine kinase, putative
Trichomonas vaginalis TVAG_304230   sensor histidine kinase, putative
Trichomonas vaginalis TVAG_239940   receptor histidine kinase, putative
Trichomonas vaginalis TVAG_005560   sensory transduction histidine kinase bacterial, putative
Trichomonas vaginalis TVAG_013040   conserved hypothetical protein

Essentiality

TVAG_107010 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2786 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Arabidopsis thaliana histidine kinase 3 Compounds References
Arabidopsis thaliana histidine kinase 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0064 0.7187 0.2272
0.0456 0.292 0.7669
0.0589 0.4405 0.6074
0.0328 0.304 0.7669
0.0108 0.3556 0.3309
0.0328 0.304 0.7669
0.0165 0.7187 0.2272
0.0129 0.7187 0.2272
0.0129 0.7187 0.2272
0.044 0.7382 0.2272
0.0064 0.7187 0.2272
0.0336 0.346 0.2272
0.0328 0.304 0.7669
0.0502 0.7603 0.2272
0.0581 0.7669 0.7669
0.0381 0.4427 0.7669
0.044 0.7382 0.2272
0.0263 0.7187 0.2272
0.0109 0.4371 0.7454
0.0494 0.7382 0.2272

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_107010 (Trichomonas vaginalis), sensor histidine kinase, putative
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