pI: 7.1619 |
Length (AA): 346 |
MW (Da): 38628 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129576)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G23070 | Thymidine kinase |
Arabidopsis thaliana | AT3G07800 | thymidine kinase |
Caenorhabditis elegans | CELE_Y43C5A.5 | Protein THK-1, isoform B |
Dictyostelium discoideum | DDB_G0289179 | calmodulin-binding protein |
Entamoeba histolytica | EHI_177540 | thymidine kinase, putative |
Giardia lamblia | GL50803_8364 | Thymidine kinase |
Homo sapiens | ENSG00000167900 | thymidine kinase 1, soluble |
Leishmania braziliensis | LbrM.21.1410 | thymidine kinase, putative |
Leishmania donovani | LdBPK_211450.1 | thymidine kinase, putative |
Leishmania infantum | LinJ.21.1450 | thymidine kinase, putative |
Leishmania major | LmjF.21.1210 | thymidine kinase, putative |
Leishmania mexicana | LmxM.21.1210 | thymidine kinase, putative |
Mus musculus | ENSMUSG00000025574 | thymidine kinase 1 |
Oryza sativa | 4331376 | Os03g0113100 |
Trypanosoma brucei gambiense | Tbg972.10.960 | thymidine kinase, putative |
Trypanosoma brucei | Tb927.10.880 | thymidine kinase |
Trypanosoma congolense | TcIL3000_0_05400 | thymidine kinase, putative |
Trypanosoma congolense | TcIL3000_0_01250 | thymidine kinase, putative |
Trypanosoma congolense | TcIL3000_10_740 | thymidine kinase, putative |
Trypanosoma cruzi | TcCLB.506855.260 | thymidine kinase, putative |
Trypanosoma cruzi | TcCLB.511133.20 | thymidine kinase, putative |
Trichomonas vaginalis | TVAG_050740 | thymidine kinase, putative |
Trichomonas vaginalis | TVAG_083490 | thymidine kinase, putative |
Trichomonas vaginalis | TVAG_344830 | thymidine kinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.880 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.880 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.880 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.880 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y43C5A.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | thymidine kinase 1, soluble | Compounds | References |
Ureaplasma parvum serovar 3 (strain ATCC 700970) | Thymidine kinase | Compounds | References |
Cricetulus griseus | Thymidine kinase, cytosolic | Compounds | References |
Rattus norvegicus | Thymidine kinase | Compounds | References |