pI: 4.5073 |
Length (AA): 271 |
MW (Da): 30144 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_131966)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G29330 | tropinone reductase |
Arabidopsis thaliana | AT1G07450 | NAD(P)-binding Rossmann-fold superfamily protein |
Arabidopsis thaliana | AT2G29310 | tropinone reductase-like protein |
Arabidopsis thaliana | AT2G29300 | tropinone reductase-like protein |
Arabidopsis thaliana | AT1G07440 | NAD(P)-binding Rossmann-fold superfamily protein |
Arabidopsis thaliana | AT2G30670 | NAD(P)-binding Rossmann-fold superfamily protein |
Arabidopsis thaliana | AT2G29340 | tropinone reductase-like protein |
Arabidopsis thaliana | AT2G29320 | tropinone reductase-like protein |
Candida albicans | CaO19.10415 | similar to Sou1p but not required for sorbose utilization |
Candida albicans | CaO19.2897 | similar to SOU1 but not required for sorbose utilization |
Candida albicans | CaO19.2896 | sorbose utilization/short-chain alcohol dehydrogenase |
Candida albicans | CaO19.10414 | sorbose utilization/short-chain alcohol dehydrogenase |
Mycobacterium tuberculosis | Rv1928c | Probable short-chain type dehydrogenase/reductase |
Trichomonas vaginalis | TVAG_308120 | short-chain dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1959 | Mycobacterium tuberculosis | non-essential | nmpdr |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Cochliobolus lunatus | 17-beta-hydroxysteroid-dehydrogenase | 270 aa | 20.1% | 264 aa | Compounds | References |