Detailed view for TVAG_296300

Basic information

TDR Targets ID: 877572
Trichomonas vaginalis, purine nucleoside phosphorylase, putative
Source Database / ID: 

pI: 5.1504 | Length (AA): 240 | MW (Da): 26495 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01048   Phosphorylase superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0008930   methylthioadenosine nucleosidase activity  
GO:0008782   adenosylhomocysteine nucleosidase activity  
GO:0003824   catalytic activity  
GO:0019509   methionine salvage  
GO:0009164   nucleoside catabolic process  
GO:0009116   nucleoside metabolic process  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130719)

Species Accession Gene Product
Arabidopsis thaliana AT4G34840   5'-methylthioadenosine nucleosidase 2
Arabidopsis thaliana AT4G38800   methylthioadenosine nucleosidase 1
Escherichia coli b0159   5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Entamoeba histolytica EHI_000720   MTA/SAH nucleosidase, putative
Giardia lamblia GL50803_4059   5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase
Mycobacterium tuberculosis Rv0091   Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase
Mycobacterium ulcerans MUL_4862   bifunctional Mta/Sah nucleosidase Mtn
Oryza sativa 4339898   Os06g0112200
Oryza sativa 4325883   Os01g0229800
Treponema pallidum TP0170   pfs protein (pfs)
Trichomonas vaginalis TVAG_296300   purine nucleoside phosphorylase, putative

Essentiality

TVAG_296300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu92 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Compounds References
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Compounds References
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.3437 1 1
0.1782 0.7726 1
0.4794 1 1
0.6394 1 1
0.0755 0.2681 0.2631
0.0405 0.8702 1
0.2222 1 1
0.2019 0.7779 0.5
0.0405 1 1
0.1774 1 0.5
0.5445 1 1
0.1453 0.2923 0.2923
0.2222 1 1
0.5955 1 1
0.3754 1 1
0.2344 0.923 1
0.3838 0.2995 1
0.1884 1 0.5
0.0328 0.7989 1
0.0405 0.5 0.5
0.6061 1 1
0.6061 1 1
0.1492 0.2666 0
0.0662 0.4026 1
0.1508 0.2655 0.2655
0.0716 1 1
0.1357 0.2878 0.2875
0.0901 0.3068 0.3068
0.1768 0.2963 0.2959
0.0328 0.8187 1
0.7992 1 1
0.0721 0.4193 1
0.1515 1 0.5
0.1526 0.273 0.273
0.1696 0.2827 0
0.1248 1 1
0.1314 0.2921 0.2686
0.1732 0.2917 0.284
0.2213 0.9352 1
0.5445 1 1
0.0405 0.2689 1
0.2225 0.9312 1
0.3511 1 1
0.0755 0.2681 0.2631
0.0756 0.2653 0.5
0.7274 1 1
0.0405 1 1
0.086 0.8264 1
0.2381 0.2606 1
0.0994 0.5599 1
0.0346 0.8187 1
0.2484 1 1
0.4794 1 1
0.1676 1 1
0.2087 1 1
0.0402 0.497 1
0.2205 1 1
0.1746 0.2673 0.2673
0.1453 0.2923 0.2923
0.5219 0.9393 1
0.1453 0.2923 0.2923
0.1318 0.6779 1
0.1802 1 0.5
0.0652 1 1
0.1503 0.2939 0.2939
0.5445 1 1
0.3385 1 0.5
0.0624 0.293 0
0.0402 0.497 1
0.2194 1 1
0.2381 0.2606 1
0.2258 0.978 1
0.3754 1 1
0.0405 0.8187 1
0.0405 0.3204 0.8151
0.0405 0.2689 1
0.0405 0.5 0.5
0.5836 1 1
0.1836 0.8194 1
0.5083 1 1
0.0721 0.4193 1
0.1985 0.6391 1
0.764 1 1
0.3074 1 0.5
0.1503 0.2939 0.2939
0.0691 0.5 0.5
0.3754 1 1
0.2175 0.6346 1
0.5955 1 1
0.0405 0.4698 0.5
0.1453 0.2923 0.2923
0.0405 0.5 0.5
0.0405 0.5 0.5
0.2165 0.9387 1
0.1314 0.2921 0.2686
0.1125 0.2944 0.294
0.6061 1 1
0.1473 0.2771 0.272
0.0324 1 0.5
0.1105 0.2977 0
0.1985 0.6391 1
0.1495 0.3047 0.3035
0.0405 0.2518 1
0.0336 0.8189 1
0.0895 0.7687 1
0.8043 1 1
0.2208 1 0.5
0.2354 0.9211 1
0.0437 0.5273 0.8472
0.2429 1 1
0.0755 0.2681 0.2631
0.1965 0.7429 1
0.2205 1 1
0.5219 0.9393 1
0.2193 0.9342 1
0.1906 1 1
0.1078 1 1
0.0901 0.3068 0.3068
0.1248 1 1
0.3838 0.2995 1
0.0994 0.5599 1
0.2381 0.2606 1
0.1979 0.9959 1
0.2492 1 1
0.135 0.5 0.5
0.6899 1 1
0.4007 1 0.5
0.5219 0.9393 1
0.5955 1 1
0.2484 1 1
0.1175 0.2901 0.2877
0.1605 1 1
0.764 1 1
0.0437 0.5273 0.8472
0.1485 0.2987 0.2924
0.1456 0.8414 1
0.6815 1 1
0.0405 0.2964 0.6169
0.6061 1 1
0.3746 1 0.5
0.1952 1 1
0.1715 0.2964 0.296
0.068 1 1
0.2168 0.9162 1
0.0257 0.2951 1
0.0352 0.8187 1
0.3838 0.2995 1
0.0405 0.5 0.5
0.6858 1 1
0.4542 1 1
0.341 1 1
0.3838 0.2995 1
0.0405 0.5136 1
0.5705 1 1
0.5088 1 1
0.2168 0.9162 1
0.0565 0.3955 1
0.0961 0.2813 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_296300 (Trichomonas vaginalis), purine nucleoside phosphorylase, putative
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