pI: 11.8123 |
Length (AA): 155 |
MW (Da): 17531 |
Paralog Number:
7
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126668)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G77750 | small ribosomal subunit protein S13 |
Arabidopsis thaliana | AT4G09800 | 40S ribosomal protein S18 |
Arabidopsis thaliana | AT1G34030 | 40S ribosomal protein S18 |
Arabidopsis thaliana | AT1G22780 | 40S ribosomal protein S18 |
Babesia bovis | BBOV_IV005450 | 40S ribosomal protein S18, putative |
Brugia malayi | Bm1_46915 | 40S ribosomal protein S18 |
Candida albicans | CaO19.13764 | potential mitochondrial ribosomal protein similar to S. cerevisiae SWS2 (YNL081C) putative mitochondrial small subunit protein ( |
Candida albicans | CaO19.7018 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS18A (YDR450W) small subunit protein S18A |
Candida albicans | CaO19.6406 | potential mitochondrial ribosomal protein similar to S. cerevisiae SWS2 (YNL081C) putative mitochondrial small subunit protein ( |
Candida albicans | CaO19_7018 | hypothetical protein |
Caenorhabditis elegans | CELE_Y57G11C.16 | Protein RPS-18 |
Cryptosporidium hominis | Chro.30283 | ribosomal protein S18 |
Cryptosporidium parvum | cgd3_2440 | ribosomal protein S18A, rps18ap, HhH domain |
Chlamydia trachomatis | CT_509 | 30S ribosomal protein S13 |
Dictyostelium discoideum | DDB_G0276415 | 40S ribosomal protein S18 |
Drosophila melanogaster | Dmel_CG8900 | Ribosomal protein S18 |
Escherichia coli | b3298 | 30S ribosomal subunit protein S13 |
Echinococcus granulosus | EgrG_000980000 | 40S ribosomal protein S18 |
Entamoeba histolytica | EHI_031400 | ribosomal protein S18, putative |
Entamoeba histolytica | EHI_086120 | ribosomal protein S18, putative |
Entamoeba histolytica | EHI_009680 | ribosomal protein S18, putative |
Entamoeba histolytica | EHI_086140 | Ras guanine nucleotide exchange factor, putative |
Echinococcus multilocularis | EmuJ_000980000 | 40S ribosomal protein S18 |
Giardia lamblia | GL50803_15551 | Ribosomal protein S18 |
Homo sapiens | ENSG00000231500 | ribosomal protein S18 |
Leishmania braziliensis | LbrM.35.1050 | 40S ribosomal protein S18, putative |
Leishmania braziliensis | LbrM.35.1060 | 40S ribosomal protein S18, putative |
Leishmania donovani | LdBPK_360990.1 | 40S ribosomal protein S18, putative |
Leishmania infantum | LinJ.36.1000 | 40S ribosomal protein S18, putative |
Leishmania infantum | LinJ.36.0990 | 40S ribosomal protein S18, putative |
Leishmania major | LmjF.36.0940 | 40S ribosomal protein S18, putative |
Leishmania major | LmjF.36.0930 | 40S ribosomal protein S18, putative |
Leishmania mexicana | LmxM.36.0930 | 40S ribosomal protein S18, putative |
Leishmania mexicana | LmxM.36.0940 | 40S ribosomal protein S18, putative |
Loa Loa (eye worm) | LOAG_07945 | 40S ribosomal protein S18 |
Mycobacterium leprae | ML1960c | PROBABLE 30S RIBOSOMAL PROTEIN S13 RPSM |
Mus musculus | ENSMUSG00000008668 | ribosomal protein S18 |
Mus musculus | 623505 | predicted gene 6436 |
Mycobacterium tuberculosis | Rv3460c | 30S ribosomal protein S13 RpsM |
Mycobacterium ulcerans | MUL_0845 | 30S ribosomal protein S13 |
Neospora caninum | NCLIV_047630 | 40S ribosomal protein S18, putative |
Oryza sativa | 4333848 | Os03g0704000 |
Oryza sativa | 6450193 | ribosomal protein S13 |
Oryza sativa | 4342526 | Os07g0173700 |
Oryza sativa | 4334407 | Os03g0794700 |
Plasmodium berghei | PBANKA_0922100 | 40S ribosomal protein S18, putative |
Plasmodium falciparum | PF3D7_1126200 | 40S ribosomal protein S18, putative |
Plasmodium knowlesi | PKNH_0924100 | 40S ribosomal protein S18, putative |
Plasmodium vivax | PVX_091925 | 40S ribosomal protein S18, putative |
Plasmodium yoelii | PY07508 | ribosomal protein S13/S18 |
Saccharomyces cerevisiae | YDR450W | ribosomal 40S subunit protein S18A |
Saccharomyces cerevisiae | YML026C | ribosomal 40S subunit protein S18B |
Saccharomyces cerevisiae | YNL081C | putative mitochondrial 37S ribosomal protein SWS2 |
Schistosoma japonicum | Sjp_0058880 | ko:K02964 small subunit ribosomal protein S18e, putative |
Schistosoma mansoni | Smp_074780 | 40S ribosomal protein S18 |
Schmidtea mediterranea | mk4.002789.00 | 40S ribosomal protein S18 |
Schmidtea mediterranea | mk4.005019.05 | 40S ribosomal protein S18 |
Schmidtea mediterranea | mk4.001291.03 | 40S ribosomal protein S18 |
Trypanosoma brucei gambiense | Tbg972.10.6520 | 40S ribosomal protein S18, putative |
Trypanosoma brucei gambiense | Tbg972.10.6510 | 40S ribosomal protein S18, putative |
Trypanosoma brucei | Tb927.10.5330 | 40S ribosomal protein S18, putative |
Trypanosoma brucei | Tb11.v5.1060 | 40S ribosomal protein S18, putative |
Trypanosoma brucei | Tb927.10.5340 | 40S ribosomal protein S18, putative |
Trypanosoma congolense | TcIL3000_10_4490 | 40S ribosomal protein S18, putative |
Trypanosoma congolense | TcIL3000_10_4480 | 40S ribosomal protein S18, putative |
Trypanosoma cruzi | TcCLB.506679.100 | 40S ribosomal protein S18, putative |
Trypanosoma cruzi | TcCLB.506679.94 | 40S ribosomal protein S18, putative |
Toxoplasma gondii | TGME49_225080 | ribosomal protein RPS18 |
Treponema pallidum | TP0210 | 30S ribosomal protein S13 |
Theileria parva | TP01_0351 | 40S ribosomal protein S18, putative |
Trichomonas vaginalis | TVAG_020480 | 40S ribosomal protein S18, putative |
Trichomonas vaginalis | TVAG_065040 | 30S/40S ribosomal protein, putative |
Trichomonas vaginalis | TVAG_341090 | 30S ribosomal protein S13p, putative |
Trichomonas vaginalis | TVAG_184530 | 30S ribosomal protein S13, putative |
Trichomonas vaginalis | TVAG_043810 | 30S/40S ribosomal protein, putative |
Trichomonas vaginalis | TVAG_487930 | 40S ribosomal protein S18, putative |
Trichomonas vaginalis | TVAG_419040 | 30S/40S ribosomal protein, putative |
Trichomonas vaginalis | TVAG_487360 | 30S ribosomal protein S13p, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0320 | 30S ribosomal protein S13 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.5330 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.5330 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.5330 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.5330 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3298 | Escherichia coli | essential | goodall |
CELE_Y57G11C.16 | Caenorhabditis elegans | sterile | wormbase |
TGME49_225080 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.