pI: 8.1187 |
Length (AA): 412 |
MW (Da): 46799 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_174469)
Species | Accession | Gene Product |
---|---|---|
Trichomonas vaginalis | TVAG_369920 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_339280 | CAMK family protein kinase |
Trichomonas vaginalis | TVAG_125520 | CAMK family protein kinase |
Trichomonas vaginalis | TVAG_163610 | CAMK family protein kinase |
Trichomonas vaginalis | TVAG_464230 | CAMK family protein kinase |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 29.6% | 277 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 27.3% | 267 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 29.9% | 167 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 25.9% | 193 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 25.7% | 307 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 27.8% | 288 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 28.0% | 293 aa | Compounds | References |